Alessandro Prigione
@AlePrigio
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Stem Cell Metabolism lab. Using iPSCs to search for cures for rare mitochondrial diseases. Editor-in-Chief of Stem Cell Research. @[email protected]
Düsseldorf, Germany
Joined December 2016
RT @the_ISoOR: The Impact of Mutant #Huntingtin on Neurodevelopment Unveiled through Human #Brain #Organoid Models. #BrainOrganoid.By Pawel….
nature.com
Nature Communications - Using brain organoids models, Prigione and colleagues uncovered the impact of Huntington’s disease on human brain developmental and identified early dysregulation of...
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RT @JIMD_Editors: Next up in the modelling IEM session, Dr @AlePrigio discusses developing brain organoid models for the study of #mitodis….
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Beautiful run this morning for the Kastelo charity run. Thanks to the SSIEM2024 organizers! @ssiem2024_Porto
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RT @MDC_Berlin: Researchers at @MDC_Berlin and @HHU_de have identified a gene that affects mitochondria in an #organoid model of #Huntingto….
mdc-berlin.de
Researchers in Berlin and Düsseldorf have implicated a new gene in the progression of Huntington’s disease in a brain organoid model. The gene may contribute to brain abnormalities much earlier than...
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This was quite a long project starting several years ago and a huge collaborative efforts! Mainly with @HHU_de and @MDC_Berlin but also other labs in Germany, Greece and Spain! .Great collaboration with co-last author @metzgerlab. And thanks to funding from @dfg_public.
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It's out! Excited to share our latest work in Nat Comms. We found that mutant Huntingtin impairs human neurodevelopment in brain organoid models through early disregulation of the mitochondrial protein CHCHD2. Thanks to all coauthors!.
nature.com
Nature Communications - Using brain organoids models, Prigione and colleagues uncovered the impact of Huntington’s disease on human brain developmental and identified early dysregulation of...
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Great collaboration with Antonio del Sol, @OlePless, Christine Rose, @eperlste and many others. Grateful to the support from @BMBF_Bund and @EJPRareDiseases, European Commission, @cure_mito, @UMDF, PALS, and Mito Help!.
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Delighted to share our latest preprint! We used iPSC-derived brain organoids and deep learning screenings to identify new drugs to treat the mitochondrial disease Leigh syndrome. Graduate student Carmen Menacho received a Merit Award for this #ISSCR2024.
biorxiv.org
Mitochondrial disease encompasses untreatable conditions affecting tissues with high energy demands. A severe manifestation of mitochondrial disease is Leigh syndrome (Leigh), which causes defects in...
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RT @ElenaRugarli: How do axons maintain functional #mitochondria? Happy to share our last #CLUH story. #ScienceAdvancesResearch
https://t.c….
science.org
CLUH regulates mitochondrial function in peripheral motor axons, thus promoting growth and preventing degeneration.
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RT @jobRxiv: Postdoc positions in pancreas development & stem cells in the Spagnoli Lab @LabSpagnoli. Come join us as a #postdoc to lead a….
jobrxiv.org
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
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Wonderful opportunity! A great lab in a new exciting institute in a great city. Apply!.
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RT @AWartiovaara: Very happy to share our new article of the interaction of mitochondria, innate immunity and viral infections and the rele….
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RT @TrendsNeuro: 'Balancing neuronal activity to fight neurodevelopmental disorders'. 'Spotlight' commentary by Stephanie Le, Carmen Menach….
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Delighted to share our spotlight article @TrendsNeuro to comment on a beautiful work by the Guemez-Gamboa lab on modeling a rare neurodevelopment disorder with brain organoids.
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First half marathon done! Great time (for me) and no rain!
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Must-read review article.
Nature review article: A break in mitochondrial endosymbiosis as a basis for inflammatory diseases
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RT @Mito_Redox: Why Drug Developers Have a Growing Interest in Targeting Mitochondria . Listen and learn. .
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RT @FIT_NGIn: 🧠The synapse density rapidly increases post-birth👶, reaches its maximum during infancy, at which stage it is double the amoun….
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