Bree Aldridge
@AldridgeLab
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Our lab develops quantitative methods to design therapies for tuberculosis and to understand complex cell behaviors.
Tufts University, Boston, MA
Joined November 2013
Together this project really underscores the importance of studying fundamentals of cell biology in non-model organisms. This was a really challenging project made possible by an incredible collaboration with Eun Seon Chung, @Ariel_4321, and @KarPrathitha. 5/5 #tuberculosis.
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Finally, it is thought that a broad range of cell types grow exponentially at the single-cell level, but we find that Mtb grow linearly, implying that we need to study what processes Mtb use to control growth as it is fundamentally different from other studied cell types. 4/5.
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Second, we found the dominant polar growth pattern is *not* growth first from the old pole as it is in M. smegmatis - instead, we see that many cells start elongating from the new pole soon after division. 3/5.
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First, we found that growth behaviors of Mtb are quite variable, but also that they do not follow the same deterministic growth heterogeneity patterns as M. smegmatis - we now have a new open question about how Mtb create and maintain this variation. 2/5.
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Tap tap…is the🎙️ still on? This work has been in the works for a long time! We studied the growth behaviors and cell cycle timing of individual TB bacilli and ended up with a series of surprises and a lot of new questions. 1/5
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RT @BayAreaLyme: .@trevercsmith of @TuftsMedSchool has been named winner of the #BAL 2024 Emerging Leader Award. Dr. Smith will receive $15….
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This is an amazing program! Please RT! Would be happy to discuss opportunities in my group or at Tufts for IRACDA fellows!.
WE ARE HIRING! Currently recruiting for our next cycle beginning 9/1/24 for postdoctoral scholar training positions! Applications due 2/1/24! #sciencejobs #postdoc #science #research #career #hiring #jobs @TuftsUniversity @TuftsGSBS @TuftsMedSchool
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RT @MTChinMDPhD: Happy to celebrate the inauguration of new Tufts President Sunil Kumar and share the platform with TUSM Dean @hboucher3 GS….
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Had a great celebratory week welcoming Tufts' 14th president, Sunil Kumar! #TuftsLightingTheWay
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As more types of bacteria are used for fundamental studies of cell biology, I think we will discover that there is far more diversity in the interworking of cells than previously believed 5/5.
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@KarPrathitha @Ariel_432 We have yet to understand why or how Mtb grow linearly and how they systematically create so much heterogeneity, but it is clear that to understand the single-cell characteristics of Mtb, we have to continue to study the pathogen itself 4/5.
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@KarPrathitha @Ariel_432 Most cell types have an exponential growth mode at single-cell level, but we discovered that Mtb growth is linear. We find that Mtb’s (slow) growth has a unique linear growth mode that is overlayed on more cell-to-cell variation than in model organisms 3/5.
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@KarPrathitha @Ariel_432 We report the characteristics of Mtb growth & cell cycle timing for the first time. We find a LOT of variation in growth speed, cell size, and cell cycle timing. But unlike in M. smegmatis, there is not a deterministic relationship between growth pole age & growth behaviors 2/5.
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Excited to share our new preprint describing the single-cell growth behaviors of pathogenic Mycobacterium #tuberculosis with Eun Seon Chung @KarPrathitha @Ariel_432 and Maliwan Kamkaew 1/5.
Mycobacterium tuberculosis grows linearly at the single-cell level with larger variability than model organisms #biorxiv_micrbio.
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We took the afternoon off for a goat hike and ice cream! It was a blast 🐐🍁🍃🍦. I am very thankful to work with this incredible team of creative and kind people!
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@CarolynBertozzi @siegristpalmore @jcslab @MireilleKamariz Oh and also. your hometown is SO EXCITED too! <3 We will take a walk by LHS in your honor today :) @CarolynBertozzi.
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Congratulations to @CarolynBertozzi! Thanks for making tools to help us understand #tuberculosis and also for training amazing colleagues :) @siegristpalmore @jcslab @MireilleKamariz.
Carolyn Bertozzi – awarded the 2022 #NobelPrize in Chemistry – has taken click chemistry to a new dimension and started utilising it in living organisms. Her bioorthogonal reactions take place without disrupting the normal chemistry of the cell.
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Thrilled (and flattered) to read this preview by one of my scientific heroes and leader in the field of drug #combinationtherapy @ac_palmer @SarahCooperUNC.
Online now: Predicting in vivo activity of combination therapies from in vitro drug pairs in diverse environments
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