Alan Yu🇭🇰
@AlanYuNeph
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Nephrologist, physician-scientist. Director, Division of Nephrology, Jared Grantham Kidney Institute, University of Kansas @KUNeph Opinions are my own
Kansas City, KS
Joined February 2009
Next up SGLT2i in ADPKD PKD was an exclusion criteria in all of the big RCTs FDA specifically tells people not to use these drugs KDIGO follows the FDA guidelines except in heart failure but "studies are needed" #KidneyWk
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Thank you 😄 @ASNKidney @ASNpublications for hosting a wonderful luncheon — a great opportunity for connection, collaboration, and smiles! @KristaLentine @sydney_tang @AnnaGaddy @gudnephron @javo_neyra
#ASN #KidneyWK
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Don't miss! Join us for the 2025 Best of ASN Journals session at #KidneyWk. Join us on Thursday, November 6 at 2:00 PM in Grand Ballroom A of the George R. Brown Convention Center for a lively discussion and check out the article collection below. https://t.co/akNDNcRXhs
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It has been 2 years since Rajnish Mehrotra stepped up to become the inaugural senior editor-in-chief of the ASN Publications portfolio. Read the interview with #ASNKidneyNews here to learn more about the portfolio structure and what's next here: https://t.co/tpJTh2KqVs
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Congratulations @Reem_A_Mustafa @KUJGKI @KUNeph 👏🎉 Thrilled to see your leadership accomplishments recognized at the national level !
ASN Kidney News Oct/Nov 2025 Distinguished Leader Award: Reem A. Mustafa, MD, PhD, MPH, FASN https://t.co/nRAwECrnuY
@asnpublications @ASNKidney
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Top Reviewer of 2025 for #ASNKidney360 @valerie_luyckx shares: "reviewing for Kidney360, especially the Global Perspectives, is a wonderful opportunity to learn from experts on the ground - everywhere -who may not get the chance to publish so visibly elsewhere" Thank you,
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Delighted that our paper on KLF6 and RNA polymerase II subunit RPB1 is published in this month’s issue in JASN! @SKMallipattu @SamaDimartino @nehabengujarati @RBronshteyn @sbudeptofmed @SBNephrology
The October issue of JASN is now available online! Topics covered this month include: - Peer Mentoring and Hospitalizations in Hemodialysis - AKI Risk Classification- and more Check out the issue here: https://t.co/c5T9NXidxS
#ASNJASN Cover by Chung et al.
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🚨 Kidney + AI milestone 🚨 Never been more excited to share!!! We built Nephrobase Cell+, the first multispecies, multimodal kidney foundation model: Trained on ~40M cells Across 4 species (human, mouse, rat, pig) From 5 modalities (scRNA, snRNA, snATAC, CosMx, Xenium) Kidney
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Same IVC, one doctor says ‘small and collapsible,’ another calls it ‘plethoric.’ Don’t fall for the cylinder effect‼️- fan your probe side-to-side to find the true maximum diameter, and confirm in transverse. #POCUS #FOAMed #Nephpearls
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Development of a cyst-targeted therapy for polycystic kidney disease using an antagonistic dimeric IgA monoclonal antibody against cMET. --> Our new paper was just published. https://t.co/R7QzxgohAz
cell.com
Current PKD therapies are limited by poor efficacy and off-target toxicity. Schimmel et al. show that recombinant dimeric IgAs can reach kidney cyst lumens and engage molecular targets to slow...
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Honored to host @IgAN_JBarratt for a special grand rounds @KUNeph @KUJGKI 4 approved treatments for IgAN and many more lined up over the next year. What an exciting time in nephrology!
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Our latest, now in print in @jclinicalinvest (w/ cover! 🎉) Led by @caryboyd3, we identified a functional role for #WNK bodies in K+ homeostasis, highlighting a #condensate 🫧 that can influence kidney physiology & nephron sexual dimorphism, w/ implications for human health 1/
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I am very proud to share the publication of our group by German Magaña-Ávila @GermanRick95 commanded by María Castañeda-Bueno @MARIACASTABU, showing the role of NRBP1 and TSC22D in WNK body formation and WNK4-NCC activation. Kudos María! https://t.co/p9bKiuRiqv
science.org
The pseudokinase NRBP1 and its associated TSC22D proteins modulate WNK kinases to regulate sodium reabsorption in the kidney.
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Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive development of kidney cysts. This Review discusses ADPKD diagnosed in adulthood. https://t.co/rM63LRoPoD
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Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.
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Thank you @asnpublications for this opportunity to highlight these differences between CKD associated cognitive impairment vs other common causes of dementia.
#Perspective discusses paradoxical elevation of cerebral blood flow and cognitive impairment in patients with CKD. https://t.co/H15MjMhYnr
#ASNJASN
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I sure hope the endless discussions of “which magical salt water solution is best for hospitalized patients” ends…
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We have an open #ERC funded PhD position to work on #cilia #mitochondria #PKD and #matabolism Deadline July 7th. Look forward to welcoming a talented PhD student to our lab in beautiful Milan 👇
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Nephrology people...this is no time to stay silent. "...some of the biggest changes will be felt at the NIH, where the budget document lists 2026 funding at $27.5 billion, down from nearly $48.5 billion in 2025." https://t.co/vlADGbWHbA
amp.cnn.com
A budget proposal for the US Department of Health and Human Services details extensive cuts to funding for the National Institutes of Health, part of an effort to consolidate the work of its 27...
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