
Alan H Bryce
@AlanBryce9
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Medical oncologist and cancer researcher specializing in Prostate Cancer. Chief Clinical Officer, City of Hope Arizona, Professor of Molecular Medicine,Tgen
Phoenix, AZ
Joined July 2019
Clinically meaningful Imaging upgrade by #AlinaKüper: CAIX PET/CT detected 98% of regions vs 40% by CT; changed management in 7 pts; uptake time x up to 1.0. High SUV hints at 177Lu-CAIX theranostics. #ESMO25 #RCC @myESMO @Annals_Oncology @OncLive @OncoAlert
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Breaking news from #ESMO25 in Berlin 👉Randomized trial of Pluvicto/Lu-177 vs. docetaxel (DOC) in 199 pts with mCRPC #prostatecancer 👉progressing after ARPI therapy👉Similar PFS (primarily endpoint) but higher OS with docetaxel👇#KimChi #ESMO25 @OncoAlert @urotoday @PCF_Science
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Our very own @MayoCancerCare Dr. Jacob Orme presents data on plasma exchange to remove soluble PD-L1 followed by ICI in patients with ICI-refractory melanoma. ORR 61%, often durable. #ESMO25
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I love this blog post from my patient Haley Crider. She has become a tireless supporter of other cancer patients through her involvement in our local AYA program. It’s always helpful for me to read about the patient’s perspective on their journey.
haveasenseoftumor.com
Every October as the weather starts to turn from disgustingly hot and miserable to “oh wait it’s not actually so bad outside,” I find myself a little on edge and semi-anxious. It really sneaks up on...
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TGen and City of Hope Cancer Center Phoenix had the privilege to partner with Matriarch Mixer last week for their September Indigenous Wellness Summit. Speakers shared about the importance of: ☝️ Prioritizing your health, 🧬 Understanding your family history and genetic makeup &
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Great work from our lead long cancer med onc at City of Hop Arizona.
1/14 #WCLC25 Thrilled to be presenting a poster 📍(P1.11.71) “Preliminary Safety and Efficacy of Restorative Microbiota Therapy (RMT) with Chemoimmunotherapy in Metastatic NSCLC” on 📅September 7, ⏰10:30 AM to 12 PM. Brief #tweetorial here:
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Congrats to @IrbazRiaz et al. on this excellent review of AI across the cancer care continuum, clear, timely, and very well written. A must-read for oncology and digital health. @JournalCancer @RamalingamMD @OncoAlert @MayoClinic @VUMChealth
https://t.co/YBoda9YT4C
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Who's the best candidate for Lutetium therapy? PSMA PET result matters, but 👉CT/DNA, NGS, and histology also do. Excellent talks by #MikeMorris & @sartor_oliver at #2025USPCCC Highlighting data by Eugene Kwon & @AzadOncology in @NatureMedicine👇@urotoday @PCFnews @OncoAlert
Just started👉2025 United States #ProstateCancer Consensus Conference (USPCCC) 👉with @AlanBryce9 ‘s introductory remarks. @philkuo @cityofhope debating for PSMA PET for treatment selection. Caveat👉 Medical conditions with false positive PSMA PET lesions 👇@urotoday @PCFnews
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Just started👉2025 United States #ProstateCancer Consensus Conference (USPCCC) 👉with @AlanBryce9 ‘s introductory remarks. @philkuo @cityofhope debating for PSMA PET for treatment selection. Caveat👉 Medical conditions with false positive PSMA PET lesions 👇@urotoday @PCFnews
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A new model for mCRPC that adds ctDNA-based genomic alterations to clinical data improves overall survival prediction by ~30%. AR, PTEN, TP53, MYC among key drivers. A step closer to precision trials. #ProstateCancer #Oncology
@mishabeltran @EAntonarakis @MattGalsky
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BMS-986365: a first-in-class dual AR degrader + antagonist -Potent vs wildtype & mutant AR -Superior to enzalutamide in preclinical models -PSA ↘️ in post-ARPI mCRPC patients @CCR_AACR @OncoAlert @APCCC_Lugano @OncBrothers #prostatecancer
https://t.co/ruHkS9eJAi
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I'm pleased to launch a new series, "Science Matters." We’ll explore why science matters, and which scientific 'matters' are key to translating cancer breakthroughs into better care for patients everywhere. I hope you enjoy the first installment!
connection.asco.org
2025-2026 ASCO president Dr. Eric Small introduces “Science Matters,” a series of interviews and videos which will discuss how scientific discovery drives real-world change.
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Great data from @Ecastromarcos. It makes the point that pathogenic BRCA mutations are both predictive and prognostic in metastatic prostate cancer.
Our last paper in @Annals_Oncology: BRCA and HRR muts have similar prevalence in low and high volume mHSPC, but greater impact in low volume😯. Doublets with ARPi or docetaxel result in comparable poor outcomes for BRCA pts https://t.co/NJ5i6VEhEg
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@DrYukselUrun @ASCO @OncoAlert @neerajaiims @CParkMD @TheLancet @APCCC_Lugano @Larvol @AzadOncology @yekeduz_emre @montypal @shilpaonc @VivekSubbiah @DrAndreFay @SoaresAndrey @Silke_Gillessen @dmukherji @SuyogCancer I worry that the majority of that benefit is being driven by BRCA and PLAB2. Is this going to be your 1L for all HRRm? @neerajaiims @DrRanaMcKay @dr_yakupergun PARPi have a good amount of side effects with very little benefit with certain HRR deficiencies. Love this slide by
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Thank you for sharing your story and being such a relentless patient advocate @CEgglesfield, and that you for your support of @cityofhope in Arizona. And thank you to @people for covering the story.
Facing cancer for the third time taught me everything about resiliency. Grateful to share my story with @people! Full article: https://t.co/7urepIlWYD #cancersurvivor, #prostatecancerawareness, #menshealthmatters
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Thanks to @montypal for hosting. And thanks to @Waltstadler5 for his no nonsense insights. I've been learning from him for many years. It's a pleasure to push the cutting edge of cancer care with colleagues like this.
Some patients are cured. Others live decades with managed cancer. On this episode of On the Edge of Breakthrough: Voices of Cancer Research with host @montypal, @WalterStadler5 explains how both are victories—and both are breakthroughs. Tune in now: https://t.co/jKZ0DZad0E
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A novel west-African germline founder mutation in HOXB13 (p.X285Kext) increases risk of high-grade prostate cancer but also enhances sensitivity to hormonal therapy. Congrats to PCF-funded Mayuko Kanayama 👏 @neerajaiims @PCFnews @urotoday @EdEsplin
https://t.co/j2EzocJlys
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Pasritamig, a First-in-Class, Bispecific T-Cell Engager Targeting Human Kallikrein 2, in Metastatic Castration-Resistant Prostate Cancer: A Phase 1 Study out on JCO https://t.co/ziHQywB99i In this Phase 1 trial, pasritamig—a novel bispecific antibody targeting KLK2 on
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