Akash Mishra Profile
Akash Mishra

@Akash_Mishra7

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236
Following
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112

MD/PhD Student @ZuckerSOM • NIMH NRSA F30 • @HofstraU ‘19 • Optimizing & expanding DBS indications using human iEEG and neural oscillations

New York, USA
Joined March 2022
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@MIT_Picower
MIT Picower Institute
10 days
New from @MillerLabMIT: To get back on track after a distraction, the brain appears to employ a rotating traveling wave, a new study by MIT neuroscientists finds. https://t.co/dwNPhEiwpn @ScienceMIT @mitbrainandcog #neuroscience #cognition
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picower.mit.edu
To get back on track after a distraction, the cortex appears to employ a rotating traveling wave, a new study by MIT neuroscientists finds.
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@dgolubMD
Danielle Golub, MD, MSCI
30 days
Great start to #2025CNS in LA😎 with the @CNSResidents Committee Meeting! So great to catch up with old friends, show some @NorthwellNsurg pride, and make new connections! Looking forward to a fantastic conference! @AlonKashanian @CNS_Update @NSTumorSection #Neurosurgery 🧠🔥
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@biorxiv_neursci
bioRxiv Neuroscience
2 months
Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations. https://t.co/IRXHavv8m3 #biorxiv_neursci
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@ASSFNeurosurg
ASSFN
3 months
📢Calling ASSFN Members and Stereotactic and Functional Neurosurgery Resident/Fellows Don’t miss the next ASSFN Town Hall! 🗓️Wednesday, 9/24 | ⏰ 7 PM CT Register now: https://t.co/CxLNU4c5FO #Neurosurgery #FunctionalNeurosurgery #NeuroInnovation #NeuroSurgeryCommunity
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@Englot
Dario J. Englot
3 months
Are you a neurosurgery resident or medical student interested in Functional Neurosurgery, but seeking more research or clinical mentorship than what's at your own institution? Learn more about the new #ASSFN AMPLify Mentorship Program. This is our second year in the program, and
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@Akash_Mishra7
Akash Mishra
3 months
We’re incredibly proud to share this work with you: https://t.co/eeLSyyJx62 A BIG thank you to my research mentors @Steph_Bickel and Ash Mehta, to the @NIMHgov for supporting my work, to @ZuckerSoM @NorthwellHealth @NorthwellNsurg, and to you for reading along! (fin)
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science.org
HFOs are bursts of brain activity that coordinate the processing and memory integration of the continuous world around us.
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@Akash_Mishra7
Akash Mishra
3 months
In summary, these findings suggest that HFOs across the hippocampal-cortical memory network represent a powerful coordinating mechanism. They may guide how our brains segment, encode, and retrieve rich, continuous episodic memories from our everyday lives (10/n)
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@Akash_Mishra7
Akash Mishra
3 months
The strength of motif reactivation during replay and retrieval was related with whether participants later remembered the event. We also found that these unique motifs lingered for three subsequent replay periods. Hence, HFOs may help us bind new memories to older ones! (9/n)
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@Akash_Mishra7
Akash Mishra
3 months
Co-HFO motifs showed specificity for events and re-occurred not only in the immediate post-boundary “replay period” but also during later recall. This links co-HFOs with the reinstatement of memories during consolidation and retrieval. (8/n)
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@Akash_Mishra7
Akash Mishra
3 months
We then identified “co-HFO motifs,” or event-specific spatiotemporal patterns of co-HFOs that occurred during initial event viewing. We looked to see if these motifs re-emerged at event boundaries (replay) and during free recall (retrieval). (7/n)
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@Akash_Mishra7
Akash Mishra
3 months
Further, co-HFO locations changed based on the “granularity” of the segmentation. Major event boundaries were more associated with co-HFOs in higher-order association cortices while simpler boundaries (e.g. camera angle changes) largely activated lower-order visual regions. (6/n)
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@Akash_Mishra7
Akash Mishra
3 months
We also looked beyond the hippocampus and found that coincident HFOs (co-HFOs) across the hippocampal-cortical network also increase after event boundaries. Interestingly, these events predominate in cortical regions that have been previously shown to underlie event segmentation.
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@Akash_Mishra7
Akash Mishra
3 months
Our human intracranial recordings allowed us to localize these HFO increases to the right-anterior hippocampus and the CA1 subfield. This specificity supports models where the anterior hippocampus integrates information across longer timescales. (4/n)
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@Akash_Mishra7
Akash Mishra
3 months
HFOs are a highly-synchronizing phenomenon, and we found that HFOs increase in activity ~2sec after the brain detects an “event boundary,” or timepoints where one “chunk” of an experience ends and another begins. This is a critical window for memory consolidation, or “replay.”
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@Akash_Mishra7
Akash Mishra
3 months
When we go about our days, we experience a continuous stream of information. But when we recall it later, we tend to find that we’ve “chunked” this experience into individual, meaningful episodes. This process is called event segmentation. (2/n)
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@Akash_Mishra7
Akash Mishra
3 months
How does the human brain process the continuous world around us and transform it into distinct memories? Our latest research, recently published in @ScienceAdvances, uncovers how brain waves called high frequency oscillations (HFOs) may support this amazing feat! (1/n)
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@DrDanSchneider
Dan Schneider
4 months
Our new study in The Spine Journal raises some important questions about robotic spine surgery implementation: 🔴 58-minute average delays during complications 🔴 1 in 3 cases abandoned the robot mid-surgery
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