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If you have “longevity genes”, it seems what you do lifestyle wise matters very little . If you don’t have “longevity genes”, lifestyle plays a larger role but rarer to end up 100+ . Right now, you can look at family tree and genetic tests but hard to really know

RT @AbudBakri: Undoing some of the blue light damage incurred . R/IR from the sun rise/set

This is concerning . We need circadian therapeutics… or do they already exist?.

RT @caloriesproper2: How you gonna treat a mood disorder with something that causes circadian arrhythmia?. Celexa suppresses melatonin. If….

RT @bitcoinand_beef: This progression is directly correlated with the increase of chronic disease. (Light pollution map over time). A larg….

A lot of issues attributed to genetics are a common exposure with similar genetic risk.

If your grandfather smokes and got lung cancer 🫁.And your father smokes and got lung cancer 🫁.And you smoke…. Is this a genetic or lifestyle disease?.

RT @AbudBakri: What no one is discussing:. Male skin is fundamentally different than female skin when it comes to solar exposure. In male s….

RT @zaidkdahhaj: The real ones know when that circulatory, pineal melatonin starts to hit through darkness and minimal circadian lighting a….

Undoing some of the blue light damage incurred . R/IR from the sun rise/set

Young men and women seem to have same rate of wound healing. Older men slow down, thought to be under the influence of DHT/T. There are some potential mechanisms to investigate here.

1. Post the intervention.2. Post the before after labs.

What no one is discussing:. Male skin is fundamentally different than female skin when it comes to solar exposure. In male skin testosterone is 5AR’d into DHT under the high solar redox from UV light. Men have far more testosterone available for this. What implications does this

What the hell is DHT optimization anyways?. How are you changing the redox that leads to increased 5AR?.

I have yet to see someone do “DHT optimization” and show that their levels have increased. Lifestyle, supplement or otherwise . Someone prove me wrong

RT @AbudBakri: the dichotomy of TRT (or T supplementation) . Excellent intervention when you’re aged and/or hypogonadal (over 40). Terrible….

the dichotomy of TRT (or T supplementation) . Excellent intervention when you’re aged and/or hypogonadal (over 40). Terrible idea when you’re young. Speed runs aging and thymic involution. Life is better with more T but antagonistic pleiotropy. There will be a right age for each.

Spoiler 1: it does not. Spoiler 2: a vial of testosterone is cheaper and 100x more effective (you don’t need it, but if you’re insisting on exogenous support…) . Spoiler 3: most people taking this supp aren’t nearly training hard enough, eating enough protein, or.

RT @NTFabiano: We underestimate the importance of circadian biology in the timing of treatment for mental health.

RT @AbudBakri: For years the “evidence based” people clowned collagen intake. “You’re just eating expensive amino acids”. People reported a….