Flow sorting of Perivascular Mesenchymal Progenitor Cells from human Adipose Tissue Pericyte CD146+CD34−CD31−CD45− Adventitial progenitor CD34+CD146−CD31−CD45− What are those CD34+CD146+CD31−CD45− cells?😁 @NThottappillil @AaronWJames_Lab #MethodsMolBiol 2024

Thrilled to share our new PNAS study defining neuron–sarcoma signaling as a driver of bone tumor progression, revealed through computational and in vivo models. Grateful to all co-authors and collaborators! Thank you @PNASNews for featuring our work on the cover! #CancerResearch

Study in @PNASNews ( https://t.co/1S0Yc63K3s) by @HopkinsMedicine @JHUPath shows in mice that 2 @US_FDA-OK'd pain drugs also inhibit nerve signaling/blood vessels in #Osteosarcomas & slow growth & spread. Info: https://t.co/W7VGJSbAXV. @sowmya_rames @Qin_Qizhi @AaronWJames_Lab

Nephron progenitor fate is modulated by angiotensin type 1 receptor signaling in human kidney organoids https://t.co/NKA21KQr2S

Highlight from BoneResearch! 📢Don’t miss 【Top 5 articles in the first half of 2025】Macrophages play a key role in intervertebral disc degeneration. This review provides insights into their regulatory mechanisms and potential therapeutic strategies, potentially reducing pain

Cytokeratin 19-CreERT Rosa26-mTomato lineage-tracing mice were used to assess endocrine conversion of CK19+ cells during islet regeneration induced by mesenchymal stem cell conditioned media. Read the results: https://t.co/QWemDsyhtr

Schwann cells in peripheral nerves help bone healing by transforming into MSCs, which aid bone growth and blood vessel repair. This process is driven by Shh signaling. This discovery could enhance bone regeneration in aging or disease.🥳 #nerves #cell #bone @BoneRes_Office

We are inviting applications for a full-time, tenure-track SURGICAL PATHOLOGIST faculty position at the Johns Hopkins Hospital. The ideal candidate would have an area of expertise, with priority given to breast pathology @TheISBP If interested, apply at

John Hopkins Pathology has an unexpected opening for our 2026-2027 advanced surgical pathology fellowship, which offers trainees the opportunity to independently sign out cases in a highly supported setting. See https://t.co/omgWnNt3t6 for more details.

Genetic ablation of p16 mitigates premature osteoporosis induced by PTHrP nuclear localization sequence and C-terminal deletion through inhibition of cellular senescence https://t.co/yoUm0xLLD6

New faces and also some departures @ the James lab. Welcome to postdoc Chunbao Rao and belated welcome to Luizhi Hao. Master's students Maryam Beg and Myles Zhou are graduating and off to bigger things!

🚨 New paper alert from the @AaronWJames_Lab! 🦴 Fascinating work uncovering neuron-to-bone crosstalk under high fat diet conditions. Published in @BoneRes_Office A big step forward in understanding how metabolic state shapes skeletal health. Check it out! 📈👏 #BoneBiology

Based on a mouse model, @Masnsen_Cherief @AaronWJames_Lab explore how a high-fat diet causes nerve damage and weaker bones, suggesting diabetes disrupts nerve-to-bone signals and affecting bone health in type 2 diabetes!👇 #bone #diet #diabetes @BoneRes_Office

Sharing a new study @AaronWJames_Lab! We report—for the first time—that diabetic neuropathy affects the bone periosteum, ~70% sensory nerve loss. This disrupts bone structure, but restoring nerve signals helps! https://t.co/MzozIWcNSM @JHUPath @NIH @MerkinPnnrCtr @JournBoneres

@AaronWJames_Lab Excited to present our work on how sensory neurons regulate osteosarcoma progression at FACTOR 2025 in Salt Lake City @GrandAmerica Grateful to be part of this inspiring community #MIBAgents #osteosarcoma #SaltLakeCity

If they can handcuff a U.S. Senator for asking a question, imagine what they will do to you.

Spatial transcriptomics is transforming musculoskeletal research by mapping gene expression in tissue context, offering insights into development and disease!🧐 #gene #tissue #bone @BoneRes_Office https://t.co/MkSnHAH86s

IGF2BP3 protein's role in promoting rheumatoid arthritis is revealed in a new study, suggesting it could be a target for future treatments.🧐 #protein #bone @BoneRes_Office https://t.co/3oZIOgydpZ

Without its international students, Harvard is not Harvard.

Fixing cell energy centers through the SIRT3–PINK1–PKM2 pathway helps protect joints and improve movement in osteoarthritis by removing damaged parts and helping cells produce energy!🧐 #cell #osteoarthritis #bone @BoneRes_Office https://t.co/XniftRWbzm