Angelique C Paulk
@ACPaulk
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I am a researcher working on the neural mechanisms of behavior at Massachusetts General Hospital.
Joined September 2013
Incredible effort from a massive team led by Charlie Windolf and Erdem Varol to develop DREDge motion correction algorithm of high resolution neural data across species including humans is finally out in Nature Methods! It was an honor to be involved!
nature.com
Nature Methods - DREDge is a software tool for motion correction of high-density electrophysiology recordings. It can handle action potential or local field potential data and is demonstrated on a...
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Our language neuroscience lab ( https://t.co/2uchBfwFQd) is looking for a new lab manager/FT RA to start in the summer. Apply here: https://t.co/FRJqOYaA03 We'll start reviewing apps in early Mar. (Unfortunately, MIT does not sponsor visas for these positions, but OPT works.)
evlab.mit.edu
Our research aims to understand how the language system works and how it fits into the broader landscape of the human mind and brain.
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Really enjoying the incredible talks at the MIT Neurotech 2024. Even more excited that the first two talks had shout outs to natural world utilized and inspired technologies from the ocean among incredible molecular and imaging advances. Neuroethology! https://t.co/9k2bgEeloV
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I got to talk about using human brain cell models from https://t.co/XtdS9niQ60 to illustrate brain activity recorded with Neuropixels, thin film, and other microelectrodes. @NeuroMorphoOrg & researchers have provided incredible community resources!
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Peter came up with a great title! This article came together in 2 days, but it really was an accumulation of literature and years of observations of the brain in response to direct electrical stimulation, where we ask if it is moving toward a prescriptive therapy. @MGH_CNTR
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New perspective piece/review from @PeterNHadar, @ZelmannRina, @PariyaSalami, myself, and Syd Cash entitled "The Neurostimulationist will see you now: prescribing direct electrical stimulation therapies for the human brain in epilepsy and beyond":
frontiersin.org
As the pace of research in implantable neurotechnology increases, it is important to take a step back and see if the promise lives up to our intentions. Whil...
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* notably after many attempts!!! There's too many people to thank, but I especially thank Sydney Cash lab at MGH, the Shadi Dayeh lab @UCSDJacobs , Drs. Gavin Dunn, Daniel Cahill, Ziv Williams, Isabel Arrillaga-Romany, and @MGHNeurology @MGHNeurosurg @MGH_CNTR @MGHNeuroSci !!!!
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Since 2016: I wrote 26 grants (22 as PI) 2019: 2 paradigm-shifting papers ( https://t.co/WilIehYskB & https://t.co/PAxMvhH2ER) Since 2020: Inspired, propose using high resolution microelectrodes to study Cancer Neuroscience in vivo. 2024: Notice of Award for my first R01*!!
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New TBS findings w/ iEEG by brilliant @YuhaoHuangMD! TBS → plasticity in minutes; DLPFC stim affects ACC; Connectivity predicts response! 🧠⚡️Opens new avenues for TBS optimization. More w/ TMS-iEEG, 3x TBS & units soon! Thanks @ACPaulk & team for collaborating 🙏 @StanfordBrain
Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with @DrCoreyKeller @ACPaulk, now out in @NatureComms, finding that TBS can produce plasticity-like changes in just minutes of stim. https://t.co/hDCFvqwsxJ
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Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with @DrCoreyKeller @ACPaulk, now out in @NatureComms, finding that TBS can produce plasticity-like changes in just minutes of stim. https://t.co/hDCFvqwsxJ
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Human brain responses to Theta burst stimulation can modulate with each stim! Incredible work from @YuhaoHuangMD, Cash lab, @KellerStanfordU , @DrCoreyKeller , and with help from our amazing patient participants! @MGH_CNTR @MGHNeurosurg @MGHNeurology @MGHNeuroSci Full thread:
Theta-burst stim (TBS) is used to treat depression, but how does it work? I dug into this question in my research yr with @DrCoreyKeller @ACPaulk, now out in @NatureComms, finding that TBS can produce plasticity-like changes in just minutes of stim. https://t.co/hDCFvqwsxJ
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Very proud of this one!!!! @Anth_Allam @SameerShethMD @abp4_ankit @NeuroPolarbear @BCMFromtheLabs @bcm_ocd @ Twitterless Sandy
A new study published in @NatureMedicine, Drs. @SameerShethMD, Wayne Goodman, @NicoleProvenza, A. Allam, S. Reddy & others @bcmhouston @TexasChildrens discovers a new biomarker for obsessive-compulsive disorder, transforming #OCD diagnosis & treatment: https://t.co/yHWSt9QyRm
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Excited to have our paper on semantic encoding during language comprehension out in Nature this week! https://t.co/T7TognRP6h
nature.com
Nature - By tracking the activity of individual neurons using microarrays and Neuropixels probes, a study examines the representation of linguistic meaning, at the single-cell level, during natural...
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It's exciting to attend my first Brain Initiative meeting and speak at the 10th Annual Brain Initiative Conference. All the neuroscientific work discussed here is so inspiring and motivating. The brain is so incredible! #BRAINConference #studyBRAIN @MGH_CNTR
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This was an amazing amount of effort which include multiple institutions and is described below. I was just happy to get to be a part of it. @MGH_CNTR @MGHNeuroSci @UCSDJacobs @UCSDNeuroSurg
https://t.co/4I4FU770o3
today.ucsd.edu
A thin film that combines an electrode grid and LEDs can both track and produce a visual representation of the brain’s activity in real-time during surgery–a huge improvement over the current state...
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Incredible work by Youngbin Tchoe, Shadi Dayeh, and team to make iEEG-microdisplays, thin film neural recording devices backed by tiny LEDs that light up to communicate brain activity, at Science Translational Medicine: https://t.co/SeIjErV50s w/ video!
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Super excited to announce that my preprint is finally out! Our study combines invasive electrophysiology, whole brain networks and neurotransmitter uptake to reveal a link between cortical beta and dopamine uptake in the brain. https://t.co/FNbVgbhHrv
biorxiv.org
Brain rhythms can facilitate neural communication for the maintenance of brain function. Beta rhythms (13–35 Hz) have been proposed to serve multiple domains of human ability, including motor...
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Happy to share a collaborative preprint with @KellerStanfordU on intracranial theta burst patterned stimulation with amazing analyses from @YuhaoHuangMD ! We found interesting dynamics across stimulation presentations with implications for neuromodulation.
biorxiv.org
Patterned brain stimulation is a powerful therapeutic approach for treating a wide range of brain disorders. In particular, theta-burst stimulation (TBS), characterized by rhythmic bursts of 3-8 Hz...
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