New group leader position in computational neuroscience @ Neurocentre Magendie, INSERM, Bordeaux! More info here: ⚠️ Application deadline: end of September 2025. @NCMagendie @Neuro_Bordeaux.

Thread of the study below:.

Heading to #COSYNE2025 ?. Check out the Beyeler lab poster tomorrow, presented by Archi Garg and Tanmai Dhani Reddy, 2 outstanding undergrads who did the computational analyses in our recently preprinted study!. More information below ⬇️ .@anna_beyeler @CosyneMeeting

Excited to have defended my PhD last Friday and extremely proud to be the first PhD student to graduate from the Beyeler Lab! 🎓.Grateful to @anna_beyeler for her invaluable support and mentorship during these 4.5 years and to my jury members for their constructive feedbacks ✨

On my way back after an incredible time in Berkeley and Tahoe for the Winter Brain conference! Feeling recharged and excited for my upcoming PhD defense in 2 weeks. Kudos to @petra_moce and @SMikulovic for the fun times!! ⛷️🏔️✨

And a special thanks to @NCMagendie and @Neuro_Bordeaux for their support!.

Big thanks to my PhD mentor @anna_beyeler for her support and all co-authors who contributed to this project! ✨ @dopaminergicmai, Giovanni Vardiero, Archi Garg, @daria__ri, @CelineNicolas2, @mnelly_dlm, @tinaxhabchi, @kris_neuro, @GjorJulijana, @yulonglilab and Emmanuel Valjent.

The coding reliability of anxiogenic areas is positively correlated with mice level of trait anxiety, and we observe a trend towards a positive correlation between the coding reliability of a negative tastants, and mice level of anxiety.

Systemic D1 activation heightens anxiety-related behaviors and dampens this coding dichotomy by increasing the coding variability for protected spaces while increasing the coding reliability for anxiogenic spaces.

Population dynamics and deep-learning analyses (@cebraAI @TrackingActions) of anterior insula single-unit recordings uncover distinct coding patterns of anxiety-provoking and safe environments, as well as tastants of positive and negative valence.

The amplitude of dopamine release onto D1+ neurons in the anterior insula, while mice are in anxiogenic spaces or receive mild foot shocks, is positively correlated with mice level of trait anxiety.

Pharmacological activation of D1 in the anterior insula is anxiogenic, suggesting a direct link between insular dopamine signaling and anxiety-related behaviors.

Few neurons co-express Drd1 and Drd2 mRNAs in the anterior and posterior insula, and the density of Drd1+ neurons in the anterior insula is twice higher among inhibitory neurons than excitatory neurons.

A high density of neurons express type-1 dopamine receptors (D1) in the insula, particularly important in the anterior insula, and seven times greater than the density of neurons expressing type-2 dopamine receptors (D2).

🚨Preprint alert 🚨. Excited to share my PhD work available on @biorxiv_neursci investigating how dopamine transmission in the anterior insular cortex shapes the neural coding of anxiety. here: 🧵(1/n)

First first-author paper submitted!!!! 🤓🫶🏼.Would not have been possible without a great mentor @anna_beyeler

To foster a more inclusive and supportive community, @network_alba is hosting a webinar on October 25th, focusing on mental health within the LGBTQIA+ community!! 🏳️‍🌈.

RT @fergilmills: Wanted to once again encourage anyone on the job market to apply @UUNeurobiology ! . Starting my lab here has been a dream….

RT @education_gouv: Sur proposition du Premier ministre, le président de la République a nommé madame Anne Genetet, ministre de l’Éducation….

Almost a year after launching the first workshop on open science in Bordeaux, @PLOS published the story of Fjola and Eduarda, initiators of this workshop! Take a look!.