Mutations in Argonaute proteins can significantly disrupt the miRNA biogenesis and functionality in target repression, and cause neurodevelopmental diseases. But how? Check out our new paper about modeling Argonaute Syndrome in C. elegans. 👇👇👇 https://t.co/3114QVxm1R

Mechanistic insights into RNA cleavage by human Argonaute2–siRNA complex | Cell Research

🚨ISRB Webinar - The Americas 🚨First one of the year! 🥳 Happening on January 17th, 12pm US East Coast Time, featuring Karen Echeverri from @MBLScience and Katy Loubnet-Senear from Phil Abitua's lab @Ohnolog @UW. Find all details at https://t.co/kfwpsG8XWZ

Today we introduce a new drug candidate for prion disease: a PrP-lowering divalent siRNA. A 4-year collaboration with @RTI_UMassChan enabled by @NINDSfunding IGNITE & URGenT mechanisms. https://t.co/Z10daPZGEw Our hope is to advance this to the clinic, wish us luck!

The latest @stemcellpodcast episode features Dr. Mansi Srivastava (@acoel_hofstenia) from @HarvardOEB and @MCZHarvard! She talks about her lab's work establishing the three-banded panther worm as a model system. 🎧 Listen now: https://t.co/k9WG5N7eKq

Thanks @BioRender The PDB builder function is really helpful 💗

Hofstenia miamia is an emerging model species for regeneration and embryology. We present this in-depth identification and developmental profiling of Hofstenia microRNAs. ⁦@acoel_hofstenia⁩ ⁦@ILublinsky⁩ #microRNA #Hofstenia

I’m delighted to share that I will be starting my lab @univmiami in Spring 2025! We will study cellular and developmental biology in non-bilaterian animals – cnidarians, ctenophores, placozoans, and sponges – to explore early animal evolution.

The @UMassChan community came together Wednesday to honor @NobelPrize recipient Victor R. Ambros, PhD, and his wife, senior scientist Rosalind “Candy” Lee: https://t.co/AyCUpteJkV Lee is the first author on a 1993 paper cited by the Nobel Committee. #NobelPrize #UMass #Worcester

#FridayFun we hosted @wachuregional students and parents to tour our Cryo-EM facility and several of our labs 😍 we had so much fun, and can’t wait to do it again!!!

Congratulations to Biology & Biotechnology Assistant Professor Karl-Frédéric Vieux on his award of $747,000 through the NIH’s Maximizing Opportunities for Scientific and Academic Independent Careers program! #wpi #wpibiologybiotechnology #bbt #biologybiotechnology #NIH

Congratulations to Victor Ambros on winning the 2024 #NobelPrize in Medicine for his groundbreaking co-discovery of #microRNA shared with Gary Ruvkun! His reflections on the AGO conference during Monday's press conference (min 36-42) https://t.co/YHuA2PQxun

When you win a @NobelPrize, you have to take a selfie or two. Congrats again to Victor R. Ambros, PhD, of @UMassChan and Gary B. Ruvkun, PhD, of @MassGeneralNews and @harvardmed, winners of the Nobel Prize in Physiology or Medicine for the discovery of microRNA. #NobelPrize

This is from my phone.

Congratulations to the brilliant funny and kind Rosalind (Candy) Lee 🎊🎉🥳🥳🥳the first author of the 1993 paper !

Victor R. Ambros, PhD, @UMassChan's Silverman Chair in Natural Sciences and professor of molecular medicine, has won a Nobel Prize. Media: Email UMassChanCommunications@umassmed.edu for news conference info and interview requests. #NobelPrize #BreakingNews #AdvancingTogether

So well deserved! I’m so proud that I had the chance to work with and learn from Victor!

PIWI-interacting RNAs: who, what, when, where, why, and how https://t.co/ebVRDaR84R

Pretty strong evidence of negative mental health effects of doing a PhD. Recent working paper by @EvaRanehill, @annahsandberg, Sanna Bergvall, and Clara Fernström. Paper link: https://t.co/7X4uEjzPCC

Why the octopus? Some of you asked this during the conference. Here’s the story: The null Arabidopsis ago1 mutant looks like a little squid. That’s why in 1998, Bohmert et al. named the gene after Argonauta argo, the shell octopus on Laura’s thesis cover. https://t.co/VPDYDuitzD

Victor Ambros and Daniel Cifuentes have made clear the importance of research in model organisms, like C.elegans 🪱 or zebrafish 🐟, to understand human disease 👏👏