vellamike Profile Banner
Mike Vella Profile
Mike Vella

@vellamike

Followers
853
Following
2K
Media
21
Statuses
849

Senior Director of Machine Learning at @nanopore

Oxford, England
Joined January 2009
Don't wanna be here? Send us removal request.
@jermdemo
Jeremy Leipzig
2 months
Public github repos of sequencing-related companies
3
15
73
@vellamike
Mike Vella
2 months
Yesterday in Malta the season for Dorado (Lampuki in Maltese) fishing opened, which is fantastic luck for me as I can enjoy a delicious dinner! My favourite basecaller and favourite fish share the same name.
0
0
2
@kirk3gaard
Rasmus Kirkegaard
3 months
@iiSeymour Impressive 🎉 I had to test that on our workstation and I can confirm that it is fast⚡️
1
2
8
@vellamike
Mike Vella
4 months
In this blog post, we show how chromatin accessibility can be profiled with minimal processing using nanopore sequencing – preserving native structure and capturing rich signal. Read it here:
Tweet card summary image
epi2me.nanoporetech.com
Functional epigenomics uses high-throughput sequencing data to study how epigenetic modifications…
0
3
15
@Stoibs11
Marcus Stoiber
5 months
Initial release of Pomfret for methylation assisted phase block joining for more contiguous phased assemblies without any additional library prep from @nanopore data. Such amazing work from @0xfxfxf ! #NanoporeConf https://t.co/7viZhUwt2a
0
6
25
@vellamike
Mike Vella
6 months
Really enjoyed this presentation by Gabriel Wagner-Lichtenegger (Medical University of Graz) showing how advances like Dorado Polish & V5 basecalling models make @nanopore data robust, reproducible & ready for genotyping. We’re just getting started! https://t.co/OKYwYgIsG2
0
5
12
@astar_gis
A*STAR Genome Institute of Singapore (A*STAR GIS)
6 months
🚀 Exciting News from Singapore! 🚀 Scientists at A*STAR's Genome Institute of Singapore (@astar_gis) have unveiled one of the world's largest long-read RNA sequencing datasets! 🌍🔬 This groundbreaking resource, known as SG-NEx, is set to revolutionize disease research by
0
11
24
@vellamike
Mike Vella
6 months
Telomere-to-telomere de novo assembly from standard ONT reads (LSK114, Simplex). A really exciting advance—makes high-quality assembly practical for population-scale sequencing! Preprint from @ChengChhy, @lh3lh3 and colleagues https://t.co/VpQMC0DfLA
Tweet card summary image
biorxiv.org
Telomere-to-telomere (T2T) assembly is the ultimate goal for de novo genome assembly. Existing algorithms capable of near T2T assembly all require Oxford Nanopore Technologies (ONT) ultra-long reads...
1
25
91
@vellamike
Mike Vella
8 months
Dorado polish can output assemblies in FASTQ format with quality scores. @rrwick 's analysis shows these scores are well correlated with base call reliability, meaning they could help reduce false positives in variant calling. https://t.co/4lwodOJxFo
rrwick.github.io
a blog for miscellaneous bioinformatics stuff
1
13
54
@ATinyGreenCell
Sebastian S. Cocioba🪄🌷
8 months
BRUH My plasmid samples arrived at 8am on a ***saturday*** Delivery to data in 50mins?!
7
6
234
@vellamike
Mike Vella
10 months
New Dorado release (v0.9.0) – and it's big! 🚀 Dorado polish (experimental) for improving draft assemblies – faster & more accurate than Medaka ⚡ Faster modified base calling models 🔧 Usability & accuracy improvements: PolyA, Barcoding, 6mA https://t.co/achk6TWa1Z
Tweet card summary image
github.com
[0.9.0] (16 Dec 2024) This major release of Dorado introduces several new features and enhancements. The polish command, currently experimental, is optimised for refining draft assemblies of human ...
3
39
102
@ChengChhy
Haoyu Cheng
11 months
Hifiasm 0.21.0 has been released. It now has a beta module for direct assembly of ONT R10 simplex reads. Initial tests with regular simplex reads show very promising results!
Tweet card summary image
github.com
Since Hifiasm-0.20.0 (r639): New Feature: Introduced a beta module for ONT assembly using ONT simplex R10 reads. To enable this feature, add the --ont option as shown below: hifiasm -t64 --ont -o...
3
45
109
@vellamike
Mike Vella
11 months
At @nanopore , we've used ML to achieve remarkable advancements in basecalling. Now, we're focusing on driving further improvements in consensus and variant calling, enhancing both speed and accuracy. Watch my colleague Rhydian update on our progress:
1
8
55
@AaronPomerantz
Aaron Pomerantz, PhD
1 year
Incredible milestone: @nanopore announces landmark UK Government partnership to advance genomics-driven healthcare innovation in the UK Initial program will launch rapid pathogen-agnostic surveillance across 30 NHS sites for public health & biosecurity https://t.co/X5efxxuoXh
0
6
17
@mamboitaliano__
Mambo Italiano
1 year
@JamesLucasIT The most incredible thing about Caravaggio is that it seems he invented CGI 500 years before it even existed 👇
1
8
47
@vellamike
Mike Vella
1 year
Direct native RNA (no cDNA!) sequencing from @nanopore is revolutionising RNA sequencing. It already achieves 19.4 Q accuracy and can detect modifications like m6a, m5c, pseudouridine and inosine. Watch my colleague Bronya Boydon explain how it works. https://t.co/hDfQiZYMvI
1
24
106
@vellamike
Mike Vella
1 year
In the last few months at @nanopore, we've made major strides in improving the accuracy of native DNA sequencing in bacteria, a challenging task due to bacterial DNA modifications. Watch my colleague Katherine Lawrence dive into the details: https://t.co/7C8WuGD6qH
1
25
78
@markwbudde
Mark Budde 🦕🏆
1 year
Thanks for posting this! We hear that our data quality and customer service are next-level, but we just put our heads down and focus on quality and innovation. Maybe it's time to hire a marketing team🤔
@DsSvetlov
VlaDSSvetlov
1 year
PSA: head-to-head comparison of @Psomagen and @plasmidsaurus whole-plasmid sequencing. 🦕🏆4:0 Context: sent 8 minipreps to Psomagen, 5 out 8 "failed". Got an unhelpful sermon about the need to correctly guess the size of the plasmid. Sent 4 "failures" to 🦕, all 4 sequenced.
0
1
20