Every single successful startup I know has persevered through at least one: - struggled to raise - co-founder split - failed first product/low early PMF - adversarial board/investors - layoffs These don’t typically hit the headlines, but almost every success has at least one.

I am excited to announce what I’ve been working on for the past 2 years. General Control is a mandate to develop programmable therapies that make durable, reversible adjustments to gene expression - epigenetically activating or silencing multiple targets at once. In the past 16

In the dot-com boom of 1990's it was commonly believed 90% of the startups ultimately failed. In fact, 48% of startups survived.

“Tech and finance have never been so deeply intertwined. The staggering sums of capital needed to fund AI has pushed the tech industry to go where it has never gone before in the hunt for capital.” - Ken Brown, Editor, The Information Finance

Naming a startup is way more important than most people think.

we raised a $13m seed round from 120+ of Silicon Valley’s top investors for @mastra_ai, the leading TypeScript agent framework

Two years ago today, we shut down Braid, and I wrote a long post about it that went unexpectedly viral. The idea of a multi-user financial account kept nagging at me though, and in that time, no one else built a good one. So we got back to work. Today is the day. We're

Nigam Arora returns to the Schwab Network and weighs in on job cuts in banks, saying AI will be a factor to increase productivity and could be the “fly in the ointment” for that segment of the labor market. $KBE $C $JPM $BAC

Teaming up with Terrence to study what early employees who've joined multiple great startups look for. Know anyone who's joined 2+ great companies super early, before it was obvious the company was great and would be successful? Tag them 🙏

Venture Capital is over-discussed relative to its significance.

The @browsercompany just signed a merger agreement to be acquired. We will remain independent. Our focus is Dia. I’ve written and rewritten this post more times than I’d like to admit, but what I keep coming back to is simple: the work continues, and we’re grateful for this

It’s entirely plausible that the typical technology company will need 25-33% less people going forward. That’s a modest premise that would have sweeping implications.

There is a tiny population of early employees who repeatedly select great startups. They are under-discussed and under-studied.

VCs commonly underestimate how much founders dislike fundraising. Many founders will simply take an early, reasonable offer, just to be done. Speed and decency wins a surprising number of deals.

Here comes “the last prediction market” 🔥🔥🔥

Multi-stage VC are now dominating seed. 1. Multi-stage VC funds are 70% more active than boutique/seed funds (258 v 151). 2. Just 4 VC funds have invested in more seed deals (152) than all the boutique/seed funds combined (151). 3. Many top seed funds are not on this list.

"The world is often unkind to new talent, new creations. The new needs friends." - Ratatouille

In today’s market, VCs are more likely to fund the 10th company in a category as opposed to the 1st.

Founders occasionally notice they have innate founders working for them. After trying to keep them in their own company, the best founders not only set them free, but also help them fulfill their own life’s work.

Pre-seed is venture’s highest art.

This is Figma's first logo, which I still love. It was designed by @benbarry , a legend - who also designed the logo for OpenAI, Cursor, Sierra, amongst others!

Figma's original seed pitch, and how it still holds today. Congrats @zoink and Evan and all the Figmates @figma - what an incredible company, community and moment!!

Today, we’re announcing @TrustVanta's Series D and new valuation – $4.15 billion – led by @Wellington_Mgmt alongside @sequoia, @ycombinator, @CrowdStrike, @GoldmanSachs, @jpmorgan, @craft_ventures, and @Atlassian. Vanta’s mission is to help businesses earn and prove trust.