Timothy L. Downing
@timothy_lamont
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Associate Professor of Biomedical Engineering @ UC Irvine
Joined September 2012
Our paper with with @timothy_lamont and @ASpakowitz is out in Nucleic Acids Research!
academic.oup.com
Abstract. The 3D organization of the genome—in particular, which two regions of DNA are in contact with each other—plays a role in regulating gene expressi
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The NSF funded BEST program is accepting applications! UCI Graduate Trainees will gain ✅Interdisciplinary research skills ✅Hands-on mentoring ✅Career prep and MORE! Become a leader in innovative health solutions! For additional details visit: https://t.co/8jhJCly3Pt
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We hope MPATH will open new doors for epigenetic research, revealing dynamic chromatin and transcriptional regulation across the cell cycle. Check out our preprint here:
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- A powerful tool to extract temporal information from existing long-read datasets - A novel approach towards discerning allele-specific differences in replication timing - e.g., linked to X chromosome activity.
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Here, we demonstrate how MPATH offers: - Simultaneous tracking of CpG methylation & hydroxymethylation, including at regulatory elements - New insights into the timing of DNA methylation/demethylation turnover ...
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To address this, we developed MPATH (Methylation Pseudotime Analysis Through read-level Heterogeneity)—a label-free, high-resolution method that leverages long-read CpG methylation patterns to infer DNA strand maturity.
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Technological approaches to track epigenetic modifications through the cell cycle are often limited in sequence resolution and/or require additional DNA labeling or conversion steps.
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I'm thrilled to share a new preprint from our lab! 🧬 Congrats to Annie Trinh 🌟 and our collaborators on this exciting work! https://t.co/q8HRnxcUj4
#Epigenetics #DNAReplication #LongReadSequencing #MPATH #ChromatinDynamics #Preprint
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I look forward to co-moderating this Special Session with @songli_UCLA on "Epigenetic Engineering of Cells" at the @BMESociety annual meeting in Baltimore this week. The program includes talks from Vadim Backman, G.V. Shivashankar, and Ryan Stowers. Hope to see you there!
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I'm thrilled to share our collaborative work on how polymer physics + nucleosome placement predict long-range DNA contacts, led by Jack and the @allardlab. Please enjoy!
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63 years of NHLBI support... just remarkable. Dr. Shu Chien's scientific achievements are eclipsed only by his great warmth, decency, and generosity. We bioengineers are fortunate to have him as a leader and role model. Congrats! @ucsdbe
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Attending 24th UC Systemwide Bioengineering Symposium @ucsdbe . Dr. Shu Chien gave an opening remarks, and @timothy_lamont @uci_bme gave a wonderful keynote.
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Outstanding keynote lectures from Dr. Dongjin Lee @CIRMnews and Prof @timothy_lamont @uci_bme on stem cells and reprogramming 🧫👏 #BIC2024
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Y’all better listen to this icon’s stories. Some of you want to engage in a nostalgia that erases the horrors and degradation of American apartheid in order to tell a feel-good story of progress. Reggie Jackson refused to allow it. We cannot move on as so many want until we tell
Chilling stories of enduring racism from the legendary Reggie Jackson in response to @AROD's question about returning to Rickwood Field. "I wouldn't wish it on anybody." Tells how people threatened to burn down the apartment he was staying at. @FOX4 @MLBONFOX
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Congrats to Tim Downing for being appointed Chair for Diversity in Engineering Education! He's a National Institutes of Health New Innovator and was named to Forbes 30 under 30 in 2017. He's an associate professor of biomedical engineering. 🤘👍 https://t.co/z3GD0R6kOq
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A lot of good things are happening in the Adams Lab, one highlight is a new paper delving into the nuanced landscape of cancer phenotypes using electrical impedance spectroscopy. https://t.co/5z5fcMR1fT
#InnovationInProgress
mdpi.com
Prostate cancer is the second leading cause of death in men. A challenge in treating prostate cancer is overcoming cell plasticity, which links cell phenotype changes and chemoresistance. In this...
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PLEASE RETWEET!!! @ucsdbe and @UCSDJacobs is hiring for multiple Assistant Professor positions in #Bioengineering. Come join our diverse group of amazing faculty, students, and staff! #DiversityInSTEM #AcademicChatter #AcademicTwitter
https://t.co/9I3FJVhRVu
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