Simone Park
@simpak
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CRI Fellow @WherryLab @Penn 🇺🇸 | previously @LMackayLab 🇦🇺 | @ForbesUnder30 '22 | T cells in infection, cancer and everywhere in between 👩🔬🌜
Philadelphia, PA
Joined March 2009
Are all skin TRM cells created equal? Beyond excited to share our new paper in @ScienceMagazine, where we show diverse CD8+ TRM use distinct molecular pathways to develop and persist in skin, which we can target to fine-tune the skin-immune landscape🧵👇🏻
science.org
Functionally distinct memory T cells navigate divergent developmental pathways to establish residency of the skin
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RT @jane__huang: Excited to share my graduate work from the @EJohnWherry lab on the molecular mechanisms locking in the differentiation fat….
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RT @LMackayLab: Our latest study, led by @susanna_c_, shows CD47 × PD-L1 bispecific antibodies enhance tumor-resident CD8+ T cell responses….
onlinelibrary.wiley.com
Bispecific antibodies targeting CD47 and PD-L1 (CD47 × PD-L1 BisAb) demonstrate efficacy against a range of solid cancers, but the effect of combined innate and adaptive immune activation on protec...
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RT @LMackayLab: 1/ 🚨 Hot off the press! 🚨Our new paper, led by @ObersAndreas & @maxevrard, is now live in @ImmunityCP! 🧬 Curious how CD8+ t….
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RT @EJohnWherry: Very happy to share this new work on LAG3 and PD1. Has been a long road to (begin to) sort out how LAG3 functions in CD8 T….
cell.com
LAG-3 loss modulates PD-1 deficiency by regulating TOX transcription factor expression in exhausted CD8+ T cells and their responsiveness to cellular stress in target cells.
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and also excited today to see @divijmathew paper from the lab online now in @ScienceMagazine , a mammoth effort exploring how JAK inhibition modulates checkpoint immunotherapy responses! congratulations Divij!!!
science.org
Persistent inflammation driven by cytokines such as type-one interferon (IFN-I) can cause immunosuppression. We show that administration of the Janus kinase 1 (JAK1) inhibitor itacitinib after...
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so excited to see this story from the amazing @ScientistBecs and @SunLab_Official out this week! super cool data on how dietary restriction can modulate NK cell function and cancer immunity, massive congratulations to my 🇦🇺 sci-sister Bec! 🙌💫🍾 you are awesome!.
Thrilled to have this story out online @ImmunityCP!! Together with @SunLab_Official, we highlight how dietary fasting improves NK cell anti-tumor immunity and examine the tissue-specific processes that drive these improved responses 🧵
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congratulations Emma, Thomas and co. on a really cool study on how CD4 T cells control melanoma! excellent to see this work out in print 🙌🥳.
Excited to share our research that describes a variety of mechanisms that CD4+ T cells can employ to target melanoma!.
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thank you for featuring our study on the Doherty Podcast this week @TheDohertyInst ! was great to talk science 🤓🧬👩🔬 follow the link below to listen!!.
📣New podcast episode has dropped! 'Autoimmune skin conditions could be treated by targeting T cells' with @simpak.🎧Find us wherever you listen to your podcasts or via our website: @UniMelbMDHS @TheRMH @LMackayLab
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RT @LMackayLab: 🌟Excited to share our latest work on how functionally distinct skin TRM utilise different pathways to establish residency,….
science.org
Functionally distinct memory T cells navigate divergent developmental pathways to establish residency of the skin
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thank you also to @theheraldsun and @RNBreakfast for spotlighting our work yesterday! 🌟🫶.
abc.net.au
A team of Australian scientists has made a breakthrough discovery that has implications for the way we treat some auto-immune skin conditions. The discovery may pave the way for treatment for...
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🙌 @susanna_c_ explaining the implications of our research to @7NewsMelbourne yesterday!.
Melbourne researchers have made breakthrough discoveries that may help those suffering from skin conditions such as psoriasis. They found new molecules that control disease-causing immune cells in the skin and can be targeted without impacting the barrier that fights off cancer.
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And last but not least: to @LMackayLab herself -- for pitching me this project when I was bored of measuring tumors, all your support, and for taking this science all the way to the finish line with me. We finally made it! 💫🏆
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Top of the list on my thank-you's is the one and only brilliant @susanna_c_- not everyone gets to experience the happiness of sharing a co-first author paper with their best friend, and I feel incredibly lucky to do it with you 🌟🌟
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Thank you for making this paper happen, despite the bouts of 10x-food-poisoning 🧬🤢, 10x-COVID-positives 🧬😷 and general experimental/other setbacks that life tried to throw in the way!
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I have never been so grateful to work with so many wonderful people 🤩😻 in @LMackayLab and beyond @yannoudesbois @TomBurn8 @maxevrard @Stephane_Guil @maleikaosman @DrAliZaid @Nick_Collins11 @SeongJiHan @ObersAndreas
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Postdoc-ing across two opposite timezones and 10,000 miles (literally) is no easy feat! Two flights back and forth to Aus for revisions ✈️✈️ and many many mice 🐭 later,.
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Submitted in 2021 (despite what it might say on the tin). and it would be several more years, and many miles distance between me and @LMackayLab before we would finally see it in print!.
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This project is a tale of perseverance from all involved, starting in 2017 when I was a PhD student @TheDohertyInst and continuing into my short postdoc @LMackayLab. We were almost ready to submit in late 2019. and then 2020 happened! 😷.
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It certainly wouldn't have been possible without the help of each of them, especially @BelkaidLab for providing the S. epi bacteria + insight and @alexwellsies for performing critical experiments at the NIH, especially during the pandemic and after my move to 🇺🇸!.
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This paper has been a mammoth effort, involving so many amazing scientists and colleagues who have contributed to this study! @LMackayLab @BelkaidLab @Mielke_Lisa @SMuellerLab @WEHI_research @TheDohertyInst @FedUniAustralia.
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