Sheera Adar
@sheeradar
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Joined November 2015
My PhD home….
This is the most Israeli thing I’ve seen. Taken at the Weizmann Institute of Science, following the Iranian attack.
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It was really cool to see that repair efficiency is a stronger influence than damage-sensitivity on the final mutational profile. But still: It's best not to smoke!.
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So proud of @ElishevaHeilbr1 for leading this project. It was wonderful working on this collaboration with @danatse_ @CohenYuval2 Hana Wasserman and @RalucaGordan.
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New paper alert! The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and DNA repair efficiency
academic.oup.com
Abstract. Lung cancer sequencing efforts have uncovered mutational signatures that are attributed to exposure to the cigarette smoke carcinogen benzo[a]pyr
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RT @Marteijnlab: Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24!. You can pre-register t….
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RT @youngAcademyIL: האקדמיה הצעירה מזמינה אתכם, דוקטורנטים דוקטורנטיות ישראליים מכל תחומי הדעת לקראת סוף הדוקטורט, להצטרף למפגש שמטרתו להצי….
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Things you do when you don't have a time machine. Congrats @lirancarmel and @meshorer1.
Our latest paper is out in @NatureEcoEvo: Inferring DNA methylation in non-skeletal tissues of ancient specimens. A major challenge in studying DNA methylation in ancient samples is that it is tissue-specific. 1/11.
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RT @ayoubnlab: Thrilled to share our latest article in Trends in Genetics!.Ever wondered why RNA processing factors are recruited to DNA DS….
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KDAC inhibition increases chromatin accessibility – but this isn’t why there’s more DNA damage. Also: despite the increased accessibility, nucleotide excision repair is repressed. Always fun to get results you didn’t expect!.
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The drug creates more DNA damage and kills cancer cells more efficiently than cisplatin. It extended survival in a mouse cancer model, and cells did not develop resistance after long-term exposure.
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New preprint! A fun collaboration lead by Yaara Negev Korem, with Ron Kohen and Dan Gibson from @PharmacyHUJI and Ori Wald from @Hadassah_Med ! We synthesized a novel cisplatin-based prodrug, in which cisplatin is fused to two KDAC inhibitors. Check it out: .@IMRIC_HUJ @Hujimed.
A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance #biorxiv_molbio.
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RT @ItamarHarel: 🚨 Please RT.Thrilled to share our new study in turquoise killifish, revealing that mutating cGAS-STING can rescue key defe….
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RT @yotam_d: Our paper is now official out, see the new and improved version at: Congratulation to the wonderful @E….
science.org
SMCHD1 loss drives FSHD pathogenesis by disrupting DNMT3B splicing, leading to D4Z4 hypomethylation and DUX4 overexpression.
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RT @MichalRabani: Our paper is now officially out: A great collaboration with @JeffreyAFarrell, and a major effort….
nature.com
Nature Communications - This study analyzes the embryonic replacement of maternally contributed mRNA with new mRNA in single cells and shows dynamic spatio-temporal regulation of maternal mRNA...
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Nice to see this out. Congrats to @HibaHassanain @danatse_, @tamarhaco and the rest of the (twitterless) team! Based on the method first developed by @BenVanHouten2 and Joel Meyer: An easy-to-implement DNA damage detection method we hope will be useful.
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RT @schumacherbj: 🔥🔥🔥Our review article on 🧬🧬🧬Genome Instability and DNA Repair in Somatic and Reproductive Aging @spanier55 and @SiyaoWang….
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