Sheera Adar
@sheeradar
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My PhD home…
This is the most Israeli thing I’ve seen. Taken at the Weizmann Institute of Science, following the Iranian attack.
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It was really cool to see that repair efficiency is a stronger influence than damage-sensitivity on the final mutational profile. But still: It's best not to smoke!
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So proud of @ElishevaHeilbr1 for leading this project. It was wonderful working on this collaboration with @danatse_ @CohenYuval2 Hana Wasserman and @RalucaGordan.
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New paper alert! The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and DNA repair efficiency https://t.co/uKPBE6QumT.
academic.oup.com
Abstract. Lung cancer sequencing efforts have uncovered mutational signatures that are attributed to exposure to the cigarette smoke carcinogen benzo[a]pyr
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Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: https://t.co/BrfJ00RBPu Registration will open by June 2025
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Things you do when you don't have a time machine. Congrats @lirancarmel and @meshorer1
Our latest paper is out in @NatureEcoEvo: Inferring DNA methylation in non-skeletal tissues of ancient specimens. A major challenge in studying DNA methylation in ancient samples is that it is tissue-specific. 1/11
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Thrilled to share our latest article in Trends in Genetics! Ever wondered why RNA processing factors are recruited to DNA DSBs? We propose two explanations that shed novel insights into the functional significance of RNA processing factors at DSB sites. https://t.co/smyTmGdm3z
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KDAC inhibition increases chromatin accessibility – but this isn’t why there��s more DNA damage... Also: despite the increased accessibility, nucleotide excision repair is repressed. Always fun to get results you didn’t expect!
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The drug creates more DNA damage and kills cancer cells more efficiently than cisplatin. It extended survival in a mouse cancer model, and cells did not develop resistance after long-term exposure.
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New preprint! A fun collaboration lead by Yaara Negev Korem, with Ron Kohen and Dan Gibson from @PharmacyHUJI and Ori Wald from @Hadassah_Med ! We synthesized a novel cisplatin-based prodrug, in which cisplatin is fused to two KDAC inhibitors. Check it out: @IMRIC_HUJ @Hujimed
A Novel Cisplatin-Based Prodrug Inhibits Lysine Deacetylases, Suppresses Nucleotide Excision Repair, and Overcomes Resistance https://t.co/hapqMyH13o
#biorxiv_molbio
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🚨 Please RT Thrilled to share our new study in turquoise killifish, revealing that mutating cGAS-STING can rescue key defects in DNA damage repair syndromes! Findings offer a potential therapeutic target, with possible implications for aging. Read here: https://t.co/vUANy9Nmx4
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Our paper is now official out, see the new and improved version at: https://t.co/h6ET7mO12n Congratulation to the wonderful @EdenEngal_, @MaayanSalton and team.
science.org
SMCHD1 loss drives FSHD pathogenesis by disrupting DNMT3B splicing, leading to D4Z4 hypomethylation and DUX4 overexpression.
Happy to report our latest results on the role of SMCHD1 in facioscapulohumeral muscular dystrophy (FSHD). A very close and fun collaboration with @MaayanSalton, this work was led by our amazing joint MD/PhD student @EdenEngal_ 1/2 https://t.co/VNxjXcBp7R
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Our paper is now officially out: https://t.co/T7Lb4yCIHE A great collaboration with @JeffreyAFarrell, and a major effort by our own @fishman_lior
nature.com
Nature Communications - This study analyzes the embryonic replacement of maternally contributed mRNA with new mRNA in single cells and shows dynamic spatio-temporal regulation of maternal mRNA...
How do pluripotent cells assume specialized molecular identities within an embryo? Check out the lab’s first preprint! A great collaboration with @JeffreyAFarrell and a major effort by our own Lior Fishman (1/12)
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Nice to see this out. Congrats to @HibaHassanain @danatse_, @tamarhaco and the rest of the (twitterless) team! Based on the method first developed by @BenVanHouten2 and Joel Meyer: An easy-to-implement DNA damage detection method we hope will be useful https://t.co/zwAo2HE0uy
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🔥🔥🔥Our review article on 🧬🧬🧬Genome Instability and DNA Repair in Somatic and Reproductive Aging @spanier55 and @SiyaoWang1005 @CECAD_ @MPIAGE @imbmainz @UKKoeln @UKKoeln
annualreviews.org
Genetic material is constantly subjected to genotoxic insults and is critically dependent on DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma only requires...
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