Huanglab
@rhuanglab
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Chemical Biology and Medicinal Chemistry Lab focusing on methyltransferases and protein N-terminal acetyltransferases at Purdue University College of Pharmacy
West Lafayette, IN
Joined February 2018
The review from Ying @Purdue_MCMP on Decoding the protein methylome is out now. Thank @ElsevierConnect for inviting us to contribute. Congrats @XDavidLiLab1 for a well-deserved Young Investigator Award
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Our recent publication led by Ying Meng @Purdue_MCMP explores how NTMT1-mediated Na-methylation affects the stability and interaction of PAD1, offering insights into protein N-terminal methylation. Great contributions on proteomics by Wang lab at UCR.
pubs.acs.org
α-N-Methylation (Nα-methylation), catalyzed by protein N-terminal methyltransferases (NTMTs), constitutes a crucial post-translational modification involving the transfer of a methyl group from...
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RT @ACSINLocal: Here is the speaker line-up for the MEDI Division at the ACS Indiana Local Section's "Exceptional Leaders Conference" on Ap….
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RT @gunda_i: Please read our editorial with contributions from female medicinal chemists and what inspires them. ht….
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Thank my mentors Rick Borch and Phil Cole, colleagues @Purdue_MCMP , collaborators, and friends who have inspired me over the years. Of course, a big shoutout to my family for their unwavering support and trust. Boiler up!.
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I am incredibly grateful and honored for this recognition. Sincere appreciation to all dedicated coworkers in the @rhuanglab, past and present. Thank @DeanEricBarker and our head @zyzhanglab for their support and advocate.
Congratulations to Rong Huang, who was ratified today as the Evanson-McCoy Professor by the Purdue Board of Trustees! #pharmacysgiantleap
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RT @purduepharmacy: Congratulations to Rong Huang, who was ratified today as the Evanson-McCoy Professor by the Purdue Board of Trustees! h….
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Interesting in learning updated research in protein arginine methylation? You still have time to register the FASEB catalyst conference on protein arginine methylation. We have great speakers lined up on Feb 21-22, 2024.
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Cheers to Ying, @IrediaIyamu, and Noha @Purdue_MCMP. Chemoproteomic Studies of NNMT Bisubstrate Inhibitors Uncover the Improved Selectivity of Unconventional SAM Analogue Moiety @ACSBioMed
pubs.acs.org
Unconventional S-adenosyl-L-methionine (SAM) mimics with enhanced hydrophobicity are an adaptable building block to develop cell-potent inhibitors for SAM-dependent methyltransferases as targeted...
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Farewell lunch for Dr. Iredia Iyamu who started his own lab as an Assistant Professor @UKansasPharmacy on December 1. We appreciate his contributions and are so thrilled for his success. All the best on the new journey.
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RT @ChemBioSociety: #ICBS2023 Proud to collaborate with @EuroMedChem (EFMC) on ‘Synthetic Biology for Medicinal Chemistry' session! Chaired….
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RT @Purdue_MCMP: @Purdue_MCMP is hiring for Faculty Positions in Translational Neuroscience and Chemical Biology ht….
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Had a blast with AI and computational modeling to accelerate drug discovery session this morning at #ACSFall2023 @AcsMedi Thank my co-organizers René Rahimoff and Matthew Landry. Great talks by all seven speakers.
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Look forward to a @AcsMedi session #ACSFall2023 featuring talks from Hannes Stärk, Madeleine Kieffer, Francesco Rianjongdee, César de la Fuente, Yuanfang Guan, and Pat Walters. It'll have something for everyone. All speakers will present in-person.
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RT @conway_group: Looking forward to the @ACS_DivBioChem session on The Intersection of Biological and Medicinal Chemistry at #ACSFall2023.….
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@dengyouchao1201 Many thanks to Iredia and our long-time collaborators in the Min lab @thesgconline.
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Excited to share our serendipitous discovery of a benzyl urea moiety to induce a hydrophobic binding pocket adjacent to the SAH binding site. Plus, our "T-shaped" analog YD290 potently inhibits type I PRMTs. Kudos to @dengyouchao1201 for his great work.
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Excited to share our SAR studies on Cell-Potent NNMT Bisubstrate Inhibitors led by Dr. Iredia Iyamu. A big shout to Tianqi Zhao for his contribution @Purdue_MCMP @ACSBioMed
pubs.acs.org
Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme implicated in multiple diseases, making it a promising therapeutic target. Building upon our recently reported NNMT inhibitor II399, we...
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