Zhang Lab
@zyzhanglab
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The Zhang Lab at Purdue University studies, characterizes and targets Protein Tyrosine Phosphatases of all forms
West Lafayette, IN
Joined August 2021
pleased to share a latest finding from the lab that uncovers an unexpected off-target autophagy blockade by SHP2 allosteric inhibitors that can be exploited for improved treatment of RAS-driven cancers.
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Today, Yiming Miao successfully defended his thesis on Drugging the Undruggable Protein Tyrosine Phosphatases, the Expected and Unexpected. Congratulations Dr. Miao!
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Yesterday, Brenson Jassim defended his thesis on Design, Structure-Activity Relationships, and Biological Evaluation of Small Molecule PTPN22. Congratulations Dr. Jassim!
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Check out our new reviews on targeting PTPs as a cancer immunotherapy ( and drugging PTPs through targeted protein degradation (!.
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Two in a row! Check out our recent publications on PROTACs targeting TCPTP and SHP2 as promising cancer treatment!.
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RT @WISH_TV: Cancer researchers had two years of hard work to synthesize the compound known as TP1L. Could it revolutionize cancer treatmen….
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RT @purduepharmacy: Purdue pharmaceutical compound sounds the alarm on cancer cells and unleashes T cells #pharmacy….
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Two Ph.D.s in one week! Colin Carlock just defended his thesis on validation of PRL as therapeutic targets using novel animal model systems. Congratulations Dr. Carlock!
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Frederick Nguele Meke defended his thesis on studies of phosphates of regenerating liver (PRLs) and became the first PhD from our lab at Purdue! Congratulations Fred!
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Congratulations to Jingmei and Frida for passing the OP! Job well done!
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Had a lot of fun at #ACSSpring2023! Glad to present our research to attendees from around the world and receive the mini grad student from @WatersCorp
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Targeting PTPs via active site has been a long existing problem but not for Jiajun, Jinmin, and Yiming. Congrats on the publication on PTP1B/TCPTP PROTAC!
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