石黑大雄
@ppa007hot
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RT @MiaoYansong: We introduce a new tool to study F-actin remodeling, ADPact, a peptide sensor of ADP-actin. Unlike Lifeact and Phalloidin,….
pnas.org
The dynamic organization of the actin cytoskeleton, crucial for numerous cellular processes, is intricately regulated by the nucleotide state of ac...
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Majority of data never get the opportunity to be published. This is F-actin clearly organized in two modes, clusters or meshes, possibly mediated by formins and Arp2/3.
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RT @cell_club: A hollow TFG condensate spatially compartmentalizes the early secretory pathway.
nature.com
Nature Communications - The authors show that protein TFG self-organizes to form a hollow sphere that helps to guide and spatially organize bidirectional transport at a critical junction between...
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RT @TrevorCampbell_: There are so many weird Biology quirks that I somehow missed before and am only just finding now. Apparently transl….
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RT @ShorterLab: Live-cell quantification reveals viscoelastic regulation of synapsin condensates by α-synuclein | Science Advances https://….
science.org
Direct material quantifications reveal a liquid-to-solid transition of synapsin condensates in vitro and in live cells.
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RT @SergioCruzLeon1: Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬.w/ @jpkreysing, Johan….
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RT @zacsimile: MINFLUX works well in theory, but system and sample imperfections can lead to suboptimal resolution. To address this, @Jonas….
biorxiv.org
MINFLUX is a super-resolution microscopy technique with remarkable resolution for imaging and tracking. Its optical resolution is well understood under idealized conditions, but because of system...
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RT @cell_club: Cell membranes sustain phospholipid imbalance via cholesterol asymmetry: Cell
cell.com
This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymme...
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RT @bewersdorflab: 4Pi-SMS and pan-ExM reveal, in a close collaboration with the Rothman lab, a surprising tetraplex organization and self-….
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Golgi apparatus is a daunting target for imaging for its uniquely stacked morphology throughout 3D space. To see how we combined super-resolution microscopy and biochemistry to study Golgi, please read our manuscript with all supplementary in BioRxiv:
biorxiv.org
Golgin proteins have long been suspected to be organizers of the Golgi stack. Using three-dimensional super-resolution microscopy, we comprehensively localize the human golgin family at the rim of...
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Interestingly, some of purified golgin proteins have strong tendency to self-assemble into long filaments and bands. Those golgins happen to be located at the rim! We propose a novel “outside-in” physical model to be the framework of Golgi ribbon architecture.
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The Golgi apparatus has been described as cis, medial, and trans, with vaguely defined boundaries from a membrane-centered perspective. Here we shows that from a protein-centered view golgins form a digital code, arranged into 4 distinct layers on the outer surface only.
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I am happy to share our 5-year's work of manual mapping of all the native proteins in the golgin family, providing the highest resolution atlas of the Golgi apparatus to date! Yes, we can distinguish proteins at different cisternae.
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RT @immazzystar: 写了一篇很长的DeepSeek R1科普文，从AlphaGo战胜李世石出发，到ChatGPT类模型的训练困境，和我看到DeepSeek R1真正的闪光点，一路贯穿下来竟然写的心潮澎湃。. 特别是在OpenAI和Claude的各种操作和言论后，让….
mazzzystar.com
我本想写一篇关于 DeepSeek R1 的科普文，但发现很多人仅仅把它理解为 OpenAI 的复制品，而忽略了它在论文中揭示的"惊人一跃"，所以，我决定重新写一篇，讲讲从 AlphaGo 到 ChatGPT，再到最近的 DeepSeek R1 底层原理的突破，以及为什么它对所
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RT @anupap85: Very excited to share my work from the Bogan lab on a novel regulatory mechanism in the early secretory pathway. Lots of surp….
biorxiv.org
The endoplasmic reticulum (ER)-Golgi Intermediate Compartment (ERGIC) is a distinct compartment in mammalian cells, which forms in part by homotypic fusion of ER-derived vesicles and gives rise to...
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RT @YinyinZhuang: Excited to share my first preprint in @XiaoyuShi2 lab! A 3D stack ExM image of cell is attached here to share you with my….
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RT @wuyuesanren: 一位朋友做了一件我特别想做、但实在是懒得去做的事儿：在日本这个自由的社会，创立一家简体中文出版社，把国内有思想的简体中文作者无法出版、或者只能阉割出版的书原样印出来。. 目前已经出版了3个品种，书都是放在内山书店、东方书店、光和书房、单向街书店….
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