📢The @IMI_EPND Hub launches today! With powerful new features for #neurodegeneration researchers and cohorts, the EPND Hub streamlines discovery, access, sharing and analysis of biosamples and datasets 🤝 Learn more and join the EPND community ➡️ https://t.co/obbE09DYZt

📢 Announcing a new edition of our e-Newsletter! We're delighted to share the latest updates from EPND, including a special Catalogue feature, research news, partner interviews and much more 📰 Read the newsletter ➡️ https://t.co/zRINGbWkd8

Breaking down #Alzheimers disease into 5 subtypes by proteins in cerebrospinal fluid, with distinct genomic profiles and molecular processes https://t.co/oFKy5aHSGP @NatureAging @pjvisser123 @bettytijms

Cerebrospinal fluid proteomics parsed #Alzheimersdisease into five subtypes. Each was associated with distinct genetic risk variants, degrees of brain atrophy, and disease duration after diagnosis. @amsterdamumc @MaastrichtU

#Biomarker assays must be validated to ensure they provide reliable, accurate results 📄 To guide researchers, our validation SOP details specific procedures for technical validation of fluid-based biomarkers🩸 (3/5) https://t.co/GjWPjenCv1

Our report on best practices for biobanking draws on the expertise of leading #biomarker researchers and biobanks 🧪 Read our guidance on certifications, clinical procedures & laboratory protocols, covering the A-Z of biobanking activities➡️ (4/5) https://t.co/ofuH2nvMkL

Collaborative research can accelerate the discovery & validation of neurodegenerative disease #biomarkers. So, to support researchers, we are developing guides & protocols to complement our technical infrastructure for sample & #DataSharing. Read more about our SOPs!⤵️ (1/5)

Een #concert om niet te vergeten: ma. 15 mei bundelen topmusici en topwetenschappers hun krachten voor meer aandacht voor de ziekte van Alzheimer: optredens van o.a. pianiste @ninogvetadze en jong talent uit Oekraïne (9 jr.) https://t.co/t6XBFCCjn3 📷@SarahWijzenbeek & Daan Brand

With support from @IHIEurope, we’re building a platform and community to fuel new discoveries and accelerate the development of diagnostics and treatments. Together, we can change the future of #Neurodegenerative diseases.

Read more in @FrontNeurosci on how @imi_epnd and partners are addressing challenges hampering large-scale research for neurodegenerative diseases. https://t.co/dmqnFAngUW

Research by @bettytijms 's team @pjvisser123 @AlzheimerAms @SEngelborghs : "CSF Proteomic #Alzheimers #Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals" #Cognitive #proteomics 🔗 https://t.co/reAERgxcuL #mdpiproteomes via @Proteomes_MDPI

Data and sample sharing as an enabler for large-scale biomarker research and development: The EPND perspective

A fantastic #milestone to mark the first year anniversary of @imi_epnd. Many thanks to all the partners in this consortium for making this happen. Looking ahead to the best year. @AlzheimerEurope @IHIEurope @pjvisser123 @AlzData

Proud to announce the #EPND Cohort Catalogue! Search the catalogue and filter by metadata on research participants, #biosamples, cognitive data, & more. Discover 60+ European cohorts, and create new collaborations for your #neurodegeneration research. ➡️ https://t.co/lghW4ey1Yt

In #Alzheimers disease, levels of CSF tau are related to neuronal plasticity protein concentration. Individuals with high tau show increased levels of these proteins while those with normal tau have decreased levels. Perhaps treatment of AD must differ depending on tau levels?

CSF tau levels reflect much more than neurodegeneration only: see @pjvisser123 latest CSF proteomics study in EMIF-AD MBD @IMI2_NEURONET @imi_epnd & ADNI; #memorabel @ZonMw

Updated prevalence estimates of amyloid abnormality from the Amyloid Biomarker Study Group now available including data of 19097 participants from 85 cohorts!

In pairs of identical twins, tau tangles accumulate in strikingly similar patterns, but stage of #alzheimersdisease and lifestyle can still make a difference. @vuamsterdam https://t.co/JRXRxcT3fl

To join the community and get the latest news, visit our website. https://t.co/EpulPfVexT #WeAreEPND #EPND

#WorldAlzheimersDay is an inspiring reminder that hope is on the horizon. Brilliant scientists all over the world are working hard to stop Alzheimer’s disease—and they’re making terrific progress.