Peter Grayson
@petercgrayson
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Vasculitis doctor and researcher, father of three girls, diehard Celtics fan, musician
Joined January 2019
I’m out of here. Will find different platforms to share research results. ✌️.
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RT @NIH_NIAMS: News: Skin manifestations in VEXAS syndrome are common and provide an important early clue to the diagnosis of this life-thr….
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RT @SophieGeorgin: A look back at the first workshop on #VEXAS syndrome! > 100 participants from 19 countries came in Paris. Thanks to the….
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Many thanks to our French colleagues for hosting the first international VEXAS Congress in Paris. The only thing that was better than the science was the friendship. We had the best time with you! @SophieGeorgin @TerrierBen @mekinian2 @bhavishap29 @emmamgroarke @maferradastrong.
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RT @AlexBickMDPhD: UBA1 somatic mutations of indeterminate potential? our provocative finding in @AllofUsResearch led by @rheumrob with @….
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Population databases have shown very different findings related to VEXAS, reflecting selection bias. In AllofUs, 74 people with VEXAS mutations, 62 of them were female, 100% were p.Met41Leu, unclear if they have any disease phenotype. Terrific work led by @rheumrob !!!.
Somatic mutations in UBA1 cause VEXAS, a severe inflammatory syndrome. For the first time, researchers have found 74 people with the mutation who don't have VEXAS. Studying them may give a peek into the earliest phases of disease. In A&R.@rheumrob
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Looks like CH is more a marker of inflammaging that primary driver of vasculitis - but may modify disease course.
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We looked at CH prevalence in three forms of vasculitis that span the age spectrum. Found that: .1. Age stronger driver of CH than vasculitis .2. Mostly small clones in DNMT3A and TET2.3. Association of clone size and relapse in GCA (unclear direction of association).
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Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu’s arteritis, ANCA-associated vasculitis and giant cell arteritis New collaborative work from rheum and heme at NIH @fergutierrezro1 @bhavishap29 @KQuinnRheum @NealSYoung1.
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#ACR23 need to find better way to incentivize attendance on the last half day of ACR Convergence. Turnout again pretty abysmal. Not fair to presenters of some very nice work today. End on full day or do something big at the very end.
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RT @emmamgroarke: Everyone at #ACR23 be sure and tune in to @AtefehGho’s talk this Wed showcasing our @nih_nhlbi @MayoClinic @NIH_NIAMS col….
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First ever non-HLA germline genetic association identified in RP. Masters thesis work from Yiming Luo from our group at NIH. @RP_Organization @maferradastrong . Ultra-rare genetic variation in relapsing polychondritis: a whole-exome sequencing study
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RT @AlexBickMDPhD: #ACR23 check out @rheumrob's late breaking poster tomorrow - he has identified individuals with somatic UBA1 mutations w….
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RT @drdavidliew: @maferradastrong is an inspiration. She was driven to improve outcomes for relapsing polychondritis, the disease she live….
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Family talking this morning about the “speaker of the house” being removed. Five year old looked concerned and nervously asked, “Alexa?” 🤣🤣🤣.
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RT @drlalonares: 👆🏼#VEXAS syndrome is believed to only affect individuals above the age of 50. 😮We describe an early-onset case in a 23 y/….
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Best part of the VEXAS project from the science perspective is the collaborations! Rheum + Heme is an amazing confluence of interests.
Excited to share our work on CH in #VEXAS syndrome in collaboration with amazing colleagues at @MayoClinic .Full article - .@nih_nhlbi .@fergutierrezro1 @MrinalPatnaik @petercgrayson @NealSYoung1
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