RT @mikhailspivakov: Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors rec….

credits: @QingdaoU, @KCL_OAP, @KingsIoPPN , @MRC_LMS , and of course the inimitable @mikhailspivakov.

Our discovery shows how the brain quickly pivots to "self-preservation mode" as soon as stroke happens. What we want to find out next is - how can we enhance this capability to protect the brain from stroke damage?.

We find that within 1 hour of stroke, the brain begins to reorganise its network by fine-tuning synapses - the communication points. While synapses in the stroke-affected areas shut down to preserve energy, synapses on the other side of the brain step up to compensate.

. The first few hours of stroke make the difference between disability, life, and death. What are the built-in mechanisms protecting the brain? I's not quite clear, and it's difficult to develop new treatments without knowing these mechanisms.

RT @wartranslated: I’m not sure if this is some sort of handbook or just the schizophrenic musings of this blog’s admin, but this Russian c….

Basically, it looks like a little bit of body heat can go a long way towards getting stuff places. Therefore, every NHS hospital should have a sauna or a gym or a year-round excessively sunny beer garden. Or just the latter, to save taxpayers' money.

This is kind of neat, because sometimes we really want an antibody to get into the brain, e.g. if this antibody is a expensive fancy drug against Alzheimer's.or an expensive fancy drug against brain cancer.or an inexpensive no-so-fancy drug against cancer metastases in the brain.

Basically, we show that temperatures equivalent to ordinary fever or hyperthermia can induce membrane trafficking in various tissues. This in turn may allow an antibody to get from the bloodstream into the brain, which normally doesn't really happen.

a cup of Lemsip nestled between your limp clammy hands. And you may ask yourself "How do I work this?". CHORUS.Membrane trafficking (repeat 36 times, fade out).

VERSE.You may find yourself staggering off a sweat-drenched treadmill. You may find yourself hatless jolted back awake on a Mediterranean beach. You may find yourself languishing on a sofa under a blanket. staring blankly at some Netflix dross.

RT @alphabeata_: On my way home from an incredible week at the Biophysical Society Molecular Biophysics of Membranes conference, where I pr….

Not sure if HBO will want me to take down that still, but here's for those of you who never had the makings of a varsity athlete.

This project took 3 years to complete, necessitated a collaboration spanning 4 countries, and was led by a Masters medical student. Shout-out to @CrowdfightTeam for hooking me up with some quality people!.

Ta-da! Behold my paper describing a new mechanism for action of (almost) all antidepressants. It's membrane trafficking, and it can bring stuff into the brain. Now, can this help bring new fancy Alzheimer's drugs into the brain?. <TBC, subject to £££>.

RT @maria_avdv: Russian occupiers facing a streak of bad luck today. First Novoozerne, now surprise explosions around Kerch. Guess those wa….

RT @ewers_helge: New on BioRxiv: Adhesion energy controls lipid-binding mediated endocytosis. A group effort lead by @RaluucaG with contrib….

RT @NIHRMaudsleyBRC: New research @BMCMedicine, led by Dr @olegglebov1 @KingsIoPPN, shows that #mentalhealth patients who were prescribed a….

RT @KingsIoPPN: New research @BMCMedicine, led by Dr @olegglebov1, shows that #mentalhealth patients who were prescribed #antidepressants w….