Thank you @ashleevance for posting this great summary of our work at @newlimit to radically extend human healthspan Visit the careers page on our website (link in follow on post) to join us on this mission

.@newlimit has raised an additional $45M from new investors including Lilly Ventures, Duke University, @S32_VC, @AbstractVC & others. Insiders including @kleinerperkins, @_DimensionCap, @humancapital, @BoostVC also participated. This round was catalyzed by technical

through the late summer @newlimit, we've been upgrading our 1st prototype medicines to prepare for human trials highlights - +2 prototype medicines with efficacy in liver disease models - +14 TF payloads that restore function in old T cells - +4000 TF sets tested across

"A good way to understand a lot of evolution—and how you're able adapt to new environments or pathogens—is that gene duplication is possible. The real problem is this: if one or two mutations break the gene, and only three mutations together fixes it again, it’s very hard for

.@dwarkesh_sp has a rare talent for traversing the tree of ideas by stepping upon only the most entropic branches it was a joy to discuss ideas around AI in bio, human evolution, the biology of aging, @newlimit, & the future of therapeutics a few weeks back

.@jacobkimmel thinks he can find the transcription factors necessary to reverse aging. 0:00:00 – Three reasons evolution didn't optimize for longevity 0:12:48 – Why didn't humans evolve their own antibiotics? 0:26:08 – De-aging cells via epigenetic reprogramming 0:45:24 – Viral

improving biology that evolution has optimized is absurdly difficult. one reason for optimism in longevity is that evolution hardly selected for it. even simple interventions can restore function or extend life. it seems likely that medicines turning on just a few key genes can

You will definitely want to tune into this pod with my cofounder @jacobkimmel and my favorite podcaster @dwarkesh_sp. Jacob has this rare combination of being super deep in bio and ML (he’s often technically more adept than candidates we interview for nearly every role @newlimit)

https://t.co/1C726mKfWv

great overview of @_DimensionCap portco @newlimit, pioneering tech in epigenetic reprogramming to ̶s̶l̶o̶w̶ reverse aging in pursuit of future life saving, life extending, medicines

ashlee & the @corememory team are among the best storytellers in science. we were privileged to host them for a look inside @newlimit. we hope this is only the first of many windows into our mission to add healthy years to each life.

NewLimit paper just dropped @icmlconf showing our SOTA AI models can predict perturbed cell states. Helps to have the largest primary cell perturbation dataset in the world. Bonus points for one of the first demonstration of active learning in bio.

reprogramming cells with transcription factors is our most expressive tool for engineering cell state traditionally, we found TFs by ~guesswork @icmlconf we're sharing @newlimit's SOTA AI models that can design reprogramming payloads by building on molecular foundation models

The research @newlimit over the last quarter has moved my probability that Aging is reversible to 90% and that anti-Aging Medicines will exist to 70%. Still a lot of work to do! That age is a ~plastic state continues to be the secret that the team @newlimit believes while ~the

Important updates from @newlimit on our progress toward curing aging (or at least restoring function that your cells had when you were younger). This is one of the most important and ambitious projects to benefit humanity. Visit the NewLimit careers page on our website to work

RT @jacobkimmel: this summer @newlimit, we built our first prototype medicine that restores multiple youthful functions in old hepatocytes.…

https://t.co/06TKpkM2Zw

Check out this interview with our Head of Ops Cathy O'Hare and @EleanorSheekey (link in follow on post)

𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐍𝐞𝐰𝐬: @newlimit raised a $130M series B round last week to advance its work using epigenetic reprogramming to improve cell function and thus aim to extend longevity. Full video: https://t.co/yaVLnuGUDc

Congrats to the entire team at @NewLimit, led by @jacobkimmel, Cathy O'Hare, and @byersblake who deserve the credit for making this milestone possible! Exciting progress, and lots to build.