📢 Happy and excited to share our latest research article, out now in @ScienceAdvances .Gene regulatory landscape of cerebral cortex folding | Thanks to all members of @LabTiwari & @BorrellLab, @LdelValleAnton for their amazing contributions on this. 1/.

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Our findings highlight precise & dynamic gene regulation mechanisms, essential for normal cortical formation. Conserved role of Cux2 across species suggests its fundamental importance in brain development & its evolutionary significance.8/8.Full article👇.

We found that Cux2 controls radial glia cell (RGC) fate, neurogenesis, and neuron maturation. Cux2-overexpression reduced - the immature RGCs & production of intermediate progenitors, while inducing a more committed RGC type to proliferate and undergo Direct Neurogenesis!.7/

We then questioned which cell type transcriptional alterations underly the Cux2 driven cortical folding program & performed single cell transcriptome analysis on FAC-sorted Cux2-overexpressing cells from the developing ferret cortex!!.6/

We then studied Embryonic Overexpression of Cux2 in both ferrets and mice, which led to significant changes in their brain folding patterns!!.Caused additional folding in ferret cortex. Induced folding in otherwise flat mouse cortex. 5/

We identified that Cux2 is differentially expressed & Cux2 motifs are differentially enriched between cortical regions that later on emerge as folds(gyri) vs grooves (sulci), regulating its downstream targets & thereby essential signalling pathways during cortical development. 4/

🧠 We utilized Ferret as our experimental model due to their highly analogous cortical folding patterns to humans, making them ideal for our investigation. 🧬We employed spatiotempopral transcriptomic and epigenetic analysis approach to identify several transcription factors. 3/

What we did? Investigated the regulatory factors shaping the cerebral cortex.Why? Cortical malformations->neurodevelopmental disorders.Found something? Yes! Blueprint for brain folds or protomap, established during embryonic development, even before the physical folds appear!!.2/.

RT @BorrellLab: Gene regulatory landscape of cerebral cortex folding | Science Advances

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RT @BorrellLab: Multiple parallel cell lineages in the developing mammalian cerebral cortex | Science Advances

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Thanks @tangming2005 for sharing your knowledge & helping with your computational posts! @TuncayBaubec (thank you) kindly suggested me to look for crazyhottommy when I first ventured into genomics to learn ChIP-seq data analysis and I was surprised too: if the name is for real!.

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