
Norman Sharpless
@nes047
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Jupiter BioVentures and UNC SOM; former NCI and FDA employee. This is my personal account. COI: Jupiter, G1 Therapeutics, Karius, Nucleus, ACS
Chapel Hill, NC
Joined October 2012
This article from @KFFHealthNews is disinformation. It’s an insult to readers seeking honest reporting about NIH and misleads prospective patients who may need lifesaving care at @NIHClinicalCntr. Inpatient admissions at hospitals nationwide are in a long-term decline. But there
NIH documents viewed by @rachanadpradhan show a pronounced decline in patients at the 200-bed NIH hospital from February through April, after the Trump administration began mass firings of federal workers and its broad crackdown on immigration. https://t.co/RP172j3SM0
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🤠 👉🏽 🗽 news: I will be joining @nyulangone on September 1, 2025 as Director of the GI Cancer Center & Associate Director of Translational Research at @Perlmutter_CC. I am excited to start the next chapter of the Maitra Lab in NYC & build a strong GI cancer research program.
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🧵 Twenty-five years ago, it was common to hear complaints about a “drug lag”—the perception that Europeans routinely enjoyed medical advances years before their American counterparts. Through a generation of congressional actions, investments in expertise and hiring, and careful
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How the @NIH dominates the world’s health research — in charts. Great comments by @MiriamMerad
nature.com
Nature - Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.
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Nearly 100 NIH study sections were canceled in the past month. Here is a list of the canceled meetings, compiled by Annika Barber at Rutgers Univ. As a result, the process of biomedical science funding has been halted in the United States. https://t.co/64wz2HUUYc
docs.google.com
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So what's happening with medical research in the US? This is the cumulative award count from the NIH for the year. Doesn't look so good. But it gets worse. 1/
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Time to re-up this. Congrats to Larry T on a great career at NIH. A wonderful Fed.
This is great news for @NIH and it’s about time. But two things: 1. who is gonna run @theNCI now? and 2. Let’s all take a moment to thank Larry Tabak for doing terrific job as Acting @NIHDirector for a long time over a difficult period. 👏🏽👏🏽👏🏽
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If we want to thoughtfully reduce NIH indirect costs, we need to reduce the federal regulatory burden that causes universities to hire so many administrators to remain compliant.
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Every year, ~90,000 teens and young adults receive a cancer diagnosis. Programs like those at @UNC_Lineberger—an NCI-Designated Comprehensive Cancer Center—help young people navigate treatment, enroll in trials, and get fertility counseling. Read more:
cancer.gov
A program at an NCI-Designated Cancer Center has had success at increasing the number of adolescents and young adults with cancer who get recommended care.
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Novocure and its Tumor Treating Fields (TTF) Modality meets its Phase 3 trial primary endpoint of improving survival in local advanced #PancreaticCancer (LAPC). Caveats are several: - modest improvement in survival (one of those statistically significant but “is it meaningful”
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A single-cell atlas of aging tissue demonstrates shared multi-omics of aging and cancer hallmarks https://t.co/DgBcpvYegc
@NatureAging @jacksonlab @justsaysinmice @OlgaAnczukow
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The rise of industry-sponsored cancer clinical trial enrollment from 2008 to 2022, now surpassing NIH-sponsored trials, highlights a shift in oncology research priorities. This trend may limit opportunities for addressing broader, patient-centered questions that are not
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@PTarantinoMD @YAbdouMD @JCO_ASCO A link to the editorial by @YAbdouMD @nes047 @UNC_Lineberger
https://t.co/dEn58AEHhF worth reading!
ascopubs.org
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Out in JCO: the ratio of enrollment to Industry- vs Federally-sponsored trials doubled between 2008-2022. This led to an acceleration in drug development, but less trials exploring de-escalation or non-drug-related questions. Great editorial by @YAbdouMD. https://t.co/xEAndVHDrg
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An important study by F. Eun-Hyung Lee's team shows that long lived plasma cells (the source of long-term circulating antibodies) fail to establish after mRNA vaccination (even combined with SARS-CoV-2 infection). 🧵 (1/) https://t.co/Z15xiyxCLS
nature.com
Nature Medicine - The rapid waning of SARS-CoV-2-specific serum antibodies observed after immunization with COVID-19 mRNA vaccines may be accounted for by the absence of long-lived plasma cells in...
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I'm excited to announce that @NCICCHE Director Dr. Sanya Springfield will be an acting deputy director at @theNCI – in this new role, she'll be charged with broadening and strengthening our cancer health equity and inclusion efforts. #EndingCancerAsWeKnowIt for all.
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I'm honored to present #SCLC updates at the 2nd annual Thomas C. Shea Clinical Cancer Symposium on Monday, September 23rd from the @UNC_Lineberger cancer center alongside Drs. @DrJaredWeiss @JulieBrahmer Mark Socinski @nes047 and others! In person @The_Umstead in Cary, NC!
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Leading the @AmericanCancer Society + @ACSCAN is the honor of a lifetime. Over the last 3.5 years, we increased our impact and focused on improving the lives of cancer patients. I love this org! With ACS on strong footing and having accomplished what I came to achieve, today I
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So sad to hear about the passing of Jeff Weber, a giant in the field of oncology. He was involved in the early days of cytokine and cell therapy and most recently led studies of personalized vaccines for melanoma patients. I originally worked with Jeff @theNCI over 30 years ago.
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Vir Biotechnology announced today it's all but abandoning infectious disease research and pivoting to cancer. My story from May on how a grand, billion-dollar plan to build a company to create "a world without infectious disease" fell apart: https://t.co/jboFQYyWFQ
statnews.com
In 2017, Vir Biotechnology's founders threw millions at infectious disease. Covid made them look like geniuses. The road since then has been far rockier.
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