Nenad Pavin
@nenad_pavin
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Joined July 2017
Amazing energy at our second Swiss-Croatian Bilateral Project meeting with @LabMeraldi and @nenad_pavin in Srebreno near Dubrovnik! The labs teamed up instantly, with lots of brainstorming and cool ideas for new joint projects! @hrzz_science @snsf_ch 🇭🇷🇨🇭
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🚀Ever wondered if there's a universal rule of spindle scaling across eukaryotes? Turns out, there is! Our study reveals an evolutionarily conserved principle driven by a surprising factor: chromosome crowding. 🧵👇 https://t.co/TUixBEHYQF
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🎉 Congrats to @LovroGudlin, @KrunoVuk, and Maja for the awesome work! This was a super fun collaboration with @nenad_pavin, including our ERC Synergy team @ERC_Research - Geert Kops and MIT. Special thanks to @ZStorchova and our mathematicians, Josip Tambača and Matko Ljulj!
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Our approach also reveals that stable points can exist in the vicinity of spindle poles, in addition to the one in the center, and thus provides an explanation for erroneous spindles with polar chromosomes.
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Passive cross-linkers produce forces that pull the chromosomes toward the closer pole, opposing congression. However, for longer microtubules this force changes its direction.
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The basic idea of the centering mechanism arises from a length-dependent force, where longer microtubules accumulate a greater number of motor proteins. Our calculations show that chromosomes approach the central plane in time relevant for healthy cells.
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The well-coordinated movement of chromosomes from the cell’s periphery to its center—a critical aspect of cell division—can be driven by length-dependent pulling forces generated by motor proteins and passive crosslinkers, as shown in this study.
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Excited to share our latest study on mechanisms of chromosome positioning during mitosis. Congrats to @sigmund_ivan, @BozanDomagoj and Ivana on work published in @PRX_Life. https://t.co/btgxlFzRGC
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Excited to share our latest work, just published in @PNASNews and led by @risteski_! Check out the highlights in the thread below, and the full text here: https://t.co/DXCJYcTAwZ
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This work was done by Ivan Sigmund, Nenad Pavin (@nenad_pavin), and their colleagues at University of Zagreb and @institutrb.
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New EMBO Members James Liao, Arnaud Echard @TMDCLab_Pasteur, Elif Nur Firat-Karalar @CytoLabKoc, Philippe Pasero @PaseroLab, Nenad Pavin @nenad_pavin, Monica Gotta (not on the photo), Yardena Samuels @Samuels_lab, Gou Young Koh @gou_koh. Welcome to the EMBO Membership! #EMBOat60
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#TalentsCNRS🥈 | Renata Basto, lauréate de la médaille d’argent du @CNRS pour ses recherches sur le centrosome. À l'@institut_curie, elle étudie les variations du nombre de centrosomes et chromosomes et leur implication dans les cancers. ▶️ https://t.co/OV4HxwWKUa
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I’m beyond thrilled to be selected for @CRUKresearch's new Bridge to Academic Leadership programme, which will support the next generation of cancer research leaders and guide postdocs toward independent group leader positions. 😃😃 https://t.co/cNEgnuDRgO
cancerresearchuk.org
Our bridge to academic leadership programme supports postdocs in their transition to an independent group leader position.
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New paper in the lab from out postdoc @AlexT_biology !
Human culture cells don’t always divide symmetrically. @AlexT_biology and Meraldi @LabMeraldi @unige_en reveal that centrosome age can lead to unevenly sized spindles. This unexpected asymmetry results in daughter cells of different sizes via kinase Plk1. https://t.co/Vy318nKTl7
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Big congrats and welcome to all the new members! I'm especially excited to see @nenad_pavin and Ita Gruic-Sovulj from our neighboring institution @PMFZAGREB join the @EMBO community!
Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community https://t.co/eHCoXY0ynR
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Thrilled to share that I've been elected as a member of @EMBO! I'm honored to join this community of leading scientists driving excellence in the life sciences. Thanks to my amazing collaborators for their support and partnership. https://t.co/yFZcTufmK6
Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community https://t.co/eHCoXY0ynR
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Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community https://t.co/eHCoXY0ynR
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Two and a half days in Split full of exciting discussions about centrosomes, polar chromosomes, and poleward flux at the kick-off meeting of our SNSF-HRZZ @snsf_ch @hrzz_science project! Thanks to the whole team @LabMeraldi @nenad_pavin @Toliclab for the fantastic atmosphere!
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Hey there, the super exciting EMBO | EMBL Symposium: "The mechanics of life: from development to disease" is approaching! Submit your abstract by Jan 22, and see you in Heidelberg. #EESMechanobiology
https://t.co/GCA5mqzqtl
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