Nastassia Knödlseder
@NastassiaKn
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Joined April 2023
New Preprint!! @alex_gonzadel accomplished a major feat on this one: ported retron recombineering, which we love so much in E. coli, into 14 new bacterial species via a massive collaborative effort involving 9 labs! https://t.co/EtUEe3ZYvk
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🚀 Great news for our lab! We’ve received a €2.5M EIC Transition Grant to advance #Synflora, an innovative biotech treatment for acne. By engineering skin bacteria to release beneficial molecules, we aim to revolutionize dermatology! 🔬✨
upf.edu
Synflora ha obtingut l’ajut EIC Transition per impulsar una solució biotecnològica que modifica genèticament els bacteris de la pell per alliberar molècules beneficioses que permetin combatre...
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An engineered commensal bacterium delivers brain-targeted therapeutics via intranasal administration in mice. https://t.co/QR9zJBBizR
#NBThighlight
cell.com
Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic...
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💡What if bacteria on your skin could be reprogrammed to improve skin health?💡 For scientist @NastassiaKn synthetic biology isn’t just about research – it’s about solving real problems at a microscopic level to improve lives. Read full interview here: https://t.co/dY1FtUeLPJ
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Thank you @UPFbiomed for this recognition!
Our PhD @NastassiaKn received the extraordinary doctoral award for her wonderful doctoral thesis on skin microbiome from the pompeu fabra university, congratulations Nastassia😊
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Our second book is now available for pre-order. 🎉 Embracing the book's technology theme, we did something special: We encoded the entire book into DNA & packaged it into stainless steel capsules, where it will live for tens of thousands of years. 1,000 copies were made... 🧵
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Can degraded ecosystems facing tipping points be rescued using synthetic biology? In our new paper with @VictorVmaull we show how a new class of "emergent engineering" can do it by havig biodiversity on our side https://t.co/rDmQhHDp5B
@ftmaestre @vdlorenzo_CNB @BlaiVidiella
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🎓 Eight doctoral students from the PhD Programme in #Biomedicine will receive the @UPFBarcelona Doctoral School PhD Extraordinary Award Congratulations to you all! 👏🏽💐💫 Have a look at their projects following this thread 👇🏽 👉🏽 https://t.co/YrdR288YOr
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Allying with skin bacteria to treat pathologies 🦠💊 In this short video, researcher @NastassiaKn explains the latest advances in the @UPFbiomed Translational Synthetic Biology Laboratory in the creation of living pills. https://t.co/JKvm5yf5ru
instagram.com
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Lovelock-Margulis ideas on the Earth as a self-regulating system can be tested, and we discuss it in our latest paper: A Synthetic Microbial Daisyworld. @jordiplam, N. Conde @ricard_sole @RSocPublishing
https://t.co/9uny6fXUim
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Interesting approach for acne treatment: engineer bacteria to work like Accutane, but locally (and without all the nasty side effects)! Modified C. Acnes bacteria secrete NGAL to kill sebocytes & thus sebum production. They engraft on mice skin & produce NGAL there.
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@marcguellc @NastassiaKn @Synbio_Lab_UPF @UPFbiomed @idibell_cat @UniBarcelona @CRGenomica @icreacommunity @lunduniversity @AarhusUni_int Smart skin bacteria are able to secrete and produce molecules to treat acne #NBTintheNews via @UPFBarcelona
https://t.co/ywqG0pufEo
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Today, we are excited to share with you our most recent work in @NatureBiotech about domesticating C. acnes, a skin microbe, as a production and delivery shuttle for therapy. Want to know more?🪡🧵
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Unbelievably happy to share our most recent publication in #NatureBiotechnology, where we show the the use of an engineered skin microbe (Cutibacterium acnes) as a potential therapy against acne vulgaris. Hope you enjoy the read:
nature.com
Nature Biotechnology - An engineered skin microbe produces a therapeutic molecule that reduces sebum in mice.
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🦠🧬Smart skin bacteria are able to secrete and produce molecules to treat acne New research by @Synbio_Lab_UPF with @NastassiaKn and @marcguellc manages to edit the genome of Cutibacterium acnes to secrete and produce the NGAL protein to treat acne. 👉🏽 https://t.co/gKNuX6Czgp
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