M P Reeve
@mpreeve
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Genetic analysis, software, photography.
Joined August 2014
Following great presentation from @nikolosov on @FinnGen_FI PGS browser, two exciting reviewer's choice posters to be presented by the lab today and tomorrow at #ASHG24 . Stop by to see exciting work by @dmitrij22981 and @ivan_molotkov_
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"Lines of Descent - Data visualisation tools to empower genetic research" exhibition showcases @AaltoUniversity's data visualisation tools developed in collaboration with FinnGen. Welcome! đąCentral Libary Oodi, Kuutio, Helsinki đ
2.-27.10.2024 https://t.co/KsR4aBEwyB
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This study was made possible by the deep phenotypic data in FinnGen tldr here:
Do oral and non-oral lichen planus share the same genetics? Yes (20) and no (7)! Our new paper @AJHGNews using @FinnGen_FI reveals genetic heterogeneity between the two, with differential risk for autoimmune diseases and oral cancer https://t.co/ohxA0h7Y1S. 1/7
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Very excited to have our work on lichen planus recognized for the @FinnGen_FI BioFinland prize together with @Aoxing2 âs work on X chromosome loss!
This year, the FinnGen publication prize goes to: đ@mpreeve for her Am J Hum Genet publication & đ@Aoxing2 for her Nature publication Warm congratulations! The prize is awarded thanks to the BioFinland Award granted to FinnGen in 2019 by the Finnish Bioindustries.
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Tervetuloa Oodi-kirjaston Maijansaliin 9.10.2024 klo 18:00 kuulemaan @helsinkiuni @FIMM_UH geenitutkijoiden tietoiskuja siitĂ€, mitĂ€ geenimme kertovat lĂ€hihistoriasta ja terveydestĂ€. Yleisöluennon tarkempi ohjelma âŹïž https://t.co/MtmyMyoQOH
finngen.fi
Tervetuloa Oodi-kirjaston Maijansaliin 9.10.2024 kuulemaan Helsingin yliopiston geenitutkijoiden tietoiskuja siitÀ, mitÀ geenimme kertovat lÀhihistoriasta ja terveydestÀ!
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1/8 âïžDid you know that the circadian rhythm in our body not only guides sleep but also regulates metabolism? We wanted to test how and when, so we used a genome-wide association study to find genes that regulate timing of glucose during the day. https://t.co/0vqCrpXjzv
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Check out the paper by @Aoxing2 on mosaic loss of X! Associations that predispose to loss of X include variants at FBXO10, and of course my favorite locus - HLA
New out in Nature!! With age, women can lose one X chromosome in their leukocytes. Whatâs the cause/consequence? How does it differ from the loss of the Y chromosome in men? https://t.co/nRw2OiNoX4
@broadinstitute @FinnGen_FI @FIMM_UH @theNCI @Cambridge_Uni
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Interested in doing a post doc in #sleep in the Nordics - Finland or Estonia in particular? Opportunity to work on big data, genetics, infections and their outcomes. Looking for ambitious and nice people! We collaborate with amazing people @jlane_boston @GenomicsDoge
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@AJHGNews @FinnGen_FI Big thanks to @CellPressNews - we started at Cell Community Review and had a smooth publication experience from start to finish! Great collab with @samrip, @nikart89, @dalygene, @HannaMOllila, S Luo, M Vehvilainen, M Siponen, Nicola Cerioli and Federico Simeoni and all authors!
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@AJHGNews @FinnGen_FI This is also the debut of our new FinnGen tool MultipleManhattanPlot (MMP) for visually comparing GWAS results across traits, you can try it out from: https://t.co/74sUaWhm48 (UI) and https://t.co/BjQTFRqbPq (sumstats munging code). 6/7
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@AJHGNews @FinnGen_FI Beyond the HLA link to autoimmunity, top non-HLA LP hits (TNFSF11, CEP43, LPP, C12orf42, IFIH1) are shared with other autoimmune diseases. Across the cohort, oral and non-oral LP show different associations with autoimmune diseases, skin conditions, and oral cancer. 5/7
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@AJHGNews @FinnGen_FI On the other hand, oral LP shows a 14x increased risk for tongue cancer and a stronger association with IFIH1, CASP8, CEP43, GRAF2, C12orf42, and ZFP36L1.
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@AJHGNews @FinnGen_FI Non-oral LP shows a significantly greater effect at HLA DQB1*05:01 + an association near CLEC16A that does not reach nominal significance in oral LP, making it look more autoimmune. Intriguingly, CLEC16A is also adjacent to CIITA, a master regulator of MHCII transcription.
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@AJHGNews @FinnGen_FI ICD10 codes for lichen planus do not specify body location, but using lifelong records in @FinnGen_FI covering dxs, procedures (e.g. biopsy locations), and especially clinic type, we were able to carefully construct subcategories of oral LP (n=3,323) and non-oral LP (n=4,356) 2/7
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Do oral and non-oral lichen planus share the same genetics? Yes (20) and no (7)! Our new paper @AJHGNews using @FinnGen_FI reveals genetic heterogeneity between the two, with differential risk for autoimmune diseases and oral cancer https://t.co/ohxA0h7Y1S. 1/7
cell.com
The relationship of oral and skin forms of lichen planus (LP) is not understood. Using GWASs in two biobanks, we identify 27 independent hits, which include shared and distinct genetic features...
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A bright and shining example of the suicidal absurdity of technocapitalist society occurs every year at this time, all across the country. 1/n
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We are happy to announce release of FinnGen-UKBB meta-analysis results for 679 phenotypes at: https://t.co/YYWjocgmGp - enjoy browsing and downloading! #genomics #OpenScience
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Preprint out! Meta-analysis of Idiopathic Pulmonary Fibrosis (IPF) genetics with a 4-fold increase in the number of patients identifies 7 novel associations in 6 populations from 13 biobanks around the globe 1/4 @jukka_koskela @dalygene
https://t.co/S25xjIdzEA
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