@ibdleuven @bverstockt @NickPowellLab @modoslab @johanne_brooks @ImperialMDR We were honored to get an Editorial at the journal highlighting our study and its implications. We are grateful for the great Claudio Fiocchi and Dimitrios Iliopoulos for their insightful summary. https://t.co/nUEb76y8a5

Our findings show how genetic variation reshapes cellular signaling in #IBD (see two patient-specific networks 👇), providing a foundation for #PersonalizedMedicine. Collaborative work with @ibdleuven @bverstockt @NickPowellLab @modoslab @johanne_brooks 🙌 From @ImperialMDR

👀 check out projects 1 & 6 on the list: 1️⃣ Multicellular molecular characterisation of inflammatory bowel disease 6️⃣ Designing Efficient Single-Cell Perturbation Experiments with Lab-in-the-Loop AI Agents 📅 Application deadline is 30th September ❗

🎉 The revised version of CORNETO, our unified Python framework for knowledge-driven network inference from omics data, is published in peer reviewed form 🔗 Paper: https://t.co/l2UH0ae9jA 📖 News & Views: https://t.co/0mouNBKXic 💻 Code: https://t.co/DdyOYKh1u9 🧵 Thread 👇

Great to see this work from Shiv Radhakrishnan and colleagues out in #GutMicrobes - using network analysis to explore #microbiome #metabolome interactions in an #IBD inception cohort: https://t.co/U5xRhFgVzM @IHepatology @ImperialMDR @KorcsmarosLab

Inspiring few days on how to identify mechanisms for #MyalgicEncephalomyelitis (ME) / Chronic Fatigue Syndrome. #SystemsBiology session w/ @modoslab #Cytokines w/ @martonolbei #organoids & new #Gutonchip + #microbiome platforms @ImpOrganoid @ImperialMDR Thanks for @Invest_in_ME

"I often wonder… Why isn’t this therapy working for my IBD patient?" Then I remind myself: It could be… ❗ Too Late – Delayed start of effective therapy ❌ Wrong Choice – Misaligned mechanism of action or incorrect diagnosis 💊 Not Taking Medication – Non-adherence is real ⬇️

I have a talk out at YouTube which was held at the @PMC_modularity community. If you are interested in #networkbiology and #ibd than maybe worth a check next to some coffee or some boring tasks. https://t.co/as3iynD3NW

🚀 The Interdisciplinary Signaling Workshop 2025 is taking shape! 🔬✨ A unique multidisciplinary program connecting #ECR & #PhD students with world-leading experts in #IBD, #microbiome, #organoids, & #PrecisionMedicine Details & registration by 4 April: https://t.co/R3g5tBODNm

I’m organizing another Signaling Workshop this July for #PhDs #ECRs & @Y_ECCO_IBD! ✅ Interdisciplinary: #IBD, #cancer, #microbiome, #organoids, #multiomics ✅ Networking: Leading experts from diverse fields ✅ Group projects 🔗 https://t.co/R3g5tBODNm Check video from 2023👇

Of course you can take the other approach telling a neural network to parametrise the system for itself, but you (1) need a lots of data (2) you need to avoid overfitting. Well it is just a quick thoughts after a great event. Anyone here, any thoughts? 4/4

but still in a cell a million other possibilities are present for regulation (local concentrations, intra cellular location constraints, degradation times at all levels). It is almost impossible to include everything without overparametrising the model. 3/4

Meanwhile hundreds of proteins. How can we choose the right interactors, the right context? I usally use only some transcriptomic data to contextualise the network and using only those proteins whose transcripts at least measuarable in trace. I exclude the impossible, 3/4

It was fantastic to talk today at the Protein Modules Community event. Dr Joanna Koszela's work reminded me how important is to contextualise the network. She worked on Parkin, an E3 ubiquitin ligase, and she showed amazingly the target preference. 1/4

Looking forward to another great course!

Your work can inspire the future of bioinformatics. Submit your abstract for ISMB/ECCB 2025 and present your research as an oral or poster presentation.

Very proud of our clinical PhD fellow, John Thomas @MRC_LMS to win the Top15 best talk award #ECCO2025 - from >1000 abstracts/~200 talks 👏 He showed how genetics can predispose to #IBD due to patient-specific environmental signal changes W/ @modoslab @NickPowellLab @ibdleuven 🙌

Excited to share our work on UC cytokine networks at #ECCO2025. Come by poster P0104 if you are interested in: - how cytokines regulate each other in UC - the role of TL1A in treatment-naive UC - how we could use this approach to identify new drug targets

Who else will come to Liverpool?

I had a fantastic two days at the Festival of Genomics. I met old and new colleagues and friends, learned about AI in drug discovery and microbiota in cancer. Also had a photo with Darth Vader. #FOG2025