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Maiato Lab Profile
Maiato Lab

@mitosisrocks

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News from the Maiato lab, studying Chromosome Instability and Dynamics @i3S_UPorto.

i3S, University of Porto, Portugal
Joined March 2018
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@mitosisrocks
Maiato Lab
3 years
Very happy to present @lopesdanilo11 PhD work out now in JCB! He went the extra mile to characterize the #CancerTubulinCode in the NCI-60 cancer cell panel. To read more about how Tubulin detyrosination links MCAK activity with Taxol cytotoxicity go to
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@mitosisrocks
Maiato Lab
3 years
Also check out posters by @Jor_Ferreir (P2003; B323) today from 12:15-13:45 pm and @vanessacrnunes (P2569; B176) Tuesday 6th from 1:45-3:15 pm. They will be talking about mechanical cues acting on the nucleus to regulate the G2/M transition.
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@mitosisrocks
Maiato Lab
3 years
Hey mitosis folks! CID lab will be represented at #ASCB2022 by PhD student Hugo Girão. If you are interested in the role of tubulin tyrosination status in mitosis stop by his Poster (P1848; B158) today from 1:45-3:15 pm! (Microtubule Dynamics Session) #cellbio2022 #TubulinCode.
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@mitosisrocks
Maiato Lab
3 years
RT @biorxivpreprint: #PeerReview from @ReviewCommons of 👉🏿 Long-term mitotic DNA damage promotes chromokinesin-mediated missegregation of p….
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@mitosisrocks
Maiato Lab
3 years
Today we celebrate one more CID lab member's accomplishment! Congratulations to Marco who successfully defended his PhD thesis on the impact of DNA damage during mitosis (read more at . It has truly been a pleasure to watch you grow as a scientist!
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@mitosisrocks
Maiato Lab
3 years
Check out our new preprint by Margarida Gomes, where we talk about an unexpected path of micronuclei formation from unaligned chromosomes: 👇.
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@mitosisrocks
Maiato Lab
4 years
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@mitosisrocks
Maiato Lab
4 years
#chromosomeseparationcheckpoint.See also independent related works by the Higgins and McAinsh labs ..
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@mitosisrocks
Maiato Lab
4 years
#chromosomeseparationcheckpoint.Our latest work showing that a midzone Aurora B activity gradient prevents micronuclei formation from frequent chromosome segregation errors that escape the surveillance of the spindle assembly checkpoint
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cell.com
Orr et al. show that a spindle midzone-based Aurora B phosphorylation gradient mediates a surveillance mechanism that prevents micronuclei formation from frequent chromosome segregation errors by...
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@mitosisrocks
Maiato Lab
4 years
RT @CaixaResearch: Un sello distintivo del cáncer son los errores en la división celular. El proyecto de la convocatoria #CaixaResearchFun….
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@mitosisrocks
Maiato Lab
4 years
And to follow yesterday's good news, both Joana M and Joana O were awarded PhD Studentships from FCT! They will be starting their projects in September, after taking a well-deserved summer break.
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@mitosisrocks
Maiato Lab
4 years
Happy to share that both Antonio and Liam had their grants funded in the latest FCT call!.
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@mitosisrocks
Maiato Lab
4 years
Very pleased to be part of this latest round of funding and very grateful to La Caixa for investing in our group. Looking forward to doing some more exciting research on microtubules!.
@CaixaResearch
CaixaResearch
4 years
¡Felicidades a los 9 proyectos sobre oncología seleccionados en la convocatoria #CaixaResearchFundlaCaixa 2021! 🎉. Liderados por investigadores de @IMMolecular @idibaps @CIMA_unav @i3S_UPorto @IBECBarcelona @CRGenomica
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@mitosisrocks
Maiato Lab
4 years
New paper from the lab! Liam (@SciencyCheese) and Helder discuss a recent study by Uchida et al. regarding the role of intra-kinetochore stretching in silencing the SAC, and where these results fit in our current understanding of kinetochore function.
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@mitosisrocks
Maiato Lab
4 years
RT @Jor_Ferreir: Great effort from @vanessacrnunes. If you want to know more about the nucleus and its role in early spindle assembly. Fro….
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@mitosisrocks
Maiato Lab
4 years
RT @AC_Almeida_: Curious about an alternative mammalian model system, and its potential to tackle k-fiber maturation? Tune at breakout room….
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@mitosisrocks
Maiato Lab
4 years
For those interested in hearing more about our latest preprint, Bernardo will be giving a short talk about it at tomorrow's Digital Cell Cycle Club! In addition, Ana will also give a talk on the role of Augmin in k-fibre maturation. Tune in at the breakout session at 4.20 pm GMT!.
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@mitosisrocks
Maiato Lab
4 years
Very happy to work with Jon's team to release these complementary studies, which both help to elucidate the function of the Aurora B gradient in anaphase.
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@mitosisrocks
Maiato Lab
4 years
This work was done in parallel with Jonathan Higgins' lab, who shows that the Aurora B activity gradient can still phosphorylate kinetochore substrates in anaphase, thereby continuing to regulate attachment stability and kinetochore function.
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biorxiv.org
Kinetochores assemble on chromosomes in mitosis to allow microtubules to attach and bring about accurate chromosome segregation. The kinases Cyclin B-Cdk1 and Aurora B are crucial for the formation...
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