🔎New preprint! We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture. Big thanks to @Ivana_Gasic and team! Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)

(5/5) Impaired adhesion is driven by changes in tubulin levels and microtubule stability. Reducing tubulin (T007-1) or mild destabilization (nocodazole) rescues the phenotype, while hyperstabilization (taxol) worsens it. 📌Tubulin homeostasis supports multicellular organization.

(4/5) How? Loss of autoregulation disrupts localization of adhesion molecules like N-Cadherin, Fibronectin, and Integrin α5: cells round up and lose anchorage. 📌Restoring adhesion (via E-Cadherin over expression or ECM) rescues tissue integrity and viability.

(3/5) Tubulin autoregulation is essential for spheroid architecture & viability. Without it: - cells detach (corona forms) - cell death increases 📌This phenotype isn’t due to cell cycle defects or migration — it reflects impaired cell adhesion.

(2/5) Loss or mutation of TTC5, the key mediator of tubulin autoregulation, increases tubulin mRNA and protein levels in 3D spheroids. This leads to microtubule hyperstability and reorganization of the network. 📌Tubulin levels matter (even in steady state!)

EMBO Fellows Meeting 2025 just wrapped up! 4 intense days, 110+ talks, amazing postdocs, mentoring & networking! Huge thanks to @embo.org & the organizers 👏 Feeling proud to be part of the next gen of scientists ready to push science forward. Sharing a few highlights 📸

Last call for abstracts 👇 Join us at the 8th PostDoc Day @sciences_UNIGE @UNIGEnews

🔬 A new probe developed by Janelia researchers & collaborators that enables visualization of extracellular matrix structure in live tissues could also be useful in studying diseases linked to changes in the extracellular matrix and in diagnostic imaging➡️ https://t.co/Z352UP70mq

This stunning image was made by @AC_Almeida_ , our brilliant President and microtubule enthusiast! She's passionate about how the cytoskeleton organizes itself in 3D—seriously cool stuff! 🧠🧵✨#Microscopy #WomenInSTEM #Cytoskeleton @MoCel_Geneva

Behold: a human cancer spheroid! This 3D cell blob models solid tumors. DAPI (blue) marks nuclei, PI lights up the dead. Z-plane colors unveil a rainbow necrotic core wrapped in a moody, monochrome outer layer. #fluorescencefriday #microscopy #postdoc

Whoa, amazing work!

Two heads, toroid shape or a mix of both are the creatures that @yamini_ravichan was able to form inducing soft compression in Hydra. GFP-Lifeact in the regenerating tissue of Hydra #fluorescenceMonday #fluorescencemonday #fluorescencefriday #microscopy #hydra

Get ready to meet the scientists behind the APDU! 🚀 Every Friday and Monday, we’ll feature one member of APDU, their work, and a stunning image from their research.🔬🌟 Tomorrow we will start with YR👀... #Postdoclife #postdoc #ScienceArt #ResearchLife

"Maybe impostor syndrome wasn’t a sign of failure, but a sign of growth." #ScienceWorkingLife. https://t.co/nnwRu9L5ls

Exciting collaboration! 🚀 Worked with Victoria from @GottaLab to test a photocaged Plk1 inhibitor in spheroids! We achieved high spatiotemporal control of cell division in specific regions within 3D multicellular systems. Check out the work! 👇

Today we had a beatiful talk of @mikhajlov_oleg in the Biology Club. We learned a lot about sguanine crystalls and their physical properties 🐟🐠. Don't miss the next Biology Club!

New paper alert! ‼️‼️ Super happy to share that my postdoc paper is finally out! We looked at scaling of chromosome separation during anaphase in zebrafish embryos.

🎉 Love morphogenesis, doughnuts, or hydra? Join us for the first Biology Club of the year! 🧬 🗓️ Today ⏰ 12:15 PM 📍 Room A100 🌟 Special talk by @yamini_ravichan: "Mechanical Induction of Morphogenesis" Don't miss it—see you there! 🙌 #BiologyClub #Hydra

Early Christmas gift! Thrilled to share the final work of my PhD journey 🙌 Check out the paper where we debate the dispensability of CENP-E for mitotic chromosome alignment in species with larger kinetochores.

𝗔𝗱𝘃𝗲𝗻𝘁 𝗖𝗮𝗹𝗲𝗻𝗱𝗮𝗿 𝟳: Define your own values and those you want to support your team to reach its goals. Then discuss these with your people. A common set of operational values provides clarity, strengthens cohesion, and improves productivity. 𝗛𝗮𝗽𝗽𝘆 𝗔𝗱𝘃𝗲𝗻𝘁: