Ana Almeida
@AC_Almeida_
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Postdoc at @Ivana_Gasic @unige. #microtubules and #microscopy lover. Cell biologist & EMBO fellow 🧬🔬Noisy Portuguese.
Genébra, Suíça
Joined March 2018
🔎New preprint! We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture. Big thanks to @Ivana_Gasic and team!.Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
biorxiv.org
Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free...
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(5/5).Impaired adhesion is driven by changes in tubulin levels and microtubule stability. Reducing tubulin (T007-1) or mild destabilization (nocodazole) rescues the phenotype, while hyperstabilization (taxol) worsens it. 📌Tubulin homeostasis supports multicellular organization.
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(4/5).How?.Loss of autoregulation disrupts localization of adhesion molecules like N-Cadherin, Fibronectin, and Integrin α5: cells round up and lose anchorage. 📌Restoring adhesion (via E-Cadherin over expression or ECM) rescues tissue integrity and viability.
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(3/5).Tubulin autoregulation is essential for spheroid architecture & viability. Without it: .- cells detach (corona forms).- cell death increases.📌This phenotype isn’t due to cell cycle defects or migration — it reflects impaired cell adhesion.
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(2/5).Loss or mutation of TTC5, the key mediator of tubulin autoregulation, increases tubulin mRNA and protein levels in 3D spheroids. This leads to microtubule hyperstability and reorganization of the network. 📌Tubulin levels matter (even in steady state!)
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EMBO Fellows Meeting 2025 just wrapped up! .4 intense days, 110+ talks, amazing postdocs, mentoring & networking! .Huge thanks to @embo.org & the organizers 👏.Feeling proud to be part of the next gen of scientists ready to push science forward. Sharing a few highlights 📸
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Last call for abstracts 👇 Join us at the 8th PostDoc Day @sciences_UNIGE @UNIGEnews.
🚨 Last week to submit abstracts for talks and posters!.Show your research, win prizes & enjoy surprises 🎉.Register here: ‘’ ‘’
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RT @HHMIJanelia: 🔬 A new probe developed by Janelia researchers & collaborators that enables visualization of extracellular matrix structur….
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RT @APDUnige: This stunning image was made by @AC_Almeida_ , our brilliant President and microtubule enthusiast! She's passionate about how….
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RT @APDUnige: Behold: a human cancer spheroid! This 3D cell blob models solid tumors. DAPI (blue) marks nuclei, PI lights up the dead. Z-pl….
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Whoa, amazing work!.
Have you ever wanted to track individual #chromosomes during #mitosis? To do live cell #karyotyping and map the inter- and intra-chromosomal contacts dynamics? Our recent work made that possible. Check out our @NatureCellBio paper:.
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RT @APDUnige: Two heads, toroid shape or a mix of both are the creatures that.@yamini_ravichan .was able to form inducing soft compression….
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RT @APDUnige: Get ready to meet the scientists behind the APDU! 🚀.Every Friday and Monday, we’ll feature one member of APDU, their work, an….
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RT @ScienceMagazine: "Maybe impostor syndrome wasn’t a sign of failure, but a sign of growth." #ScienceWorkingLife. .
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Exciting collaboration! 🚀 Worked with Victoria from @GottaLab to test a photocaged Plk1 inhibitor in spheroids! We achieved high spatiotemporal control of cell division in specific regions within 3D multicellular systems. Check out the work! 👇
nature.com
Nature Communications - Light is a powerful tool for controlling biological processes. Here, the authors demonstrate its use to modulate inhibitor activity and diffusion, enabling precise control...
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RT @APDUnige: Today we had a beatiful talk of @mikhajlov_oleg .in the Biology Club. We learned a lot about sguanine crystalls and their ph….
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RT @OlgaAfonso_: New paper alert! ‼️‼️.Super happy to share that my postdoc paper is finally out! We looked at scaling of chromosome separa….
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RT @APDUnige: 🎉 Love morphogenesis, doughnuts, or hydra? Join us for the first Biology Club of the year! 🧬.🗓️ Today.⏰ 12:15 PM.📍 Room A100….
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Early Christmas gift! Thrilled to share the final work of my PhD journey 🙌 Check out the paper where we debate the dispensability of CENP-E for mitotic chromosome alignment in species with larger kinetochores.
journals.biologists.com
Highlighted Article: Phylogenetic profiling across holocentric or monocentric metazoans, combined with functional experiments in nematodes, supports an inverse relationship between kinetochore size...
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RT @LeadSculpt: 𝗔𝗱𝘃𝗲𝗻𝘁 𝗖𝗮𝗹𝗲𝗻𝗱𝗮𝗿 𝟳: Define your own values and those you want to support your team to reach its goals. Then discuss these wi….
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