Mike Wuo
@mike_wuo
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Chemical biologist | Merck | Don't read the ingredients.
Boston, MA
Joined May 2020
RT @ChemicalBiology: @duganam, @mike_wuo, @halim_mel, and team in @ACSCentSci describe a method to rapidly screen for virus-neutralizing an….
pubs.acs.org
Enveloped viruses co-opt host glycosylation pathways to decorate their surface proteins. As viruses evolve, emerging strains can modify their glycosylation patterns to influence host interactions and...
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My boy @chaaawie with the 🔥.
To learn about phage infection and resistance in mycobacteria, we isolated resistant mutants and used microscopy to visualize the entire lytic lifecycle within single cells and in populations. Check out the video highlights below! @NatureMicrobiol
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RT @LupoliLab: Protein Cofactor Mimics Disrupt Essential Chaperone Function in Stressed Mycobacteria . Congrats to….
pubs.acs.org
Bacterial DnaK is an ATP-dependent molecular chaperone important for maintaining cellular proteostasis in concert with cofactor proteins. The cofactor DnaJ delivers non-native client proteins to DnaK...
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RT @KiesslingGroup: Some fun weekend reading, anyone? @duganam @amanda_peiffer and @ChemicalBiology discuss methodological advances to bett….
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RT @DirkTrauner: Here is the 2007 "Survey of Sam's Syntheses", compiled with input from the entire Danishefsky research family. It needs to….
drive.google.com
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Especially thankful for support from @ChemicalBiology, Rob Brown @KiesslingGroup and @ChemistryMIT during my time here!.
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Thankful for this amazing team! Charlie Dulberger @chaaawie @ericrubinlab @HarvardChanSPH, Deb Hung’s group @broadinstitute, @BriegelAriane @LeidenBiology, and the Garner group @fleshball @MCB_Harvard.
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Phenotypic assays are powerful yet rarely report on the nuances of bacterial life cycle perturbation. We developed a chemical reporter of mycobacterial cell division and used it to understand antibiotic action.
biorxiv.org
The current understanding of mycobacterial cell envelope remodeling in response to antibiotics is limited. Chemical tools that report on phenotypic changes with minimal cell wall perturbation are...
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RT @KiesslingGroup: WOO for Wuo!🎊 @mike_wuo et al design a new probe to discover how the mycobacterial cell wall rearranges itself in the p….
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RT @ChemicalBiology: Fun collaboration spearheaded by @mike_wuo with @ericrubinlab the Hung group @broadinstitute, and the Garner group (@….
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