Mikayla Eppert
@mikayla_eppert
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Curious scientist interested in how genes are regulated 🧬 | PhD in Sabari Lab at UTSW | University of Iowa alumna 🌽
Dallas, TX
Joined March 2022
I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. https://t.co/AQlErs3lni.
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🌌 Dive into the world of RNA Pol II, where tiny "alien" is actually clusters of Pol II CTD in different post-translational modes, forming distinctive phase-separated droplets with unique role in transcription. Check out our new paper just published 👉 https://t.co/yM9aaCdsl3
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Checkout the latest work from the lab online today in @MolecularCell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by @Nancybrillet @Prashan10011102 and @TvReshma .
Online Now: Disorder-mediated interactions target proteins to specific condensates https://t.co/yNMDWlDOLQ
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Congratulations to @mikayla_eppert for recieving the NOA for her NRSA F31 fellowship! Thank you to @NIGMS for supporting Mikayla's work on mechanisms of condensate-mediated transcription regulation. This is well deserved recognition of an outstanding graduate student #ProudPI.
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Congratulations to the 2024 Nominata Award Recipient and Finalist! Heankel Lyons and Dr. Tony Zhang's work has been recognized for their commitment to impactful biomedical research and embodying the collaborative spirit of UT Southwestern.
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Communicating complex research topics to non-science audiences can be tough. I am ecstatic to spend the next year learning how to present my research to all audiences as a part of the @ARVOinfo science communication training fellowship! #SciCommTF
2024 @ARVOinfo Sci Comm Fellowship cohort is listed. So excited to see @emilyrnett on there! https://t.co/oGC1wDakTg
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Fantastic work spearheaded by @peihengg_heart (@Transactivator lab) and @mikayla_eppert (@bsabari lab) showing that the transcriptional coactivator MYOCD forms condensates to activate cell identity genes in a switch-like and dosage-dependent manner. 1/3 https://t.co/KkPz4yZDQo
science.org
Myocardin activates cardiovascular gene expression by formation of transcriptional condensates.
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Excited to share a new collaborative paper from my lab and the @transactivators lab where we find that condensate formation of the cell type specific coactivator Myocardin drives gene activation during cardiovascular differentiation. https://t.co/ZYKNWknHb4
science.org
Myocardin activates cardiovascular gene expression by formation of transcriptional condensates.
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Happy to share our new paper on the role of myocardin phase separation in cardiac and smooth muscle specification @bsabari, @peihengg_heart, @mikayla_eppert Coactivator condensation drives cardiovascular cell lineage specification | Science Advances
science.org
Myocardin activates cardiovascular gene expression by formation of transcriptional condensates.
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Excited to shared my first publication in the @bsabari in @ScienceAdvances . We combine expertise from cardiovascular development (with a huge thanks to @peihengg_heart and @Transactivator lab) and condensate biology to understand lineage specification. https://t.co/6EPdN4qRwp
science.org
Myocardin activates cardiovascular gene expression by formation of transcriptional condensates.
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Our paper is out in today's issue of @CellCellPress. Thanks to @DrawImpacts for working with us on the cover art. Credit to @mikayla_eppert for coming up with this idea to illustrate how condensates organize the complex and heterogenous environment inside the cell.
Excited to share the first paper from my lab. We show that condensates composed of the disordered region of MED1 selectively partition specific functionally related proteins from a complex mixture of biomolecules, regulating gene activation. Free link: https://t.co/DXSHVNDGS9
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The first paper out of the newly established @bsabari lab, and it's a big one! Published in @CellCellPress "Functional partitioning of transcriptional regulators by patterned charge blocks" shows how the IDR of MED1 selectively partitions proteins https://t.co/NxQf6RGuL2
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Happy holidays from the lab! Congrats to this group for a fantastic 2022 and an exciting 2023 to come.
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Check out the preview that @mikayla_eppert and I wrote on a new study from @LilingWanLab and Haitao Li. Also, congrats to them on getting the cover. 50 day free link:
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