RT @mbeisen: Scientists and universities: defend indirects as a concept but not current indirect rates. Don't think there's waste in those….

Special thanks to Adam Palmer's lab, Matt Vander Heiden's lab, Omer Yilmaz's lab, and the folks at Genentech, all of whom were instrumental in this 5-FU story about RNA damage! Collaborative science is always the best!.

Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - The whole thing started when Karl and Jung-Kuei were trying to figure out hiow limiting dNTPS skewed DNA repair. Never thought it would be RNA and tge ribosome!.

Thrilled to share this latest work led by Xiao-Kang Lun in Peng Yin's lab and Xueyang Yu in mine. Finally, single cell signaling can begin to rival single cell RNA-Seq, using CyTOF, phospho-antibodies and ACE amplification.

RT @mbeisen: This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promot….

Thrilled to share our characterization of the human tyrosine kinome. Try out the public website: Wonderful collaboration with @CantleyLab @benturklab @LabYaffe. Many years of work led by Jared Johnson!.

This is a really important thread from Lior Pachter about the mathematical underpinnings of scRNAseq.

Excited to share our latest story - JNK and Erk MAPK signaling controls senescence from damaged replication forks, and at later times drives the SASP. Means MEK inhibitors with topoisomerase chemo likely to be a bad combo!.

This is truly brilliant….

Fantastic motifs and signaling meeting at EMBL the last 2 days in honor of Toby Gibson.

RT @a_navickas: Links between translation and alternative polyadenylation in metastasis? The story is out today! A great collab between @ge….

Very grateful to our collaborators at Genentech, Adam Palmer's lab, @ac_palmer, Matt Vander Heiden's lab, @mvh_lab, and Omer Yilmaz's lab @ohyilmaz, and of course the Koch Institute! @kochinstitute.

In the bioRxiv paper, we find that 5-FU shows no synergy at the cellular level with the DNA damaging drugs oxaliplatin or irinotecan - the combination given for GI cancer Rx. Instead, ribosome and tRNA biogenesis is impaired, driving an apoptotic signal that does not require p53.

RNA Damage? Happy to share Jung-Kuei Chen and Karl Merrick and @LabYaffe preprint that reports the major mechanism of 5-FU action in clinically relevant cancer treatment is through damage to structured RNAs.

RT @GS_Lab_Bham: Great work from the @davidkcortez lab!.

RT @mbeisen: If we didn’t have tenure scientists never would have risen up to discard our dysfunctional publishing system.

Congrats to Justine Stehn, Scott Floyd, and Yi Kong on what I hope will be the first of a series of papers showing alterations in protein translational control after DNA damage through stress signaling and 14-3-3.

RT @UCPH_CPR: Despite our scientific success @novonordiskfond will close CPR due to new funding strategy. #forskpol #DKforsk.We applaud our….