Michael Yaffe
@mbyaffe
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Professor at MIT, Surgeon-Scientist. DNA damage signaling, protein kinases, precision cancer medicine, signaling in tumor microenvironment
Boston, Massachusetts
Joined September 2009
Scientists and universities: defend indirects as a concept but not current indirect rates. Don't think there's waste in those numbers? We (US science) spend $4.5 billion on journals. That is HALF of the proposed cuts in indirects, and eliminating that spending would make science
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Special thanks to Adam Palmer's lab, Matt Vander Heiden's lab, Omer Yilmaz's lab, and the folks at Genentech, all of whom were instrumental in this 5-FU story about RNA damage! Collaborative science is always the best!
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Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - https://t.co/yZhVYKhOQA. The whole thing started when Karl and Jung-Kuei were trying to figure out hiow limiting dNTPS skewed DNA repair. Never thought it would be RNA and tge ribosome!
cell.com
5-fluorouracil’s utility in cancer treatment has been attributed to inducing dNTP imbalance and DNA damage in cancer cells. Here, Chen et al. demonstrate that 5-FU’s efficacy results instead from RNA...
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https://t.co/s7h7TWriLx Thrilled to share this latest work led by Xiao-Kang Lun in Peng Yin's lab and Xueyang Yu in mine. Finally, single cell signaling can begin to rival single cell RNA-Seq, using CyTOF, phospho-antibodies and ACE amplification.
nature.com
Nature Biotechnology - Mass cytometry with signal amplification enables measurement of low-abundance proteins.
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This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promoted a culture where the primary goal of science is to produce bloated Nature papers that require lots of time and money, but little thought, to produce.
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Thrilled to share our characterization of the human tyrosine kinome. Try out the public website: https://t.co/a5zfETTzCf Wonderful collaboration with @CantleyLab @benturklab @LabYaffe. Many years of work led by Jared Johnson! https://t.co/UsmA3wE78P
nature.com
Nature - An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase...
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This is a really important thread from Lior Pachter about the mathematical underpinnings of scRNAseq.
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Excited to share our latest story - JNK and Erk MAPK signaling controls senescence from damaged replication forks, and at later times drives the SASP. Means MEK inhibitors with topoisomerase chemo likely to be a bad combo!
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Fantastic motifs and signaling meeting at EMBL the last 2 days in honor of Toby Gibson.
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Links between translation and alternative polyadenylation in metastasis? The story is out today! A great collab between @genophoria, @AndreiGoga_SF and @FKHM labs! Shout out to co-authors @Gentremet, @JulianeScience, @lisacfishsci among others!
nature.com
Nature Cell Biology - Using ribosome profiling, Navickas et al. show that heterogeneous nuclear ribonucleoprotein C functions with PABPC4 to regulate alternative polyadenylation of a set of mRNAs,...
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Very grateful to our collaborators at Genentech, Adam Palmer's lab, @ac_palmer, Matt Vander Heiden's lab, @mvh_lab, and Omer Yilmaz's lab @ohyilmaz, and of course the Koch Institute! @kochinstitute
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In the bioRxiv paper, we find that 5-FU shows no synergy at the cellular level with the DNA damaging drugs oxaliplatin or irinotecan - the combination given for GI cancer Rx. Instead, ribosome and tRNA biogenesis is impaired, driving an apoptotic signal that does not require p53
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RNA Damage? Happy to share Jung-Kuei Chen and Karl Merrick and @LabYaffe preprint that reports the major mechanism of 5-FU action in clinically relevant cancer treatment is through damage to structured RNAs... https://t.co/jXpSZkiP7l.
biorxiv.org
5-fluorouracil (5-FU) is a successful and broadly used anti-cancer therapeutic. A major mechanism of action of 5-FU is thought to be through thymidylate synthase (TYMS) inhibition resulting in dTTP...
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If we didn’t have tenure scientists never would have risen up to discard our dysfunctional publishing system
What is your elevator pitch for academic tenure? That will resonate with your non-academic, working person neighbors?
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Congrats to Justine Stehn, Scott Floyd, and Yi Kong on what I hope will be the first of a series of papers showing alterations in protein translational control after DNA damage through stress signaling and 14-3-3.
frontiersin.org
14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cel...
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Despite our scientific success @novonordiskfond will close CPR due to new funding strategy. #forskpol #DKforsk We applaud our visionary leader Jiri Lukas for creating a global flagship in protein research whose pioneering spirit will live on #CPRlegacy. How did he do this? 👇🧵
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