María D. Moya-Garzon
@mariadolores_mg
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Postdoc at Long Lab @longlabstanford @stanford | Former PhD student at @ffarmaciaugr @canalugr
Stanford, CA
Joined August 2017
Thrilled to see my postdoc work is out in @CellCellPress! Here we uncovered a β-hydroxybutyrate shunt pathway that generates anti-obesogenic ketone metabolites called BHB-amino acids. Big thanks to all collaborators, @LongLabStanford and @WuTsaiAlliance .
www.cell.com
Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.
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RT @Fundame_org: Felicitamos a nuestra antigua becaria, Dra. María Dolores Moya Garzón @mariadolores_mg por su interesante publicación en….
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Really excited to participate at Miami Symposium and to present our recent work on ketone metabolism!
www.cell.com
Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.
Look who is speaking in the dietary intervention session at Miami Symposium on Human Metabolism! @eclien @VAInstitute, Eric Ravussin @PBRCNews, & @mariadolores_mg @longlabstanford @StanfordMed. If you love mechanisms & metabolism you'll love this session!
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RT @CellCellPress: Now online! A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites
www.cell.com
Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.
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RT @Stanford_ChEMH: New research from @mariadolores_mg and @LongLabStanford identifies a new metabolic pathway that helps explain the molec….
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RT @WuTsaiAlliance: Congrats to the @stanford team on their new research in Cell! They’ve discovered a new metabolic pathway in mice during….
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RT @longlabstanford: Today in @CellCellPress we report a new pathway of ketone metabolism. This BHB shunt generates an orphan family of ano….
www.cell.com
Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.
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Lastly, we also observed that the CNDP2-mediated amino acid BHB-ylation and BHB-amino acid metabolites are conserved in humans
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In collaboration with @DrYongXu1, we used TRAP (targeted recombination in active populations) and observed that pharmacological administration of BHB-Phe activates several hypothalamic and brainstem regions implicated in feeding behaviors
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In contrast, CNDP2-KO showed increased food intake and body weight after exogenous ketone ester supplementation or a ketogenic diet
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We next used gain-of-function approaches with BHB-Phe, the most abundant BHB-amino acid. In these experiments, we observed that pharmacological administration of BHB-Phe reduced food intake and body weight in obese mice
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After that, we examined the contribution of the enzymes CNDP2 (BHB-amino acid synthetase) and HMGCL (ketogenesis enzyme) to BHB-amino acid production in vivo
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Using targeted metabolomics and comparing BHB-amino acids chemical standards and mouse plasma, we were able to identify BHB-amino acids as endogenous mouse metabolites. Furthermore, we observed that BHB-amino acids plasma levels were elevated following diverse ketosis stimuli
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Next, we used tissues from WT and CNDP2-KO mice to determine if endogenous CNDP2 catalyzes amino acid BHB-ylation in mouse tissues. We observed that genetic ablation of the CNDP2 enzyme eliminates BHB-ylation activity and reduces levels of BHB-amino acids
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We first used in vitro enzymatic assays to characterize the activity of CNDP2 synthetizing BHB-amino acids
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In this work, we have identified a previously undescribed BHB metabolic pathway in which the enzyme CNDP2 catalyzes the conjugation of BHB with free amino acids to produce BHB-amino acids
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Amazing day of science at the Pathology retreat today and thrilled to receive this award! Thank you @StanfordPath @longlabstanford.
And @mariadolores_mg !! @Stanford_ChEMH.
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Really excited to share our recent discovery of a novel pathway of B-hydroxybutyrate metabolism linked to energy balance! Thanks to @longlabstanford and all collaborators!
www.biorxiv.org
β-hydroxybutyrate (BHB) is an abundant ketone body. To date, all known pathways of BHB metabolism involve interconversion of BHB and primary energy intermediates. Here we show that CNDP2 controls a...
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RT @longlabstanford: Beautiful video summarizing our work from @BrainResilience, featuring @mariadolores_mg @veronical1411 @skxiao_nju. Tha….
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