Liang Chang
@liangc_science
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Life Science VC @ AditumBio | Views are my own 🧬📖 ✍️
Cambridge, MA
Joined January 2014
Excited to share that my main PhD paper @TheSellersLab is published on @NatureGenet ! We found that conditional pathway activation is a new class of cancer synthetic lethality, opening new opportunities for future cancer therapeutics. A Twittorial 🧵👇 https://t.co/w8PSFIWSFO
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On a side note, I’m working on a blog post + spreadsheet to summarize ~100 books related the science and business of biotech/life science, out of ~180 books I read in the past 3 years. Stay Tuned, and happy new year!
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10. The 16 Undeniable Laws of Communication by @TheJohnCMaxwell. Also as the name indicates, a nice book succinctly summarize key rules and tricks in communication, both to a large audience and in 1on1 settings.
amazon.com
It’s been said that public speaking is the number one fear of most people, with death being second. “This means,” said comedian Jerry Seinfeld, “if you have to be at a funeral, you would rather be in...
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9. A Man for All Markets by Edward O. Throp. Book about a legend who tried to solved every “game” he encountered in his life: math, blackjack, roulette, stock market (quant trading). Especially a fun book for me as a poker player! https://t.co/05V0V6OClU
amazon.com
A child of the Great Depression, legendary mathematician Edward O. Thorp invented card counting, proving the seemingly impossible: that you could beat the dealer at the blackjack table. As a result...
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8. The Good Life by Marc Schulz and Robert J. Waldinger. Findings of the longest study of human happiness, highlighting the importance of building and maintaining close-knit relationships with people close to us for our happiness.
amazon.com
What makes a life fulfilling and meaningful? The simple but surprising answer is: relationships. The stronger our relationships, the more likely we are to live happy, satisfying, and healthier lives....
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7. How to Know a Person by @nytdavidbrooks As the name indicates, a great book on how to understand others better and build better connections with other human beings.
amazon.com
As David Brooks observes, “There is one skill that lies at the heart of any healthy person, family, school, community organization, or society: the ability to see someone else deeply and make them...
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6. Elon Musk by @WalterIsaacson Another epic Walter Isaacson book that doesn’t need an introduction. An enjoyable read if you want to learn more about Elon and many things behind the headline.
amazon.com
When Elon Musk was a kid in South Africa, he was regularly beaten by bullies. One day a group pushed him down some concrete steps and kicked him until his face was a swollen ball of flesh. He was in...
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5. Career Imprints by Monica C. Higgins. This is a book published a while ago but definitely worthwhile for biotech folks, on how Baxter trained a generation of biotech leaders.
amazon.com
Based on her research of 800 biotechnology companies and 3,200 biotechnology executives, Harvard Business School professor Monica Higgins discovered that one firm–Baxter–was the breeding ground for...
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4. Brain Storms by Jon Palfreman. A book about the history of Parkinson’s disease, written by a journalist and PD patient with the first-person perspective.
amazon.com
Brain Storms: The Race to Unlock the Mysteries of Parkinson's Disease
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3. Living Medicine by Fred Appelbaum. A book about the history of hematopoietic stem cell transplant, story about Don Thomas, Fred Hutch and many scientists makes the impossible possible
amazon.com
In the last half of the twentieth century, Thomas himself discovered a cure for every marrow-based disease—like leukemia, lymphoma, and sickle-cell anemia—forever changing treatment for some of the...
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2. Malady of the Mind by Jeffrey A. Lieberman. The comprehensive "biography" of schizophrenia, the story of generations of scientists and clinicians understanding and treating this terrible disease.
amazon.com
This “incredibly captivating” (Siddhartha Mukherjee, author of ) portrait of schizophrenia, the most malignant and mysterious mental illness, by renowned psychiatrist Jeffrey Lieberman, interweaves...
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1. For Blood and Money by @nathanvardi. One of my favorite biotech books, beautiful stories behind the science and business of BTK inhibitors.
amazon.com
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First, here's my complete 2023 book list. All non-fiction, by genre: Medicine/Biotech (n=21), Business/Finance/Biography (n=19), Psychology/Development (n=15), Macro/politics (n=2). Among n=50 books in English, below is my top 10👇
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After finishing 57 books in 2023, here are my top 10 🧵 👇
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Read this week's Cancer Discovery #ResearchWatch: Hyperactivation of Oncogenic Pathways Hinders #CancerCell Survival, summarizing the work of @liangc_science, @TheSellersLab et al. https://t.co/XKpgYlFWcv
@broadinstitute @DanaFarber @harvardmed
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Great article featuring my PhD work and our recent publication by @leilei_wuu @endpts
For decades, cancer drug developers have focused on inhibiting certain cancer-driving pathways. A startup backed by Google's venture arm GV is now trying to do the opposite — overactivate those pathways to kill tumor cells. https://t.co/nmoooZIiF8
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Mind the gap! New paper (and company) from @TheSellersLab and @broadinstitute systematically studies growth pathway *activation* in cancer, with therapeutic intent. While already established conceptually, this systems effort to target the third rail of cancer medicine will be
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Thanks for highlighting our work!
Cancer targeted therapies are based on inhibition of critical pathways. In this manuscript, conditional activation of signaling pathways allows to leverage activation lethality to create a new class of cancer medicines. https://t.co/i1Rmsfrucg
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Finally, a readtube link if you want to get the PDF directly! https://t.co/eFCilhUraq
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(6/6) Very grateful for the mentorship and support from my PhD advisor Bill Sellers, and collaborators from @TheSellersLab, Broad PRISM lab and CCLF. Also super grateful for this great News & Views article from @kcw00d
https://t.co/ni8lRD5AkI
nature.com
Nature Genetics - Many precision cancer therapies function by inhibiting oncogenic signaling pathways. A new study describes the counterintuitive finding that forced hyperactivation of the same...
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(5/6) Taken together, our study indicates that cancer cells are not only vulnerable to loss of key signaling pathways, but also vulnerable to hyperactivation of these signaling. Our finding could serve as a foundation for a new therapeutic concept: targeted pathway activation.
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