Stemcellbiology Aachen
@lab_wagner
Followers
109
Following
7
Media
3
Statuses
76
We focus on molecular and epigenetic mechanisms that regulate human stem cells, particularly hematopoietic, mesenchymal and induced pluripotent stem cells.
Aachen, Germany
Joined July 2018
Aging is more than just a line. Instead of multivariate models epigenetic clocks can also be trained as a probablistic model on 2D-kernel density estimation:
0
0
1
There is a network between epigenetic clock sites! I am happy to share this preprint on our recent study:
0
0
1
Cancer shapes it microenvironment. Cancer associated fibroblasts #CAF become activated and reprogrammed and this is even reflected in their epigenome. We observed very similar changes in their DNA methylation pattern across different types of cancer. https://t.co/JPXIyNsggX
0
0
2
Substrate elasticity impacts differentiation and the epigenetics of iPSCs? It does apparent not... https://t.co/iuEq7nRO54
0
0
0
Proud to share this new preprint on cellular aging in myeloproliferative neoplasms. Our results indicate that cellular aging is accelerated in malignant MPN clones and this can provide a target for treatment with senolytic drugs or telomerase inhibitors. https://t.co/PPczREkMAk
medrxiv.org
Myeloproliferative neoplasms (MPNs) are caused by somatic driver mutations, such as JAK2 V617F, which might also affect cellular aging and senescence. Here, we analyzed the heterogeneity of aging in...
0
0
3
This week, our Institute for Stem Cell Biology had a Lab-Retreat in Trier. We had very stimulating discussions about science and future perspectives for research and lab-organization. IT REALLY IS A PRIVILEGE TO WORK WITH SUCH A FANTASTIC TEAM!!!
0
0
3
YAP! It is essential! It is a pleasure to share this work of Kira and coworkers demonstrating that YAP1 is essential for self-organized differentiation of pluripotent stem cells. https://t.co/Ky7zjmj2zN
0
0
5
We have an open PhD position on epigenetics in leukemia (myeloproliferative neoplasms). It rocks - please share @MPN @stemcells @leukemia @EpiExperts
0
0
1
Are your iPSC realy pluripotent? GermLayerTracker is a new biomarker to track differentiation toward endoderm, mesoderm, and ectoderm. This work was driven by three fantastic PhD students.
0
0
2
If you are interested YAP, please have a look at our preprint.
0
0
0
Hematopoietic differentiation remains possible in iPSC with #DNMT3A knockouts. We collected this data for more than 4 years and we are glad to now see it published at BMC Biology. Congratulations to Olivia and everybody involved. https://t.co/8PMLdK4A9o
bmcbiol.biomedcentral.com
Background DNA methylation is involved in the epigenetic regulation of gene expression during developmental processes and is primarily established by the DNA methyltransferase 3A (DNMT3A) and 3B...
0
1
1
Our new study on age-associated DNA methylation in mice was just published. There are marked differences between mouse strains. https://t.co/2rfLOqms5E
frontiersin.org
Aging of mice can be tracked by DNA methylation changes at specific sites in the genome. In this study, we used the recently released Infinium Mouse Methylat...
0
0
2
Between murine mouse strains the methylome and age-associated DNA methylation may differ almost as much as between wild type individuals.
0
0
3
A brief review on how to translate DNA methylation biomarkers into clinical practice.
0
0
1
Imagine leukocyte counts with a simple finger prick. #EpiBloodCount can provide standardized analysis of leukocyte subsets from dried or frozen blood. https://t.co/qmvWxRi7l5
0
0
2
Please check our new Biomaterials article. Congratulations Mohamed :) https://t.co/FQqmsLvRns
0
1
3
DNMT3A knockouts in human iPSCs prevent de novo DNA methylation and reveal growth advantage during hematopoietic differentiation
biorxiv.org
DNA methyltransferase 3A ( DNMT3A ) is a frequently mutated gene in many hematological malignancies, indicating that it may be essential for hematopoietic differentiation. Here, we addressed the...
0
0
1
We are looking for Ph.D. candidates to work on (1) bioinformatics for multi-modal single cell/spatial omics on kidney disease with @KuppeChristoph and (2) impact of age related DNA methylation on gene regulation with @lab_wagner . Details https://t.co/RHpiYoRb4V . Please RT
0
26
34
In our latest publication we investigated if #DNAmethylation changes during in vitro cell culture are caused by epigenetic drift. Check out our new #epigenetics paper in @CommsBio
https://t.co/MBUU2nkWF2
0
2
5
We are proud to present our small contribution to the global efforts on #COVID19 research: our results indicate that #epigenetic #ageing is not accelerated in patients infected by #SARSCoV2. Check our new preprint here: https://t.co/Nf1jAGAEGm
medrxiv.org
Age is a major risk factor for severe outcome of coronavirus disease 2019 (COVID-19), but it remains unclear if this is rather due to increased chronological age or biological age. During lifetime,...
1
0
2