Peter Kjer-Hansen
@kjer_peter
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PhD candidate @GarvanInstitute in @Neuro_RNA lab. Interested in all things RNA, although especially alternative splicing and the protein diversity this enables!
Sydney, Australia
Joined December 2019
Splice up your life!. Excited to share our new Review on the potential of thinking protein isoforms when it comes to therapeutics!. Link: Written with @Neuro_RNA @LabPhan . A short overview🧵
Protein isoform-centric therapeutics: expanding targets and increasing specificity Many genes encode multiple protein isoforms. This new review discusses targeting isoforms as a route to drugs with greater specificity and fewer adverse effects
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RT @MolecularCell: Online Now: Isoform-specific function of NSD3 in DNA replication stress confers resistance to PARP inhibitors in prostat….
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RT @PatrykPolinski: Thrilled to share my 1st PhD paper, exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬 #PhD….
nature.com
Nature Communications - Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin...
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RT @ShorterLab: Protein isoform-centric therapeutics: expanding targets and increasing specificity:
nature.com
Nature Reviews Drug Discovery - Multiple protein isoforms arise from most genes by alternative RNA splicing and other mechanisms, but these isoforms are often neglected in drug discovery. This...
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RT @mirimiam: The job call is officially open. If you're interested, please apply through this link ASAP! 😃. Pleas….
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RT @mirimiam: 🐟Our new paper "Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish" is ou….
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RT @JJLucasLab: Finally out the study (led by @xsalvatella1 & @RMendezLab) with the biophysical explanation for the….
nature.com
Nature - The molecular mechanisms of how small changes in the degree of inclusion of a neuron-specific microexon in CPEB4 lead to dominant-negative effects in the expression of genes associated...
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RT @Gabeechuela: The last part of my PhD research 🤓 is out!! If you are interested in RNA Biology -> Alternative Splicing and Epitranscript….
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RT @mirimiam: 🚨🚨🚨 Very excited to share our new preprint on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4:….
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RT @Neuro_RNA: Excited to share our new review discussing potential of targeting isoforms as a new route to drugs with greater specificity….
nature.com
Nature Reviews Drug Discovery - Multiple protein isoforms arise from most genes by alternative RNA splicing and other mechanisms, but these isoforms are often neglected in drug discovery. This...
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We finish off with discussing future perspectives and challenges relating to protein isoform-centric therapies! Link: @GarvanInstitute @UNSW @NatRevDrugDisc.
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Lastly, protein isoforms also have clinical potential independently of whether they have distinct functions or not (function-agnostic). We discuss how they can serve as neoantigens in cancer, as unique molecular targets for directed drug delivery, and as diagnostic biomarkers
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We discuss each approach and showcase how protein isoform-centric therapies can offer treatment options for diseases with current treatments. We also discuss how isoform-level targeting increases specificity which may enable drugging of proteins where global inhibition is toxic
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We outline 3 distinct, though often overlapping ways in which protein isoforms with distinct functions can be used or targeted therapeutically: 1) Splice modulation to switch protein isoform usage, 2) Protein isoform depletion or introduction, 3) Modulation of isoform activity
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Alternative splicing generates protein isoforms with unique functions whose absence or presence can cause or modulate disease
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RT @NatRevDrugDisc: Protein isoform-centric therapeutics: expanding targets and increasing specificity Many genes….
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We finish off with discussing future perspectives and challenges relating to protein isoform-centric therapies!.Link:
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Lastly, protein isoforms also have clinical potential independently of whether they have distinct functions or not (function-agnostic). We discuss how they can serve as neoantigens in cancer, as unique molecular targets for directed drug delivery, and as diagnostic biomarkers
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We discuss each approach and showcase how protein isoform-centric therapies can offer treatment options for diseases with current treatments. We also discuss how isoform-level targeting increases specificity which may enable drugging of proteins where global inhibition is toxic
1
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We outline 3 distinct, though often overlapping ways in which protein isoforms with distinct functions can be used or targeted therapeutically: 1) Splice modulation to switch protein isoform usage, 2) Protein isoform depletion or introduction, 3) Modulation of isoform activity
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