Kevin Sek
@kevin_sek
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Joined August 2017
It was a pleasure to contribute to this article on CAR T exhaustion @Cancer_Cell
cell.com
CAR T therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of chimeric antigen receptor (CAR) T cell...
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Very proud to share the latest work from the lab. This work describes a new methodology to enhance the activity of CAR T in solid tumours through CRISPR- mediated deletion of the adenosine A2AR
nature.com
Nature Communications - Activation of the adenosine receptor A2AR is associated with suppression of T cell function in the tumor microenvironment. To overcome immunosuppression, here the authors...
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Ever wondered how a T cell decides to be anergic vs exhausted? We identify the anergy-associated transcription factor Egr2 as a key regulator of CD8+ T cell exhaustion, with some surprising results that may answer this question. Take home messages below(1/) https://t.co/QsSgtTmseG
nature.com
Nature Communications - Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models...
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Interested in working on developing CAR T cells & strategies to improve their trafficking? We are now hiring for a research assistant perfect for someone wanting to develop skills working alongside one of the best @ImranHouse. Closes 19th March. Link👇 @PeterMacRes @ASImmunology
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We're back babyyy with an all new episode for the Lunar New Year! Join us as we try and figure out the science behind those health myths our Asian parents told us! #CNY2021 #CNY #science
#scicomm #AcademicChatter #phdchat
https://t.co/3M681bEWjU
open.spotify.com
Pear Review Club · Episode
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Hi everyone! Super excited to be here! I’m @jack_chan15 and I’ll be your host this week! [Big thnx to @prksrng and @SciCrastina]! Here’s my schedule for the week
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Here's my @iamscicomm schedule for next week! I'll be focusing on #film, #video and moving media, so hit me up if you need to make video or if you're movie buff yourself! 🎥x🧪
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We are currently looking for a post doc to join our team. Project will investigate a new approach to enhance CAR T in solid tumours through engagement of host immunity. @ASImmunology @PeterMacRes @JunyunLai
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SPOTLIGHT: IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors @PeterMacCC @paulbeavis4 Originally published in @MolTherapy To read our summary click https://t.co/Dj0QlSeNUa and scroll all the way down.
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Cells use their machinery to multitask. Here @JonathanPojer finds 2 parts of the Hippo Swiss army knife that control cell fate as well as organ growth. First 1st author paper for Jonathan - congratulations! @PeterMacRes @MonashBDI
biorxiv.org
The Hippo pathway is an important regulator of organ growth and cell fate. In the R8 photoreceptor cells of the Drosophila melanogaster eye, the Hippo pathway controls the fate choice between one of...
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A discrete population of CD8 T cells that bridge the gap between effector and memory subsets - Terminal Tem - Really glad I got to contribute to this story by @GoldrathLab @JJMilnerLab - thanks to @CancerResearch - check it out >
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Thinking about PhD or Honours? We’ll work with you to design a research project that fits your interests and the skills you want to learn within one of our themes. Join me for a chat at the open day
Our @PeterMacRes @PeterMacCC Virtual Research Student Open Day on Tuesday 15 Sep will look very different this year! Come check us out online and register now https://t.co/zn0IrLYQPZ
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Happy to share our latest review, written by @kevin_sek on the interplay between adenosine and adoptive cellular therapy, 2 topics of high interest to our lab. This issue of Current Opinion in Pharmacology has many great papers on adenosine in cancer.
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