Josh Peterson
@JoshPetersonMD
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Internist; Informaticist; Precision Medicine enthusiast; Professor at VUMC
Nashville, TN
Joined September 2013
Celebrating achievement of target enrollment in eMERGE IV at the Consortium meeting in DC ~25,000 enrolled (~20,000 adults, ~5000 children) in a study of returning polygenic risk scores in the clinical setting ~48% belong to health disparity groups @NHGRI_Director
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I am honored and thrilled to take on the role of Division Director for Genetic Medicine @VUMC_Medicine! As a junior faculty member, I benefited tremendously from mentorship and support from @NancyGenetics. I look forward to paying it forward @VUMCgenetics!
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@agbt @AnneOtation and I are very excited to offer this pre-conference workshop on genomic databases. Come join us at @agbt Precision Health!
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A single SNP in ~10% of US African Ancestry individuals causes a systematic decrease in HbA1c and a dramatic under treatment of diabetes. In @NatureMedicine led by @JosephBreeyear @JackieHellwege @genepiman_giri @toddledwards @VUMCDiscoveries
https://t.co/L2dWxyUYmV
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Please join us for NHLBI's 2-day virtual workshop “Return of Individual Research Results to Participants in Observational Cohort Studies” June 26-27. Focuses on incidental genomic results Link for the agenda & registration below https://t.co/xNBu03Ke0e
@nih_nhlbi @NHGRI
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Excited to share our paper published in Metabolism - Clinical and Experimental Congrats @JaneFFerguson @JDMosley_Moses @JaneFreedmanMD
https://t.co/F4e03f7qDN
metabolismjournal.com
Bariatric surgery improves metabolic health, but the underlying mechanisms are not fully understood. We analyzed the effects of two types of bariatric surgery, sleeve gastrectomy (SG) and Roux-en-Y...
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Congrats to @JDMosley_Moses, John Shelley and coauthors on another key study on how genetics help interpret laboratory values
news.vumc.org
People whose white blood cell levels are near the edge of the “healthy” reference range will hit a clinical decision point that has consequences such as diagnostic procedures and altered treatments.
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A @NatureGenet study, led by @VUMC_Cancer researchers, sheds light on some of the genetic variants that make #breastcancer more deadly for women of African ancestry and reduces the disparity in knowledge for assessing their genomic risk factors. https://t.co/mc4z6BrYA7
news.vumc.org
A study led by researchers from Vanderbilt-Ingram Cancer Center sheds light on some of the genetic variants that make breast cancer more deadly for women of African ancestry and significantly reduces...
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Excited to share our manuscript in @NatureComms looking at the clinical consequences of a polygenic predisposition to benign lower white blood cell (WBC) counts. @VUMCgenetics @VUMC_Medicine @vumcdbmi @VUMCHemOnc
https://t.co/jKODtgxjay
nature.com
Nature Communications - Here, the authors find that a benign polygenic predisposition to lower white blood cell counts is associated with multiple clinical endpoints, suggesting that predisposed...
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Excited to share @AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in @Nature
https://t.co/ph5Cd2Tq6I
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A huge eMerge Network effort to develop, validate, and clinically report PRS is now out in Nature Medicine https://t.co/SIk1lcHc3W
nature.com
Nature Medicine - A new study from the eMERGE consortium provides insights on the development of a pipeline for the generation and reporting of polygenic risk scores for ten diseases to diverse...
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The diagnostic odyssey is real in rare genetic conditions. Standardized #diagnosticdelay measurement & inclusion of low-income countries in diagnostic delay research are needed to develop systematic solutions https://t.co/MFUz73IgGD
@rozatinker @JoshPetersonMD @lisa_bastarache
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There were many excellent 2023 studies to consider, reflecting the incredible growth in efforts to use genomics in medicine. In case you have not read it already, I urge you to look at @AJGHNews!
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Join us for a panel on Challenges of Remote #Data #Harmonization and Querying at #PMWC24. Speaking are @HeidiRehm, Chris Lunt @NIH, Simona Carini @UCSF, @JoshPetersonMD and others! Details: Jan 26, 9:30 A.M. Track 2. More at https://t.co/uTYGt5hl6I.
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Data driven science and diversity in the @AllofUsResearch program: An informative summary by @AllofUsCEO @PersonalizedMed and @SheriSchully. Via @ScienceTM
https://t.co/Sa9kQkVGhk
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Can we precisely rewrite the genetic code - make a single DNA spelling change - in the liver of a human being for clinical effect? YES! Scientific milestone: VERVE-101 provides first proof-of-concept for in vivo DNA base editing in humans Clinical implication: It’s early
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Out in AJHG - large-scale return of sequencing results for >16,000 participants shows 44% received services in 1 year and modest mean $ increase in labs, procedures ($149). Many thanks to all our collaborators! https://t.co/WVEefO2RBj
@JacksonJodell @eMERGENetwork_
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This faculty opportunity is across biomedical informatics domains but please ask me about the extraordinary opportunities in Precision Medicine and Translational Bioinformatics at @VUMChealth @vumcdbmi
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A good read on PRS/PGS.
Polygenic risk scores: from fledgling genetic science to a murky market for prediction. Via @undarkmag
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Individuals homozygous for the HFE p.Cys282Tyr variant identified via genomic screening have clinically unrecognized evidence of iron overload and complete interventions known to reduce the risk of end organ damage.
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