Multiple Sclerosis, myelin production and splicing

RT @agingdoc1: Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation. @Cells….

3/3 The phenotype of ALS (and PD) is substantially driven by aberrant splicing, and hence a consequence of mitochondrial failure. There are a number of potential reasons for the dynamic equilibrium between the generation of ROS, neutralisation by anti-oxidants both endogenous to.

2/3 Neurodegenerative Diseases such as Parkinsons and ALS are caused by the failure of cells which both have a particularly high energy demand (in part linked to the need to maintain a large axonal arbour) and also a greater dependence on Oxidative Phoshphorylation. This means.

Hypothesis that ALS is caused by increased mitochondrial DNA damage as a result of an imbalance between ROS generation from the Electron Transport Chain and systems of antioxidants.

RT @BSRAgeing: We’ve had our largest ever number of abstract submissions for #BSRA2025! Congrats all, this is shaping up to be another grea….

@statto This has a broader potential interest from the public, whether it has a public interest as well depends upon a detailed analysis of the methodology which I have not done, but I thought you would like a heads up.

Do some "Fat Shots" come with a greater risk of vision loss? .

The effects of mitochondrial DNA damage on neurons

Have you looked at the side effects @statto.

Rapamycin's side effects are something to be aware of, but are I think controllable for, but trametinib is in a different league More common.Bleeding from the rectum or bloody stools.bleeding gums.blemishes on the skin.blistering, crusting, irritation,.

@alsadvocacy @mndassoc @mndresearch.

Interesting paper @alsadvocacy @mndreesearch @mndassoc.

Use of Common Psychiatric Medications and Risk and Prognosis of Amyotrophic Lateral Sclerosis (is this a result of a reduction in endogenous melatonin).

Transitions, Transversions and Deletions in mitochondrial DNA and their relevance to Parkinsons, ALS/MND and Aging.

Follicular Atresia and Mitochondria - Is this how the ovary picks the best egg with the best mitochondria?

Parkinsons and ALS/MND - Its the OxPhos!

ALS Hypothesis Evaluation

RT @agingdoc1: The mammalian longevity associated acetylome.

ALS, MND - is this another disease where biohacking has potential