John Cumbers
@johncumbers
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Join @SynBioBeta - May 5-8, 2025 in San Jose: https://t.co/pL2XIEZH0R and read my weekly newsletter: https://t.co/MQhYwiU1Ls
Joined April 2007
Everyone thought Bryan Johnson was insane. When they heard he spends $2,000,000 a year to live to 200. But the details of his protocol reveal 8 life-changing habits anyone can follow at home for free. Here's his evidence-based longevity blueprint: 🧵
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1. Sleep. Sleep is Bryan's #1 life priority. Asleep by 8:30pm and naturally wakes at 5:00am without an alarm. His sleep is so good he set a record: 8 months of perfect sleep scores with 2 hours of REM and 2 hours of deep sleep nightly. Here's how:
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@bryan_johnson In a recent video, @bryan_johnson said:. "I now have the best biomarkers of anybody in the world. I am the healthiest person on planet Earth.". His body temperature has dropped 5°F from metabolic improvements. His sleep quality tops 99.9% of people measured.
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Bryan's reduced his biological age by 5.1 years in just 7 months. Tests show his cells are aging more slowly than 92% of 18-year-olds. At 46, his body functions like someone in their 20s. Here're 8 habits you can learn from his $2M protocol:
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• NMN powder (1 gram daily).• Resveratrol (1 gram with fat).• Magnesium (400mg before sleep). He also takes a Blueprint Longevity mix with collagen peptides and creatine.
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Interested in Generative AI for BIO? Please Join George Church, David Baker and Sarah Carter for an interactive SynBioBeta Town Hall on "Generative AI for Protein Design: Balancing Risks with Opportunities". Tuesday Apr 16th at 12 noon pacific. You can register here:
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2. Morning light. First thing after waking, Bryan gets 10,000 lux light directly into his eyes for 3–4 minutes. He uses a special light device in winter, but natural sunlight works too. This morning light fixes his body clock and cuts his nighttime heart rate by 6 beats/minute.
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• 15 minutes flexibility.• 15 minutes balance work.• 30 minutes cardio (walking, biking).• 30 minutes strength (bodyweight + resistance bands). On weekends, he adds pickleball and rock climbing with friends.
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7. Exact food protocol. Bryan eats exactly 2,250 calories daily:. • 25% protein (141g).• 35% carbs (197g).• 40% fat (100g). "Super Veggie" lunch: lentils, broccoli, cauliflower, mushrooms, garlic, and ginger. His meals are plant-based by choice, not necessity for longevity.
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6. Workday movement breaks. Every 30 minutes, Bryan takes a 5-minute movement break. He rotates between standing and sitting desk. These mini-breaks keep blood flowing, body loose, and mind sharp. He says this habit alone boosted his work output by 34% in 3 months.
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8. Wind-down routine. Bryan's nighttime routine has one goal: lower his resting heart rate. He turns off all screens and at 7:00pm he takes a 10-minute outdoor walk. He reads physical books and does 5-minute breathing exercises to calm his nervous system.
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I just realized Rich Roll had one of the world's top longevity experts on his podcast. Peter Diamandis revealed some mind-blowing facts about human health & longevity that 95% of people never knew of. Here are my top 5 takeaways: 🧵
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4. Workout strategy. Bryan exercises 60-90 minutes daily, 7 days a week. His workout includes:.
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5. Targeted supplements. Bryan takes 104 pills daily (ridiculous for most people). But just 3 supplements give 80% of the benefits:.
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3. Daily body measurements. Bryan tracks his health obsessively every morning:. • Inner ear temperature (his dropped 5°F from metabolic improvements).• Body composition (fat, muscle, hydration).• Arterial stiffness. Simple smart scales can track most of these for under $100.
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20 years ago, synthetic biology was just a pipe dream. It was hard to engineer biology and ship product. It's now getting easier. Here's a list of 10 products of synthetic biology.
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Want to hear directly from Bryan himself?. He's speaking at the @SynBioBeta Hyperscale Biology conference on May 5-8, 2025 at the San Jose Convention Center. He'll share his latest protocols and the science behind his results. Grab a ticket here:
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By the end of 2025, extinct animals will roam the Earth again. Everything we know about restoration might be wrong. That's Dr. Jeanne Loring's prediction — the pioneer in de-extinction of the northern white rhinos. Here's everything you need to know: 🧵
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11 years ago today I started @SynBioBeta. I want to say a huge thank you to the SynBioBeta team, and to our community of CEO's, entrepreneurs, investors, sponsors, academics, students and change makers. The future belongs to biology, and belongs to you too.
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I am excited to be at the White House today for the Summit on Biotechnology and Biomanufacturing. It is a big week for biology policy. The federal government is pledging more than $2B to launch a National Biotechnology and Biomanufacturing Initiative 🧵1/
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Some great people have been pushing this bioeconomy policy boulder uphill for over a decade. Some great news out today from the Biden White House with a new bioeconomy executive order.
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Former finance minister, @MickeySpajic is Montenegro’s renaissance man. Fluent in Japanese, Mandarin and French, he’s creating a shining example of what a modern European leader can achieve with a focus on democracy, smart economics and smart tech policy. 1/
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Meet Dr. Jason Chin. He's a scientist who's dedicated 20+ years to rewriting DNA. His breakthrough? Creating cells immune to viruses and expanding the genetic code. Here's how a scientific revolution is changing medicine forever (evidence-backed): 🧵
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Toxins are POISONING us—slowly, silently, and PERMANENTLY:. - cancers.- brain damage.- fertility problems. You're attacked by 700,000+ dangerous toxins daily. And ONE company is putting it to an end. Here is the solution (& how to protect yourself): 🧵
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@VECTORCP @bryan_johnson Fair point 😂 The real results take decades. But early indicators - organ age, biomarkers - show promise. Worth watching.
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I'm joining the board of @iGEM! (International Genetically Engineered Machine Competition). Glad to bring an industry lens to the growth of the organization. Thanks to Randy Rettberg for the invitation. I'm excited for our first board meeting after the Jamboree in Paris
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Exciting news! @DrewEndy, founder of @iGEM /@biobricks, and @VitalikButerin, founder of @ethereum, will be joining the upcoming Synthetic Biology Summit on Sustainable Biomanufacturing for Future Network States. Best of all, it's free: 1/
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SynBioBeta is a wrap! Thanks to all our sponsors, speakers and attendees. I love our community. 😍😍😍🧬🧬🧬
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.@Ginkgo Bioworks, Inc. decided to open up some of its experimental services to the community in a royalty-free, IP-free manner. This is going to be a big deal for start-ups! Check out this exclusive interview with @jrkelly from @konvavitsas: .
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The DeSci movement is about giving “scientists more freedom to express their visions for the future and the ability to tackle them.” Check out my new Forbes article that looks at the current DeSci landscape.
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Follow me @johncumbers for more interesting insights on longevity science, synthetic biology, and updates from industry experts like Bryan Johnson. RT the post to spread the words.
Everyone thought Bryan Johnson was insane. When they heard he spends $2,000,000 a year to live to 200. But the details of his protocol reveal 8 life-changing habits anyone can follow at home for free. Here's his evidence-based longevity blueprint: 🧵
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Plus, you'll learn exactly how he's tracking his 78 organs for biological age. He'll appear alongside NASA astronaut Kate Rubins and Microsoft CTO Kevin Scott. Register below:
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How can we capture CO2 with microbes and make products from pollution? Synthetic biology is a powerful new tool for protecting our planet. Sounds like science fiction, right? Well here are 15 companies doing just this.
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Who is doing the most mind-blowing work at the intersection of AI and biology? Who is a great speaker you’d love to see talk about this at SynBioBeta?.
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We’ve had > 600 synbio students apply for SynBioBeta in May! We are giving away 100 conference passes. @ericschmidt & @SchmidtFutures are sponsoring 100 travel grants but we have a delta of 500! Want to support the next generation of bioeconomy entrepreneurs? Please let me know!
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Who are the most amazing speakers in biology who just blow your mind and teach you something new every time you hear them? Who are the Feynman-level communicators who carry you along and make you feel like a genius?.
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📅 20 years ago today, then MIT Professor @DrewEndy presented this groundbreaking briefing on #SyntheticBiology to the DARPA director. ( A moment that changed the trajectory of biological research forever. 🧬 1/7
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@tommuk00 @bryan_johnson Couldn’t agree more. Longevity isn’t about fearing death - it’s about maximizing the gift of life. While we’re here, let’s thrive and explore those deeper truths.
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From science fiction to life-saving reality: explore the remarkable revolution of gene editing with Dr. @davidrliu, the brilliant mind behind base and prime editing.
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Looking at nature and Imagining what the next 100 years of engineering biology will bring us.
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Whether you copy parts of Bryan's protocol or attend the conference, remember:. We're the first generation with tools to potentially extend our lives by decades. Which of these 8 longevity habits will you try?. P.S. This was Bryan back in 2018 with his @SynBioBeta Award
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Here are 10 incredible women leaders of #syntheticbiology:. 1. @EmilyLeproust, CEO & Co-founder @TwistBioscience.2. @rwegrzyn, Director @ARPA_H.3. @MaryEMaxon, Executive Director of BioFutures, @SchmidtFutures.4. Jennifer Holmgren, @TodaDogs CEO @LanzaTech.
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.@Ben_Reinhardt has always wanted to make the imaginings of science fiction novels a reality. He got his PhD with the goal of building spaceships; but became disenchanted with the existing venues for scientific and technological research. 1/
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I give up - I can't keep track of all the people and companies doing amazing work in generative AI and Bio. Please can you help tag them below? 🧬🙏🙏🙏🧬.
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A new company called Cradle wants to democratize protein engineering. Their team has created generative software that is like #DALLE2 but for protein design. I spoke with Cradle's CEO @stefvangrieken to understand what that means for #SynBio. 1/3.
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Exciting news for SynBioBeta next week! We're unveiling our Market Map featuring 129 sponsors, exhibitors & partners. The event will span 3 immersive days of content, delving into Biopharma, Climate, Food, Chemicals & Materials, Capital Markets, and more
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A rousing standing ovation for @AndrewYang’s TED talk. Worth 10 minutes of your time.
What if I told you we could meaningfully rationalize American politics for only 2% of what the 2 major parties will spend this year?
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@DavidKorsa_ @bryan_johnson Fair observation. “Looking young” and “being biologically young” aren’t always the same - but optics definitely matter. It’s a fascinating (and imperfect) experiment.
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What’s the holy grail of biology? This startup says it’s engineerable cells, and with $200million of new funding for their CAD platform to program genetic circuits, the manufacture of biological therapeutics is set to radically change. Read how:.1/.
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Synthetic Biology Has Raised $12.4 Billion. Here Are Five Sectors It Will Soon Disrupt. via @forbes.
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.@Genomatica announced the first commercial production of bio-based nylon, potentially disrupting a $10 billion market that now produces 60 million tons of greenhouse gas emissions annually. #synbio #biotech #biomanufacturing #sustainable #biomaterials.
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It's been a huge week in DNA reading this week, with the @Illumina Genomics Forum in San Diego. There was a star-studded appearance from the likes of @BarackObama and @BillGates. The big news out this week is the falling cost of reading a whole human genome. 1/
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There are 50+ synthetic biology investment funds coming to SynBioBeta this year! If you’re a synthetic biology #startup raising money right now, check 'em out below: 2048 Ventures.age1.Ajinomoto Corporate Venture Capital.ARK Investment Management LLC
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There's a huge shift happening from petro to bio: in September the White House issued an executive order developing a strategy for the $1T US Bioeconomy. In March it published a set of 'bold goals'. I'm going to highlight some of the key people turning the wheels of government.
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👏👏👏Please join me in congratulating Geoffrey Otim @otimgeoffrey25 from Uganda, founder of @SynBioAfrica. He’s here in the Bay Area to receive this year’s @SynBioBeta Impact Award On Thursday in Oakland! 🕺🏼🚀🧬
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.@TwistBioscience is a whale in the world of #DNAsynthesis and #NGS. Their annual earnings grew from $2M in 2016 to $203M projected for 2022. And now it’s eyeing the $186 billion #antibody market. Will the move into #biopharma help Twist reach EBITDA breakeven in 2023?.
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.@LanzaTech is on fire! This time taking on the ethylene industry! Today, the company announced it has engineered biocatalysts to produce ethylene from CO2 in a continuous process. 1/
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I am excited to share that Thomas Middleditch, star of the critically acclaimed HBO series “Silicon Valley”, turned climate investor, will be speaking at SynBioBeta with @sethbannon, Founder of VC firm @fiftyyears, on his passion for climate tech investing
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In 2004, Dan Gibson was drawn to a project at the J. Craig Venter Institute: to build a synthetic cell from scratch. Within days, he was on a path to creating synthetic life alongside genomics pioneers. 1/
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These amazing dinoflagellates are saltwater bioluminescent microbes that light up the oceans at night! You’ll be able to play with them at the @SynBioBeta conference on May 7th in San Jose. Courtesy of my good friend Andy Bass at Popular Biology. 🧬 🧬🧬
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Check out this new funding opportunity: How to get to Biology Engineered for Exploration of Space. The Translational Research Institute for Space Health (TRISH) is seeking proposers with proof-of-concept engineering biology solutions that can be used in long-duration, deep space
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Hanging at @fiftyyears HQ last night - the lull before the SynBioBeta storm. Thanks to @sethbannon for the photo.
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Young people in Uganda are shaping the future of climate, food and healthcare using the tools of synthetic biology. Please join me in supporting the Ugandan IGEM team here!.
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Hi @SynBioBeta family, you're the reason awesome people agree to come speak to our community. Please join me in welcoming the *one and only* @Paulstamets - the undisputed Mushroom King. We’ll see you in Oakland next May! 🍄🍄🍄😀😀😀🚀🚀🚀
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1. The longevity mindset. Peter believes mindset is the foundation of extending healthspan. Research shows optimistic people live 15% longer than pessimists. A study of 69,744 women and 1,429 men found this connection is scientifically valid: ↓
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I’m buzzing with excitement about the impact of #AI on #biology. @Microsoft and @OpenAI are about to roll out the Stargate system in parts, and honestly, it feels like we’re at the cusp of a whole new era in AI and computational power. This isn’t just another step forward; it’s.
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2. Input → Output OS. Our modern food environment is "immoral". 200,000 years ago, humans had virtually no sugar in their diet. Today, we consume approximately 100 kilograms of sugar annually per person, compared to just a few kilograms 100 years ago, but why?
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.@ericschmidt is always two steps ahead of the curve and able to spot trends coming down the innovation pipeline. this time in the bioeconomy. A year ago he
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I'm on a mission to #BiologizeDavos join our #SyntheticBiology panel tomorrow at 2pm #BiologizeEverything #Davos23 @sean_os1 @GaurabC @rimacha @RChakraba @RyanMorhard Thanks @mark_turrell @unDavosSummit .
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@PeterDiamandis @richroll @PeterDiamandis argues 7-30% of your longevity is determined by genetics. The other 70-93% is within your control through lifestyle. This means your habits have more impact on your longevity than the genes in your body. Here are 5 takeaways I can't stop thinking about:
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In 2019, 180 of the world's most brilliant minds gathered in the Mojave Desert. Whilst Coachella raged nearby. We planned humanities near future on Mars. Here's what we discussed and what this means for the future of humanity: 🧵
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His nutritional advice includes:. • Chewing each bite 20 times.• Eating vegetables first, protein second, carbs last.• Taking a deep breath before eating (activates parasympathetic mode). Following a largely plant-based diet with some fish (Mediterranean approach)
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Got this email from my friend Jim DeKloe: "SynBioBeta always feels like I'm at MacWorld in 1984, it's like everyone there is attending a computer conference right before the internet is about to hit” 🥰.
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I rarely talk about why I love doing what I do as it comes so naturally to me. But it was an honor to speak to @SFBusinessTimes about the love of my life: the synthetic biology community. . @alisha_writes #synbio.
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What are some monopolies that exist in biotechnology? Where does there need to be more competition in the market?.
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My favorite moment of @SynBioBeta was meeting some of the 150 students who came this year 🧬🚀😎 thanks to @ericschmidt, @MaryEMaxon, @SchmidtFutures for the travel grants supporting the next generation of bio talent!
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3. Exercise as medicine. His routine includes 35–40 minutes of daily exercise combining:. • Strength training to maintain muscle mass.• Zone 2 cardio (heart rate around 110 BPM).• High-intensity intervals several times weekly. Here's what he does and its purpose:
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Isn't this animation awesome? It shows what's going on inside every cell in your body right now. If it's foreign to you then come take our interactive synthetic biology course tomorrow in Oakland!
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Wendy Lawton (@wendylawton1), a wonderful mentor of mine in grad school, said that if you wanted your work to be widely read you needed to make sure it contained peanut butter and chocolate. These are two wonderful things on their own, but bring them together and you get
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I’m thrilled to announce the recipients of the 2023 SynBioBeta Global Synthetic Biology Awards, selected by the community in recognition of their outstanding contributions to the field of synthetic biology. Below are this year's honorees:
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What if each protein inside of you was able to talk and tell you the story of its life?.
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‘Ring of Fire’ 🔥? What should we call this awesome image of the synthetic biology companies in the Bay Area? I’ve been thinking it needs to be something more positive and more biological!?
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Cornell Professor Chris Mason (@mason_lab) has a wonderful new book out on engineering life to reach new worlds. He’s doing a fireside chat with NASA Astronaut Kate Rubins (@Astro_Kate7) to kick off #SynBioBeta2024 next week in San Jose and is also hosting a book signing in the
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Congratulations to @stefvangrieken and the Cradle team for raising a $24 million Series A funding round! Cradle's cutting-edge platform uses generative AI and machine learning to accelerate protein design, significantly reducing time and costs in biotech R&D.
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The Synthetic Biology world is full of incredible technologies, visionary companies, profound lessons, & amazing stories that need to be told. Here are 10 women who are telling the fascinating, inspiring, and bold #syntheticbiology stories:.1.
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The #1 rule of #syntheticbiology is don't try to define synthetic biology. But I'd like to break my own rule here and give it a shot. 17 years ago @TomKnightSynBio (left) and @drewendy (right) reviewed an article I wrote . (Photo c/o Wired/Allan Penn/Oliver Morton @Eaterofsun)
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In the new #GrowEverythingPodcast episode, we explore how #biotechnology is merging with other sectors, such as space exploration, and how #syntheticbiology is reshaping the future. We talk about how #biotech can help solve global problems, from environmental to health issues.
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The atmosphere breathed a sigh of relief this week at a half Billion $ investment to suck up CO2 and build things with biology. @LanzaTech can use the power of microbes to turn CO2 emissions from power plants into this dress from @zara. Sounds like science fiction? It’s not. 1/5
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What happens when @bryan_johnson's radical longevity work meets @Jrkelly's cell programming breakthroughs? Find out at #SynBioBeta2025 as we explore synthetic biology as the new OS for human health. Here’s the link to learn more: #SpeakerAnnouncement
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