Journal of Cell Biology
@JCellBiol
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The Journal of Cell Biology (JCB) publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress
New York, NY
Joined September 2009
RT @Schliekerlab: Happy to see this excellent @laemmerdingLab discussion on our @schliekerlab and Mike's @hennelab recent work connecting o….
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RT @HenneLab: Thankful for this writeup in @JCellBiol highlighting work from our group and the @Schliekerlab examining molecular factors th….
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.@JulieHeffler and @LammerdingLab @CornellBME discuss recent studies from the @Schliekerlab ( and @hennelab ( that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum.
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New review: Mellor, Larson, and @DrMengWang discuss the molecular mechanisms of mammalian genomic instability arising from folate deficiency and how this impacts genome biology in health and disease. #CellMetabolism
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Thompson, Stevenson et al @BristolUni show that two cis-Golgi golgins, GMAP210 & Golgin-160, have distinct roles in maintaining #Golgi organization & that both are required to support the efficient secretion, assembly, and modification of ECM proteins
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The Tu lab show that a polymorphism in the Mkt1 gene underlies complex genetic phenotypes among strains of budding yeast. Mkt1 interacts w/ a #StressGranule protein Pbp1 to regulate expression of mitochondrial proteins, TORC1 signaling & autophagy in yeast
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Narozna et al. uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate
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With a combination of FIB-SEM, super-resolution & expansion #microscopy, Araujo Alves, Bastin et al. reveal how IFT trains are progressively restricted to a limited number of #microtubule doublets in the flagellum of T. brucei.
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RT @shoemaker_lab: The secret life of LIRs: Binding to Atg8-family proteins is just a fraction of what LIRs can do. .
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Geng, Verhey et al find that KIF1C forms condensates where the exposed #kinesin motor domains entangle nearby #microtubules, causing them to bend & break in a process dependent on motor processivity, cluster properties, cytoplasmic viscosity, & MT anchors
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Hawkins, Fernandez-Gonzalez et al. @UofT introduce ReSCU-Nets, recurrent neural networks for integrated segmentation and tracking of three-dimensional #microscopy images.
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Spotlight: Needhi Bhalla highlights work from Narula and Wignall ( that describes an unexpected, noncanonical role for PLK-1 in the suppression of #centrosome maturation during #meiosis. #Celegans #Genetics.
rupress.org
Narula and Wignall combine high-resolution imaging with auxin-inducible degradation to demonstrate that PLK-1 suppresses centrosome maturation and dampens
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Minami Hasegawa-Ogawa, Hirotaka James Okano et al. identify a dominant-negative TDP-43 isoform regulated by #ALS-linked #RNA-binding proteins. hnRNP K promotes its expression, while hnRNP A1 and FUS suppress it. #Disease #Neuroscience #RNAbiology
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Zheng et al. @SUSTechSZ reveal that during starvation, SOD1, linked to #ALS, is transported into #lysosomes through #autophagy and the receptor protein TP53INP1. Within lysosomes, SOD1 regulates ROS levels and safeguards lysosomal activity and integrity.
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Kenworthy et al @MedicineUVA explore the evolutionary history of caveolins. Using computational predictions & #CryoEM, the authors show both animal & choanoflagellate caveolins assemble into amphipathic disks composed of seven conserved structural elements
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Arc spreads Crumbs: Spatial restriction of tissue invagination to form a thin epithelial tube. Tony Harris spotlights new work ( from Ji Hoon Kim, Deborah Andrew et al.: #Drosophila #Development
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AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact. @BenjaminPadman et al @LazarouLab outline a segmentation strategy for 3D FIB-SEM data from cells #Biophysics #Mitochondria #Organelles
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Our August issue is here! Cover shows confocal🔬image of a #Xenopus laevis zygote in metaphase of the first embryonic #mitosis stained by immunofluorescence to visualize spindle. #Microtubules (magenta), DNA (cyan). Cantwell et al.
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Tony Harris spotlights work from Kim et al. (, which identifies an inhibitory pathway that controls the formation of epithelial tubes during #Drosophila salivary gland #development:
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Scientist-philosopher & former @JExpMed editor René Dubos is the focus of a new e-book from @RockefellerUniv. The annotated bibliography by Carol Moberg covers his ideas on health, society, ecology, and humanity, all strikingly relevant today. More here:
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