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Iris Simón Sáez Profile
Iris Simón Sáez

@irisdobles

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Postdoctoral Fellow on Prostate Cancer & CIN- Biochemistry & Mol. Biology - Mayo Clinic. From Orihuela, Spain.

Rochester, MN
Joined March 2020
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@Nature
nature
1 month
People being treated for certain deadly cancers lived longer if they had received an mRNA-based vaccine against COVID-19 than if they hadn’t https://t.co/ZR3tYeHElg
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nature.com
Nature - mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
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@MayoCancerCare
Mayo Clinic Comprehensive Cancer Center
1 month
Hope is on the horizon for advanced #prostatecancer thanks to a study led by molecular biologist Dr. Veronica Rodriguez-Bravo. The study uncovers how prostate cancer exploits a protein in order to resist targeted therapies and evade the immune system. https://t.co/m7zy08ada8
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newsnetwork.mayoclinic.org
Mayo Clinic uncovers hidden driver fueling aggressive prostate cancer. Learn more about the latest research.
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@GeneHumdi
Cost Action GenE-Humdi
2 months
On behalf of @genehumdi member @gmnavajas 🚨Looking for a #GeneEditing #Postdoc at @sangerinstitute ! Cutting Edge Science: ✂️CRISPR/Cas9 Editing 🔬small molecule screenings 🧫single-cell genomics 👩‍🔬 functional analyses Learn more: https://t.co/JUc6nNObmu
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@davidlandeira
David Landeira
3 months
Thrilled to share our story in its final form! https://t.co/cCr9a1kpoO💥 After ~10 years, we show that BMAL1 represses transposons via chromatin regulation in embryonic stem cells—rather than circadian rhythms as in adult tissues.
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nature.com
Nature Communications - Here, the authors find that BMAL1, best known for controlling the body clock, partners with TRIM28 in naïve pluripotent stem cells to repress retrotransposons.
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@simonmaechling
Simon Maechling
4 months
RFK Jr. just cut $500 million in federal funding for mRNA vaccine development. Not because the vaccines failed. Not because they’re unsafe. But because of ideology. Twenty-two projects - gone overnight. These weren’t fringe efforts. They included next-gen vaccines for COVID-19,
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@mayoclinicbmb
MayoClinicBMB
4 months
Thanks to the organizers, guests & participants of the 2025 Ehlers Symposium for an energizing scientific retreat.
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@irisdobles
Iris Simón Sáez
4 months
Congratulations to my colleagues for their amazing last paper on the role of nucleoporins in #prostatecancer progression and immune evasion!! @VRodriguezBravo @DomingoDomenech
@ElizSMcKenna
Elizabeth McKenna
4 months
Now in @CD_AACR: Off-Pore Nucleoporin sPOM121 Propels β-Catenin-Driven Tumor Progression & Immune Escape in Prostate Cancer - by Perumalraja Kirthika, Vijayakumar Jawalagatti, Peiyao Li, @shijiazhu02 @VRodriguezBravo @DomingoDomenech et al. https://t.co/rwFAC4Yw2g
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@MayoUrology
Mayo Clinic Urology
4 months
Congrats on @MayoUrology published study led by Drs @VRodriguezBravo and @DomingoDomenech discover that nucleoplasm-residing nucleoporins drive #ProstateCancer progression & immune evasion by switching on oncogenic signaling from deep within the nucleus! https://t.co/99Kmakz161
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@irisdobles
Iris Simón Sáez
5 months
In this paper we show that resistance to Apalutamide is driven by AR bypass and tumor plasticity, not classic AR variants. Thanks to all who were part of this! #prostatecancer #CancerResearch #CRPC #Oncology
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@irisdobles
Iris Simón Sáez
5 months
I'm thrilled to share the publication of our paper: "Phenotypic Plasticity and Androgen Receptor Bypass Drive Cross-Resistance to Apalutamide in Castration-Resistant Prostate Cancer Cell Models" Part of my PhD work at @genyo_pts !
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mdpi.com
The treatment of choice for prostate cancer is androgen deprivation (ADT) and novel hormonal agents such as Abiraterone, Enzalutamide, or Apalutamide. Initially, this therapy is highly effective, but...
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@genyo_pts
GENYO
6 months
#PublicaciónCientífica “Oncogenic KRASG12D Transfer from Platelet-like Particles Enhances Proliferation and Survival in Non-Small Cell Lung Cancer Cells” @CanalUGR @ibsGRANADA @FacMedicinaUGR @hospital_hvn https://t.co/cDjl3yc9FL
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@CD_AACR
Cancer Discovery
7 months
News: NIH Could See Funding Slashed by 40% https://t.co/VRhps6Fzcd
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@bitacorabeagle
Julio Rodríguez, PhD | Genética Clínica
9 months
Logran eliminar el cromosoma extra del síndrome de Down Utilizando la técnica de edición genética CRISPR-Cas9 en células madre pluripotentes in vitro logran pasar de 3 a 2 cromosomas 21. Este es un avance significativo en el campo de la medicina genómica https://t.co/8YrecO8nFZ
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@Fundpfizer_ES
Fundación Pfizer ESP
9 months
👩‍🔬Seguimos celebrando el #DíadelaMujerylaNiñaenlaCiencia Hoy, en el IES Ágora de Alcobendas con estudiantes de 1º Bachillerato. En la clase de #biología han visto la docuficción ‘Ciencia para Vivirla’ protagonizada por @irisdobles Gracias al instituto por su implicación ♥ #STEM
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@Fundpfizer_ES
Fundación Pfizer ESP
10 months
🔬Estamos en @genyo_pts celebrando el #DíadelaMujerylaNiñaenlaCiencia con estudiantes de la ESO del IES Padre Manjón de Granada Tras visitar el centro: ✅Han visto ‘Ciencia para Vivirla’ https://t.co/Ql919Umy0b ✅Han interactuado con su protagonista, la investigadora @irisdobles
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@Fundpfizer_ES
Fundación Pfizer ESP
10 months
#STEM | 👧👩‍🔬El #11F celebramos el #DíaMujeryNiñaCiencia en el @genyo_pts. Alumnos de 1º, 2º y 3º de la ESO del IES Padre Manjón de Granada visitarán el centro 🔬🧪, visionarán la docuficción ‘#Ciencia para Vivirla’ 📹 y conocerán a su protagonista, la investigadora @irisdobles
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@genyo_pts
GENYO
10 months
¡El 11 de febrero celebramos el #diadelaniñaylamujerenlaciencia en GENyO! Los alumnos del IES Padre Manjón tendrán la oportunidad de ver la docuficción “Ciencia para vivirla” que realiza la @fundacionPfizer podrán conocer a su protagonista @irisdobles.
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@InsiderWorld_1
The Palestinian
1 year
All eyes on #Rafah 🇵🇸
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@tweet_Javi
F. Javier Molina E.
1 year
🧬Congrats to the @karim_benabdel team and specially to 👩‍🔬#KrisPavlovic for devoting such effort to better comprehend how to improve CAR-T therapies. The paper "Generating universal anti-CD19 CAR T cells with a defined memory phenotype..." is now online! https://t.co/QEvgTUgWja
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frontiersin.org
IntroductionChimeric antigen receptor-expressing T cells (CAR T cells) have revolutionized cancer treatment, particularly in B cell malignancies. However, th...
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