Luke Pattison
@interlukein
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Research scientist interested in inflammatory pain 🔬 👨🏼🔬 ✌🏼
Cambridge, England
Joined November 2016
Hooray!! The first major product from the lab is out today @Nature. Small molecules that bind the GPCR-transducer interface change G protein subtype selectivity in predictable ways, enabling rational drug design.💥 Check it out! 👉 https://t.co/oO21BkoxVQ 🧵👇
nature.com
Nature - Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching...
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Great summary of our latest work - a real Team Science effort! 👥 🐭
The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid during OA. This study shows that SM34:1 causes inflammatory pain in mice and induces neuronal hyperexcitability. Great work: @psalmotoxin @interlukein @mayadannawi @LanhuiQiu @BeckyRickman @UnivCamPharm
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I am currently curating a Special Issue for @Cells_MDPI on “Molecular Mechanisms Underlying Inflammatory Pain.” If you are working on, or planning a suitable manuscript, I would be delighted if you would consider submitting it to our issue. https://t.co/SAKZRNuqLH
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Proud to watch my Pegasus Scholars students presenting on targeted cancer therapies today, after a week exploring the formation, functions, faults and fixing of proteins! 🔬 Glad to support Robinson College’s excellent widening participation initiation for another year! 👨🏫
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An inspiring week of meetings! 💡 @CamNeuro symposium and the inaugural meeting of the GPCR-UK network! Stepping into the lab with fresh enthusiasm this morning!!
A couple of days of neuroscience excellence at the 8th @CamNeuro Symposium: Interventions & Recovery. So many great talks, loads of representation from our lab showcasing what everyone has been up to, & insightful public panel discussion on dementia!
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If you have #osteoarthritis which causes you #pain, please consider answering my 2 minute survey below 👇
👋I’m developing a proposal to investigate how pain changes with progression of osteoarthritis (OA). 🦴⚡️ If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏 https://t.co/UGzTw3krCm
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👋I’m developing a proposal to investigate how pain changes with progression of osteoarthritis (OA). 🦴⚡️ If you have OA, I’d love to hear how your experience with pain has changed over time - please consider answering this quick 10-question survey! 🙏 https://t.co/UGzTw3krCm
forms.office.com
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https://t.co/yASiWdl5ET New preprint from the lab: Targeting piezo2 to treat osteoarthritis pain
biorxiv.org
Musculoskeletal pain is a significant burden affecting billions of people with little progress in the development of pharmaceutical pain relief options. The mechanically-activated ion channel Piezo2...
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📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia! 🧠 Interested in presenting at #SfN25 in San Diego in November? 🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal! #PainResearch #Neuroscience
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📣 Calling fellow ECRs studying the contributions of GPCRs to pain and/or analgesia! 🧠 Interested in presenting at #SfN25 in San Diego in November? 🙏 Please drop me a message - looking for last few speakers for a mini symposium proposal! #PainResearch #Neuroscience
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Exciting project, great mentor, lovely Cambridge - get applying!
🚨 Excited to announce that we are hiring 🚨 If bowel disease, pain, & naked mole-rats are your thing then we have the perfect opportunity for you 😃 This @ChatGPTapp image shows a naked mole-rat with visceral pain, but they actually appear resistant #PainResearch
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Research Showcase of our latest work investigating the role of acid-sensitive receptors in inflammatory joint pain! 💊 https://t.co/quL5v73hOP
growkudos.com
Inflammation is often linked to increased acidity in tissues, which can activate specific receptors such as GPR65. In this study, we found that activation of GPR65 in cells lining the knee joints of...
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@PNASNews Special thank you to @mayadannawi for supporting revision experiments! 🙌🙌🙌
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Very happy to share the published version of this work - out now in @PNASNews - riding the year out on a high! ✨ https://t.co/eLV2N4ztKg More on this work below 👇
pnas.org
Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is chal...
Very happy to share our ✨ NEW ✨ preprint! Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory pain. https://t.co/3oDoh36aVL Keep reading for a summary of what we found… 🧵[1/10]
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Excellent tweetorial describing our latest work, looking at lipids and inflammatory joint pain 👇
Pain = main driver of clinical decision making in osteoarthritis (OA). Our lab studies OA pain mechanisms. During OA, multiple cell-cell interactions occur, many mediators being released that alter the contents of the synovial fluid. #neuroscience #pain
https://t.co/CbUGmrjTy2
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Through #PainAwarenessMonth we are collecting the 3-words that best describe your pain and creating a word cloud of them all. If you want to be involved, share your 3-words here: https://t.co/rzWZMoOi8g
#My3Words #ChronicPain
@UoDMedicine @HDR_UK @MsApdp
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Are you living with #ChronicPain? Have 15 minutes to spare? Please consider completing the UK National Pain Survey? Get your voice heard and shape the future of pain research! 🙏
Alleviate & partners @ChronicPainAust @Pain_UK @MsApdp launch 2nd UK National Pain Survey! Share your lived experiences of chronic pain & help inform research. Complete the survey today: https://t.co/sX4WZ7YWDS
#PainSurvey2024 #PainResearch #YourVoice
@UoDMedicine @HDR_UK
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@interlukein et al. find that deficits in mouse digging behaviors resulting from pain models correspond well with how humans experience pain and hold value in preclinical testing of analgesics. Learn more in #PAIN
https://t.co/zIhKHC6fGM
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