Holger Dannenberg
@hdannenb
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Neuroscientist investigating septo-hippocampal functions in memory; Assistant Professor in the Dept. of Bioengineering at George Mason University. he/him
Joined September 2016
Excited to see this work published in @eLife
https://t.co/LgDDTS8RnX We provide a mathematical proof that grid cells are the only possible way the brain can code for spatial trajectories using cell sequences, when the code shall be valid across environments!
elifesciences.org
The characteristic hexagonal firing pattern of grid cells emerges as the most parsimonious solution to a trajectory code by cell sequences.
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Cholinergic modulation of exploration in rats performing a spatial memory task https://t.co/DL6YOkNJsG
#biorxiv_neursci
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Our new paper is out. About hippocampal phase/rate information processing with inhibitory microcircuits in dentate gyrus. With Barış Kuru @oliver_braganza @HeinzBeck8
nature.com
Nature Communications - How neural codes are passed from one brain area to the next remains poorly understood. Here, the authors show how neuronal feedback inhibition converts incoming temporal...
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Acetylcholine modulates the temporal dynamics of human theta oscillations during memory https://t.co/Yo1ukroFEG
#neuroscience
nature.com
Nature Communications - Memory loss is a known result of cholinergic dysfunction, yet the neural basis for this effect remains unknown. Here, the authors demonstrate that the way cholinergic...
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I was watching Lord of the Rings last night and realized there are many parallels with academia! A thread 🧵👇
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We argue the global geometrical organization in grid maps is a direct consequence of a simple local sequence code using a finite number of neurons. Trajectory coding by grid cell sequences provides intuitive explanations for many puzzling experimental observations.
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Ever wondered how a single grid cell "knows" when or where it is supposed to fire again?
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This theory provides a simple and intuitive explanation of spatial periodicity in grid cell firing. Moreover, this theory provides a mechanistic explanation for how grid cells perform path integration.
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We provide mathematical proof that spatial periodicity in grid cell firing is the only possible solution to a neural sequence code of 2D trajectories. We thus provide a teleological cause for the existence of grid cells, namely sequence coding of trajectories.
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The beautiful and enigmatic spatial periodicity in the firing pattern of grid cells continues to inspire neuroscientists. But why has this hexagonal firing pattern evolved in the brain of mammals? What is it good for? Why not something else instead?
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Spatial periodicity in grid cell firing is explained by a neural sequence code of 2D trajectories https://t.co/HY3dn2KcjO Thank you to Rebecca R.G. and Giorgio Ascoli for a fantastic collaboration!
biorxiv.org
Spatial periodicity in grid cell firing has been interpreted as a neural metric for space providing animals with a coordinate system in navigating physical and mental spaces. However, the specific...
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The DataWorks! Prize rewards teams whose research demonstrates the power of data sharing and reuse to advance scientific discovery and human health. https://t.co/Z9UcYMspQZ has been selected as one of the finalists, please support us by voting for us: https://t.co/MxLoyGYZPz
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Theoretical physics relies on equations you can take literally. This paper, with @RuiiiChaos, Jay Bladon, Steve Charczynski, @HasselmoMichael, works towards an eq for the brain you could take literally. https://t.co/sv3W5k3CdF
biorxiv.org
The Weber-Fechner law proposes that our perceived sensory input increases with physical input on a logarithmic scale. Hippocampal “time cells” carry a record of recent experience by firing sequenti...
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Curious about temporal dynamics of cholinergic activity in the septo-hippocampal system? Read our lab's first paper: https://t.co/CGBuG59sTI Many thanks to all authors and funding agencies! Stay tuned for more! Also, we can fund two post-doc positions. Please DM if interested.
frontiersin.org
Cholinergic projection neurons in the medial septum and diagonal band of Broca are the major source of cholinergic modulation of hippocampal circuit function...
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Great research, great people, great place, great opportunity!
Adrien Peyrache @apeyrache and I are looking to hire a co-supervised postdoc to develop next-gen miniscope imaging to study the HD system. Please DM if interested.
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If you're almost done with your PhD and are interested in developing new (super cool) techs in neuroscience, DM @markpaulbrandon or me. I'm at #FENS2022 if you'd like to meet in-person.
Adrien Peyrache @apeyrache and I are looking to hire a co-supervised postdoc to develop next-gen miniscope imaging to study the HD system. Please DM if interested.
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We are hiring! See official ad below for two positions as Postdoctoral Research Fellow https://t.co/y1jI8V6pgt via @washpostjobs
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(5) Kudos to the authors @jeffrey_kopsick, Kyle Hartzell, Hallie Lazaro, Pranav Nambiar, and @HasselmoMichael
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