Heike Brötz-Oesterhelt
@hbroetz
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Prof. of Microbiol. @ Tuebingen, previously @ Duesseldorf; before that 12 yrs in industry (Bayer HealthCare, AiCuris); dedicated to antibiotic modes of action
Univ. of Tuebingen, Germany
Joined October 2019
Great consortium! Looking very much forward to our joint research.
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Happy to report on epifadin, a new bacteriocin shaping the human microbiome. New structural class, very short lived. Kills S. aureus rapidly and gives the producer S. epidermidis a profound advantage. Thanks to the teams of Peschel, Krismer, Grond.
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We are happy to share our new paper on the uptake of fosfomycin through porins of E. coli. Our data show that the cytoplasmic membrane is the rate-limiting barrier, unless the relevant transporters are induced. Thanks to @TRR261 and @CoE_CMFI and the team.
pubs.acs.org
The antibiotic fosfomycin (FOS) is widely recognized for the treatment of lower urinary tract infections with Escherichia coli and has lately gained importance as a therapeutic option to combat...
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Happy to share our brandnew paper on the first natural product beta-lactone ClpP inhibitors. They bind covalently, inhibit virulence and gave beautiful co-crystal structures with ClpPs from all three domains of life. Thanks Groll, Kaysser, Sieber, Grond labs for excellent work !!.
Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A (Heike Broetz-Oesterhelt and co-workers) @hbroetz @TTR261 @CoE_CMFI #openaccess thanks to #projektDEAL
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Job opening in my team!! Position for a PhD candidate in a soon to start Marie-Curie European Traning Network on cell envelope active antbiotics. Mode of action studies on new antibacterial agents. Please look at the attachement and spread the word. Thank you.
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". the “pandemic treaty” must . respond to a wider range of pandemic threats, not solely viruses . If governments are serious about pandemic preparedness, they must support bold measures to conserve the effectiveness of antimicrobials within the Pandemic Instrument.".
Removing antimicrobial resistance from the WHO’s ‘pandemic treaty’ will leave humanity extremely vulnerable to future pandemics
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Dear Colleagues and friends . thanks so much for making this event unforgetable.
Our CellMAP Conference was very successful. We enjoyed the excellent talks and posters, great science and unforgettable networking! We would like to thank all participants for the amazing atmosphere! Thank you for being there!
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I am getting excited . less than six weeks ahead . .
Our CellMAP conference is filling up. Are you still undecided? Now is the time to secure your seat!! A diverse international crowd has registered already. We also offer child support — a great opportunity for scientific dual-career couples.
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Two PhD positons available in our team!!! Antibiotic MoA studies, including work on the fascinating target ClpP protase. One position within the Cluster of excellence CMFI the second within the European Training Network CLEAR 'Cell Envelope Antibiotics'.
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New paper with Peter Sass and Scott Ouellette. Chlamydial AAA+ unfoldase ClpC, its functional reconstitution, characterization, individually and in the ClpCP2P1 protease. Essential role for ClpC in chlamydial growth and intracellular development.
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Organized by the TRR261, this conference is open to the entire natural products and antibiotics community!!! Antibiotic Action and Antibiotic Biosynthesis together in the same conference. This is rare but generates a lot of synergy. Register today as seats are filling rapidly !!.
Have you already registered to our CellMAP conference? This is a unique opportunity to meet prestigious scientists who are the elite in antibiotic research and excellent chance to present your own scientific results and to make new contacts. Register today!
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All the best for your start, Simon.
This is such a special day. I am really excited about new tasks and opportunities in the coming years.
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RT @NobelPrize: Happy International Women's Day!. We're celebrating women who have changed the world. Here's all of the amazing women who h….
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Happy women's day, today.
The first woman to be awarded a Nobel Prize, the first individual to be awarded two Nobel Prizes and still today the only individual with two Nobel Prizes in two different scientific categories: Marie Skłodowska Curie. Learn more:
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Dear community, the TRR261 conference is open to interested members of the international antibiotics and natural product community. We are happy that so many excellent speakers have followed our invitation. Registration portal will open soon. Check out under //trr261/news.
We are happy to announce that our International CellMAP Conference will take place in Bad Boll, on 22-25 May, 2023.
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RT @saveantibiotics: Of the 45 antibiotic candidates in global clinical development, just 27 target @WHO priority pathogens. .
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Congratulations Lisa. Very much deserved.
Very honored to be among this year's #ERC_StG awardees! The grant will allow us to study microbiome-mediated effects of psychotropic drugs. A big thank you to all lab members, collaborators, mentors, friends & family for their continued support.@ERC_Research @CoE_CMFI @uni_tue.
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RT @CoE_CMFI: Interesting insight into research conducted by @TBoettcher_Lab and team on chemical interactions in the microbial world!. Tha….
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