🚨🚨I am excited to share that my PhD work is now published in @emboreports! 🎉 We uncovered the role of novel SCAR-6 elncRNA locus in coagulation and vascular function. https://t.co/iNenG0Dkdb ♥️🐟🩸

Wow! NanoBanana Pro is incredible! This is a perfect cartoon depicting the activation of a T cell with the full signaling cascade! I only asked it to draw the interaction & show the signaling & it figured out the rest! I am declaring that image-level AGI has now been achieved!

Excited to present the first major work after starting our lab at Stanford and the Arc this year: CRISPR-All, a unified genetic perturbation language for programming any major type of genetic perturbation simultaneously, in any combination, at genome scale, in human cells.

Our PLAMseq paper is out today in @ScienceAdvances . We developed a TurboID-based protein-genomic approach to map proteins and protein interactions in the genome. Validated with CTCF and RNApolII. Applied to map Histone H1 SUMOylation genomic loci. https://t.co/7wDxkMLt2E

After two years of work, we’ve made an AI Scientist that runs for days and makes genuine discoveries. Working with external collaborators, we report seven externally validated discoveries across multiple fields. It is available right now for anyone to use. 1/5

The functional impact of 17,000 (!) missense LDLR variants on LDLR cell-surface abundance and LDL uptake and their effects on hyperlipidemia phenotypes @ScienceMagazine

New Roche sequencer being tested for same-day genome interpretation in neonatal ICUs: "In the case of blood samples that arrived at the laboratory by 7 a.m., we obtained an interpreted report between 2 p.m. and 4:30 p.m. the same day." https://t.co/1wt1Z10QjH

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! https://t.co/J5HekY1Pc0

Grateful to be part of this exciting study and collaborate with a fantastic team of @MotianiRaj1 lab in exploring the interconnected roles of ORAI3, NFATc1, and MARCH8 in understanding of cancer biology. #CancerResearch #zebrafish

Latest genomic AI models report near-perfect prediction of pathogenic variants (e.g. AUROC>0.97 for Evo2). We ran extensive independent evals and found these figures are true, but very misleading. A breakdown of our new preprint: 🧵

Some mitochondria puff out their content into the cytoplasm, exhibiting localized membrane distentions. This may contribute to inflammatory responses, for examples.

I am always amazed by the diversity of wrong ideas clinicians have about #VUS Today's one is unique- a clinician (a senior one) telling me that VUS is a low quality variant , and is there in the report because it was possibly not covered deep enough. #MedTwitter #genetics 1/3

Principal Investigator Joshua Mendell (@Mendell_lab) and researchers at @UTSWMedCenter highlight the functional versatility of snoRNA sequences and expand the known mechanisms through which noncoding RNAs orchestrate ribosome biogenesis.

First, Google DeepMind put structural biologists out of work, and now it's coming for the jobs of bioinformaticians doing genome analysis: a preprint reveals AlphaGenome, the little brother of AlphaFold.

Perturb-seq enables analyses of the single-cell transcriptomic underpinnings of gene knockouts❗️ X-Atlas/Orion is a publicly available dataset that scales perturb-seq to unprecedented levels👇 [1/4]

It’s a wrap! Big thanks to all the speakers and attendees for sharing great science and vibrant networking at the Finnish Society of Atherosclerosis meeting during the last two days. See you next year in Turku, June 11–12, 2026! 🇫🇮🫀 #Atherosclerosis

I'm co-Guest Editing a special Collection in @GenomeMedicine with @clintomics and we warmly invite you to submit your work! From #multiomics & #AI to #regenerative medicine - this Collection focuses on decoding #CardiometabolicDisease @https://biomedcentral.com/collections/5203

Sharing our new paper on rare damaging CCR2 variants that we found to be associated with protection against atherosclerotic cardiovascular disease🧬🫀❗️ A short thread about the topline findings🧵

Our paper "Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function" is now published in @NAR_Open https://t.co/o3WSUnksBv. This work was led by our super postdoc @ShengJiaLin9413 * Several papers on F0 mutagenesis have been

🚨📰TWEETORIAL time📰🚨 Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR mutagenesis of the MYC TAD (~3 Mb) in 6 different human cancer cell lines https://t.co/jlOwovgYaL

If you want to explore your favorite mitochondrial gene, function, or pathway in different human tissues and organs, have a look at the first version of https://t.co/KunIRe7DzP Feedback welcome!