
Eray Enustun, Ph.D.
@EnustunEray
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PhD from @ucsdbiosciences ‘23 - B.S. in ChemEng and B.S. in Mol Biology&Genetics @kocuniversity ‘16, MSc. @kocuniversity ‘18
San Diego, CA
Joined November 2019
My second “first author” paper is published by Nucleic Acids Research! We show how one of the proteins I found from the proteomics screen (Enustun et al., Nat Struct Mol Biol, 2023) is important for mRNA transfer from the phage nucleus and for their translation.
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One of the best works I contributed led by one of the best scientists I know @iamamardeeep & @_KevinCorbett lab. Check out the amazing paper that explores molecular mechanism of PARIS immune system!.
Out today in @Nature! .I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett @_KevinCorbett, and my teammates. See the thread below in comment section for a quick summary!.
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@Emy_nim @jina_leemon @ben_a_adler @bradyfcress Finally, I would like to thank my PIs @_KevinCorbett & Dr. Joe Pogliano for the guidance and their supports. I would like to acknowledge NIH & HHMI for their funding. I couldn't do this work without my labmates and collaborators mentioned above (+ @iamamardeeep & Yajie Gu). n/n.
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@Emy_nim @jina_leemon @ben_a_adler @bradyfcress Relatedly, LC-MS/MS showed ChmC knockdown causes a global reduction in phage protein and effects more present for the putative virion structural proteins. We believe this is due to ChmC's role in the stages of infection where transcription occurs in the phage nucleus. 8/n
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@Emy_nim @jina_leemon @ben_a_adler @bradyfcress To test our hypothesis if ChmC is responsible for transfer of the mRNA from the phage nucleus to cytoplasm, we performed mRNA-FISH (with which showed accumulation of the mRNAs of virion structural proteins in the phage nucleus. 7/n
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To investigate further in vivo, we (@Emy_nim & @jina_leemon) collaborated with Nobel laureate Dr. Jennifer Doudna's team (@ben_a_adler @bradyfcress) and used their new CRISPR-iART. Knockdown of ChmC during infection impairs phage nucleus development and halts infection. 6/n
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I’m not saying this because I am a part of this work, but this is an amazing work! . Led by amazingly smart & talented @iamamardeeep.
In this bioRxiv preprint, we (@_KevinCorbett ) present the architecture and activation mechanism of the PARIS antiviral defense system. Thanks to our co-authors, @Lisa_Liang13, @EnustunEray, and @PoglianoJoe, for their support in shedding light on this Anti-anti-defense system.🧵
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RT @justinrmeyer: Our newest paper was published today, a capstone to our work on gain-of-function evolution, phage-bacterial interaction n….
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RT @_KevinCorbett: I'm thrilled to share the latest work from my lab, showing that a bacterial anti-phage immune system encodes a ubiquitin….
biorxiv.org
Ubiquitination and related pathways play crucial roles in protein homeostasis, signaling, and innate immunity[1][1]-[3][2]. In these pathways, an enzymatic cascade of E1, E2, and E3 proteins conjug...
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RT @ben_a_adler: Fascinating biology on how the phage nucleus translocates its RNA!. For a deep dive, check out @EnustunEray 's thread 👇.
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Finally, special shoutouts to my amazing collaborators: @Emy_nim , @jina_leemon , @iamamardeeep , @thevillalab, @doudna_lab , @yeo_lab.Sitao Zhang (Cleveland lab) & all of my past and current labmates from Pogliano lab and Corbett lab! Thank you all!!.
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