Dina Simkin
@dsim9
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Fixer of things, Electrophysiologist, Ion channel enthusiast
Chicago, IL
Joined May 2014
RT @Kcnq2Cure: The 2023 KCNQ2 CURE SUMMIT will bring together an outstanding community of researchers, clinicians, and families to advance….
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RT @MarcForrest7: Very proud to announce my work on the 16p11.2 duplication mouse model is now published!! It’s been a looong journey with….
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Just submitted my first R01 research grant on exploring #HomeostaticPlasticity in #iPSC models of #DevelopmentalEpilepsy! #KCNQ2 #ionchannels!.
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This is a really great study out of Peter #Penzeslab using iPSC-derived excitatory and inhibitory neurons to model schizophrenia. One of the first publications to implement the iGABA differentiation method (Yang et al. 2017).
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RT @TrendsinPharma: ‘Channeling’ therapeutic discovery for epileptic encephalopathy through iPSC technologies, online now, review article f….
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‘Channeling’ therapeutic discovery for epileptic encephalopathy through iPSC technologies - ScienceDirect
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RT @ScienceCrisp: "Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standa….
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Depolarizing GABAA current in the prefrontal cortex is linked with cognitive impairment in a mouse model relevant for schizophrenia | Science Advances
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RT @ChicagoSfN: Mark your calendar 📅 for the @ChicagoSfN meeting on April 8-9! Outstanding speakers to come!👇.We are accepting submissions….
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Untangling Cellular Changes in Pediatric Epilepsy
news.feinberg.northwestern.edu
For the first time, Northwestern Medicine scientists have characterized how a genetic mutation associated with pediatric epilepsy affects neuron activity.
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RT @axionbio1: Researchers @NorthwesternU used the #MaestroPro MEA system to study an #iPSC model of neonatal epileptic encephalopathy. The….
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Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy | eLife
elifesciences.org
An inducedpluripotent stem cell (iPSC)-based model of KCNQ2-associated developmental epileptic encephalopathy suggests that disease is driven by dyshomeostaic neuronal mechanisms that are downstream...
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RT @CellCellPress: New Article now online: KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies
cell.com
KCNE1, a β-subunit of the cardiac KCNQ1 channel belonging to the voltage-dependent channel superfamily, serves also as an auxiliary subunit of the anoctamin superfamily member TMEM16A, a calcium-ac...
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RT @Hbhayes4: Great Maestro data from the Kiskinis lab at Northwestern. #AxionBioSystems #Maestro #epilepsy
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RT @Channelopath_18: Dear ion channels aficionados - Here we are! The provisional program of #channelopathy2018 meeting is online - check h….
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