Jonathan Rogers
@drjprogers
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Clinical lecturer in psychiatry. Neuropsychiatry researcher. Catatonia, movement disorders, neuroimmunology, psychopharm & epidemiology. Christian. Views my own
London, England
Joined December 2019
📢Our new British Association for Psychopharmacology guidelines on CATATONIA are now out!📢 💠22 experts 💠3 continents 💠>500 references Read the full #OpenAccess guideline here: https://t.co/7w5b211JkQ.
@BAPsych #catatonia
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Might be of interest to @global_gng, @The_BNPA, @SecretaryINA. This paper really makes the case for neuropsychiatry!
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Read the paper to learn more. Thanks again to @ella_burchill for leading this and great collaborators in @NaomiLaunders, @GlynLewis9, @ProfTonyDavid, Joe Hayes & David Osborn. @UCLPsychiatry @UCLBrainScience
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There's loads more you could discuss with these graphs... What are the differences between SZ, BPAD and other psychoses? What direction(s) might the causation be in?
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Dementia is another interesting graph. Here you can see that dementia cases become much commoner in the year or few after you have psychosis.
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The same is true for Parkinson's disease, but the graph looks completely different. It seems like there is loads of Parkinson's in years before an 'other psychosis' diagnosis.
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Let's take ataxia, for example. You can see that schizophrenia, bipolar disorder and other psychoses are all more common in those with ataxia.
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I think that's really big news. It's not just the usual culprits of epilepsy and Parkinson's: it is just about every neurological condition.
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Out of the 15 neuro conditions we looked at, 13 were more common in the SMI group. That's MS, cerebrovasc disease, dementia, ataxia, epilepsy, Parkinson’s, other parkinsonism, paralysis, other movement dis, CSF disorders, CP, peripheral nerve disorders & autonomic disorders.
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We used UK primary care data to identify 68,789 patients with SMI and compared them to a matched group of 274,827 patients. We examined how common various neuro conditions were in the years before and after an SMI diagnosis, compared to those without SMI.
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Thanks to work by @NaomiLaunders, we already know that neurological conditions as a whole are overrepresented in people with severe mental illness (SMI). But which neurological conditions? And which comes first - the neuro condition or SMI?
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Neuropsychiatry is plagued by small sample sizes. @ella_burchill is changing this with a BIG new paper on the relationship between psychosis and 15 neurological conditions in @BMJMentalHealth. https://t.co/nLrrrF3Bx9 Here are some highlights...
mentalhealth.bmj.com
Background A higher prevalence of neurological conditions has been found in schizophrenia, bipolar disorder and other psychotic illnesses compared to the general population. We aimed to understand...
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📣 Proud to share our CPRD project examining the temporal relationship between severe mental illness and neurological conditions is published @BMJMentalHealth
https://t.co/YjLJw4gXJi
@drjprogers @NaomiLaunders @GlynLewis9 @ProfTonyDavid Joe Hayes David Osborn @UCLPsychiatry
mentalhealth.bmj.com
Background A higher prevalence of neurological conditions has been found in schizophrenia, bipolar disorder and other psychotic illnesses compared to the general population. We aimed to understand...
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ECT really does save lives. Our new SR/MA shows reduced mortality with ECT v comparator treatments. No reduction in suicides, but you probably wouldn't expect to be able to show that. Great work from Hamish Naismith's PhD.
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Our new systematic review of the recent literature on ADHD meds in pregnancy published in @AWMH_Journal. TLDR: probably best to stop modafinil if considering pregnancy. Thanks to Sarah Tai for leading this! https://t.co/8bCygGhgfz
link.springer.com
Archives of Women's Mental Health - During pregnancy, it is unclear whether women with attention deficit hyperactivity disorder (ADHD) should stop prescribed medication – risking relapse...
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Exciting development in the catatonia world! With @catatoniafdn, we have made a data dictionary of 13 different catatonia datasets! If you have a research Q and no data, or you have data and want to demonstrate external validity, have a look here: https://t.co/BJdFvOCET6.
thecatatoniafoundation.org
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Fantastic morning spent on @The_BNPA's new course on neuropsychology for physicians, led by the brilliant @vaughanbell! Basic science to clinical applications, including requesting and interpreting reports. Highly recommended!
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Important work! 👏
🧠5-HT2ARs are the most highly expressed serotonin receptor in human cortex. They are also the main target of all classical psychedelics. So what happens to 5-HT2ARs in depression? Moncrieff et al. declined to look at this in their popular umbrella review. Now we have…👇
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Great summary of our session at #WCP25
Catatonia - Where Psychiatry and Neurology meet - Session on Catatonia with Rogers, Northoff, Hrjak and Wilson. 🚨1/2 #WCP25 #WCP2025 Some key messages and thoughts 👇 - Catatonia is a complex neuropsychiatric disorder with motor, affective and cognitive-behavioural
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Autism that manifests in early childhood is distinct from autism diagnosed later in development https://t.co/aHHmPC3Mr8
nature.com
Nature - Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
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Here's an idea I've been thinking about for years: is the dopaminergic deficit in Parkinson's disease common to other conditions with psychomotor slowing? However, it took 3 students on their summer project to collect the evidence for @Brain1878. https://t.co/FIDI5dSdvL đź§µ...
academic.oup.com
Leong et al. propose that psychomotor retardation in disorders such as Parkinson’s disease, catatonia, and depression may share a common mechanism—reduced
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